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Efficacy and safety of a third-generation oncolytic herpes virus G47delta in models of human esophageal carcinoma.
Yajima S, Sugawara K, Iwai M, Tanaka M, Seto Y, Todo T. Yajima S, et al. Mol Ther Oncolytics. 2021 Oct 30;23:402-411. doi: 10.1016/j.omto.2021.10.012. eCollection 2021 Dec 17. Mol Ther Oncolytics. 2021. PMID: 34853811 Free PMC article.
Treatment options are limited for esophageal carcinoma (EC). G47delta, a triple-mutated, conditionally replicating herpes simplex virus type 1 (HSV-1), exhibits enhanced killing of tumor cells with high safety features. ...To mimic the clinical treatment situations, …
Treatment options are limited for esophageal carcinoma (EC). G47delta, a triple-mutated, conditionally replicating herpes simp …
Role of Immunotherapy in Advanced Gastroesophageal Cancer.
Terrero G, Lockhart AC. Terrero G, et al. Curr Oncol Rep. 2020 Aug 17;22(11):112. doi: 10.1007/s11912-020-00975-y. Curr Oncol Rep. 2020. PMID: 32803457 Review.
Here, we will review the role of immunotherapy in advanced gastroesophageal cancers including targeted antibodies, immunomodulating agents, vaccines, oncolytic virus therapy, and adoptive immunotherapy, and discuss the future direction for immunotherapy in this popu …
Here, we will review the role of immunotherapy in advanced gastroesophageal cancers including targeted antibodies, immunomodulating agents, …
HSV: The scout and assault for digestive system tumors.
Li S, Li Q, Ren Y, Yi J, Guo J, Kong X. Li S, et al. Front Mol Biosci. 2023 Feb 28;10:1142498. doi: 10.3389/fmolb.2023.1142498. eCollection 2023. Front Mol Biosci. 2023. PMID: 36926680 Free PMC article. Review.
More than 25% of all malignant tumors are digestive system tumors (DSTs), which mostly include esophageal cancer, gastric cancer, pancreatic cancer, liver cancer, gallbladder cancer and cholangiocarcinoma, and colorectal cancer. ...A type of immunotherapy known as …
More than 25% of all malignant tumors are digestive system tumors (DSTs), which mostly include esophageal cancer, gastric canc …
Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery.
Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, Fujiwara T. Kuroda S, et al. Cancer Res. 2010 Nov 15;70(22):9339-48. doi: 10.1158/0008-5472.CAN-10-2333. Epub 2010 Nov 2. Cancer Res. 2010. PMID: 21045143
As a variety of viral products interact with the DNA repair machinery, oncolytic virotherapy may improve the therapeutic window of conventional radiotherapy. Here, we describe the mechanistic basis for synergy of irradiation and OBP-301 (Telomelysin), an attenuated type-5 …
As a variety of viral products interact with the DNA repair machinery, oncolytic virotherapy may improve the therapeutic window of conventio …
Anti-tumor effects of an oncolytic adenovirus expressing hemagglutinin-neuraminidase of Newcastle disease virus in vitro and in vivo.
He D, Sun L, Li C, Hu N, Sheng Y, Chen Z, Li X, Chi B, Jin N. He D, et al. Viruses. 2014 Feb 18;6(2):856-74. doi: 10.3390/v6020856. Viruses. 2014. PMID: 24553109 Free PMC article.
Here, we assessed the ability of a novel dual-specific anti-tumor oncolytic adenovirus, expressing the hemagglutinin-neuraminidase (HN) gene from the Newcastle disease virus under the human telomerase reverse transcriptase (hTERT) promoter (Ad-hTERTp-E1a-HN), to inh …
Here, we assessed the ability of a novel dual-specific anti-tumor oncolytic adenovirus, expressing the hemagglutinin-neuramini …