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2017 1
2020 2
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The how and why of identifying the hair cell mechano-electrical transduction channel.
Effertz T, Scharr AL, Ricci AJ. Effertz T, et al. Pflugers Arch. 2015 Jan;467(1):73-84. doi: 10.1007/s00424-014-1606-z. Epub 2014 Sep 23. Pflugers Arch. 2015. PMID: 25241775 Free PMC article. Review.
To this day, the molecular identity of this channel remains controversial. However, many of the hcMET channel's properties have been characterized, including pore properties, calcium-dependent ion permeability, rectification, and single channel conductance. ...
To this day, the molecular identity of this channel remains controversial. However, many of the hcMET channel's properties have been …
Antennal hearing in insects--new findings, new questions.
Nadrowski B, Effertz T, Senthilan PR, Göpfert MC. Nadrowski B, et al. Among authors: effertz t. Hear Res. 2011 Mar;273(1-2):7-13. doi: 10.1016/j.heares.2010.03.092. Epub 2010 Apr 27. Hear Res. 2011. PMID: 20430076 Review.
Mosquitoes, certain Drosophila species, and honey bees use Johnston's organ in their antennae to detect the wing-beat sounds of conspecifics. ...
Mosquitoes, certain Drosophila species, and honey bees use Johnston's organ in their antennae to detect the wing-beat sounds of consp …
Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation.
Effertz T, Becker L, Peng AW, Ricci AJ. Effertz T, et al. J Neurosci. 2017 Nov 29;37(48):11632-11646. doi: 10.1523/JNEUROSCI.1351-17.2017. Epub 2017 Oct 24. J Neurosci. 2017. PMID: 29066559 Free PMC article.
These additional data attribute PIP(2) effects to actions on MET-channel properties and not motor interactions. Further findings support PIP(2)'s role in modulating a fast, myosin-independent, and Ca(2+)-independent adaptation process, validating fast adaptation's b …
These additional data attribute PIP(2) effects to actions on MET-channel properties and not motor interactions. Further findings support PIP …
Designer aminoglycosides prevent cochlear hair cell loss and hearing loss.
Huth ME, Han KH, Sotoudeh K, Hsieh YJ, Effertz T, Vu AA, Verhoeven S, Hsieh MH, Greenhouse R, Cheng AG, Ricci AJ. Huth ME, et al. Among authors: effertz t. J Clin Invest. 2015 Feb;125(2):583-92. doi: 10.1172/JCI77424. Epub 2015 Jan 2. J Clin Invest. 2015. PMID: 25555219 Free PMC article.
Both N1MS and sisomicin suppressed growth of E. coli and K. pneumoniae, with N1MS exhibiting superior activity against extended spectrum beta lactamase producers, despite diminished activity against P. aeruginosa and S. aureus. Moreover, systemic sisomicin treatment of mic …
Both N1MS and sisomicin suppressed growth of E. coli and K. pneumoniae, with N1MS exhibiting superior activity against extended spectrum bet …
Nitinol in Passive Ossicular Reconstruction-First Results From Temporal Bone Experiments.
Bevis N, Schwarz D, Pazen D, Effertz T, Beutner D. Bevis N, et al. Among authors: effertz t. Otol Neurotol. 2020 Aug;41(7):e854-e859. doi: 10.1097/MAO.0000000000002700. Otol Neurotol. 2020. PMID: 32558758
Evaluation of artifacts of cochlear implant electrodes in cone beam computed tomography.
Bevis N, Effertz T, Beutner D, Gueldner C. Bevis N, et al. Among authors: effertz t. Eur Arch Otorhinolaryngol. 2020 Jul 15. doi: 10.1007/s00405-020-06198-y. Online ahead of print. Eur Arch Otorhinolaryngol. 2020. PMID: 32671538
Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry.
Peng AW, Effertz T, Ricci AJ. Peng AW, et al. Among authors: effertz t. Neuron. 2013 Nov 20;80(4):960-72. doi: 10.1016/j.neuron.2013.08.025. Neuron. 2013. PMID: 24267652 Free PMC article.
Using Drosophila for studying fundamental processes in hearing.
Lu Q, Senthilan PR, Effertz T, Nadrowski B, Göpfert MC. Lu Q, et al. Among authors: effertz t. Integr Comp Biol. 2009 Dec;49(6):674-80. doi: 10.1093/icb/icp072. Epub 2009 Jul 28. Integr Comp Biol. 2009. PMID: 21665849
Insects have neither a cochlea nor hair cells, yet recent studies demonstrate that an active process that is equivalent to the cochlear amplifier occurs in at least some insect ears; like hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila actively gene …
Insects have neither a cochlea nor hair cells, yet recent studies demonstrate that an active process that is equivalent to the cochlear ampl …
Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.
Effertz T, Nadrowski B, Piepenbrock D, Albert JT, Göpfert MC. Effertz T, et al. Nat Neurosci. 2012 Sep;15(9):1198-200. doi: 10.1038/nn.3175. Epub 2012 Jul 29. Nat Neurosci. 2012. PMID: 22842145
Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring....
Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or …
The neural basis of Drosophila gravity-sensing and hearing.
Kamikouchi A, Inagaki HK, Effertz T, Hendrich O, Fiala A, Göpfert MC, Ito K. Kamikouchi A, et al. Among authors: effertz t. Nature. 2009 Mar 12;458(7235):165-71. doi: 10.1038/nature07810. Nature. 2009. PMID: 19279630
We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which houses specialized clusters of mechanosensory neurons, each of which monitors specific movements of the antenna. ...
We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which houses specialized cluster …
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