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2017 1
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Page 1
Corticosteroid-resistant immune-related adverse events: a systematic review.
Daetwyler E, Wallrabenstein T, König D, Cappelli LC, Naidoo J, Zippelius A, Läubli H. Daetwyler E, et al. J Immunother Cancer. 2024 Jan 17;12(1):e007409. doi: 10.1136/jitc-2023-007409. J Immunother Cancer. 2024. PMID: 38233099 Free PMC article.
Immune checkpoint inhibitor (ICI) treatment has become an important therapeutic option for various cancer types. ...Most publications investigated sr colitis (n=26), followed by hepatitis (n=21), pneumonitis (n=17) and myocarditis (n=15). There …
Immune checkpoint inhibitor (ICI) treatment has become an important therapeutic option for various cancer types. …
Steroid-refractory immune checkpoint inhibitor (ICI) hepatitis and ICI rechallenge: A systematic review and meta-analysis.
Hwang SY, Hsieh P, Zhang W. Hwang SY, et al. Hepatol Commun. 2024 Sep 18;8(10):e0525. doi: 10.1097/HC9.0000000000000525. eCollection 2024 Oct 1. Hepatol Commun. 2024. PMID: 39298568 Free PMC article.
However, this has also resulted in the emergence of immune-related adverse events, notably ICI hepatitis, posing a significant clinical challenge. While steroids are the primary treatment, there are increasing cases of steroid-refractory ICI hepatit …
However, this has also resulted in the emergence of immune-related adverse events, notably ICI hepatitis, posing a significant …
Checkpoint inhibitor-induced hepatotoxicity: Role of liver biopsy and management approach.
Bessone F, Bjornsson ES. Bessone F, et al. World J Hepatol. 2022 Jul 27;14(7):1269-1276. doi: 10.4254/wjh.v14.i7.1269. World J Hepatol. 2022. PMID: 36158917 Free PMC article.
Liver injury has been reported in 3%-8% of patients with grade III-IV hepatitis in retrospective studies. The liver injury is characterized by hepatocellular injury resembling autoimmune hepatitis biochemically but not immunologically as patients with ICI ind …
Liver injury has been reported in 3%-8% of patients with grade III-IV hepatitis in retrospective studies. The liver injury is charact …
How should immune checkpoint inhibitor myocarditis be treated?
Badaan S, Abbass A, Tov S, Bar-Sela G, Bisharat N. Badaan S, et al. Cardiooncology. 2025 Nov 17;11(1):108. doi: 10.1186/s40959-025-00404-8. Cardiooncology. 2025. PMID: 41250193 Free PMC article. Review.
However, these therapies can disrupt immune self-tolerance, leading to immune-related adverse events, among which immune checkpoint inhibitor-related myocarditis (ICIrM) is associated with the highest mortality rates. ...For confirmed ICIrM, corticosteroids r …
However, these therapies can disrupt immune self-tolerance, leading to immune-related adverse events, among which immune checkpoin …
Immunosuppressant mycophenolate mofetil for patients with steroid-refractory immune-related hepatitis induced by checkpoint inhibitors in oncology.
Alouani E, Laparra A, Perret A, Sakkal M, Messayke S, Danlos FX, Ouali K, Hollebecque A, Even C, Ammari S, Baldini C, Champiat S, Besse B, Robert C, Guettier C, Samuel D, Lambotte O, De Martin E, Michot JM. Alouani E, et al. Eur J Cancer. 2023 Nov;193:113313. doi: 10.1016/j.ejca.2023.113313. Epub 2023 Aug 26. Eur J Cancer. 2023. PMID: 37748398
BACKGROUND: Immune-checkpoint inhibitor (ICI) hepatitis, which does not improve with steroids and requires additional immunosuppressant, is defined as steroid-refractory ICI hepatitis. ...Mycophenolate mofetil …
BACKGROUND: Immune-checkpoint inhibitor (ICI) hepatitis, which does not improve with steroids and require …
Therapeutic agents for steroid-refractory immune checkpoint inhibitor-related myocarditis: a narrative review.
Wang Y, Li S, Shi H, Guan X, Wei Q, Chen D. Wang Y, et al. Cardiovasc Diagn Ther. 2024 Aug 31;14(4):679-697. doi: 10.21037/cdt-24-114. Epub 2024 Aug 12. Cardiovasc Diagn Ther. 2024. PMID: 39263485 Free PMC article. Review.
BACKGROUND AND OBJECTIVE: Immune checkpoint inhibitors (ICIs) have become one of the cornerstones of current oncology treatment, and immune checkpoint inhibitor-related myocarditis (IRM) is the most fatal of all immune checkpoint inhibitor …
BACKGROUND AND OBJECTIVE: Immune checkpoint inhibitors (ICIs) have become one of the cornerstones of current oncology treatment, and immu …
Immune Checkpoint Inhibitor-Associated Myocarditis: Risk, Diagnosis, and Clinical Impact.
Mauriello A, Correra A, Maratea AC, Cetoretta V, Benfari G, Ilardi F, Cocchia R, Lisi M, Malagoli A, Mandoli GE, Pastore MC, Sperlongano S, Russo V, Cameli M, D'Andrea A; Working Group of Echocardiography of the Italian Society of Cardiology. Mauriello A, et al. J Clin Med. 2026 Jan 19;15(2):814. doi: 10.3390/jcm15020814. J Clin Med. 2026. PMID: 41598751 Free PMC article. Review.
Diagnosis relies on a multimodal approach. Management requires immediate ICI cessation and initiation of high-dose corticosteroids as first-line therapy. For steroid-refractory cases, second-line options include mycophenolate mofetil (MMF), intr …
Diagnosis relies on a multimodal approach. Management requires immediate ICI cessation and initiation of high-dose corticosteroids as …
Advances in mechanistic investigation and treatment of steroid-refractory ICI-induced liver injury.
Hu H, Shen X, Chen J. Hu H, et al. Clin Exp Med. 2025 Aug 11;25(1):288. doi: 10.1007/s10238-025-01721-z. Clin Exp Med. 2025. PMID: 40788551 Free PMC article. Review.
However, their use is frequently associated with immune-related adverse events, including immune checkpoint inhibitor-induced liver injury (ICI-DILI), which poses substantial clinical challenges. While corticosteroid therapy remains the primary …
However, their use is frequently associated with immune-related adverse events, including immune checkpoint inhibitor-i …
Steroid-Refractory Immune-Related Adverse Events Induced by Checkpoint Inhibitors.
Tomsitz D, Ruf T, Zierold S, French LE, Heinzerling L. Tomsitz D, et al. Cancers (Basel). 2023 Apr 28;15(9):2538. doi: 10.3390/cancers15092538. Cancers (Basel). 2023. PMID: 37174003 Free PMC article.
Sr-irAEs and sd-irAEs (n = 25) were detected in 10.9% of all irAEs, and in 6.2% of ICI-treated patients. In this cohort, infliximab (48%) and mycophenolate mofetil (28%) were most often administered as second-line immunosuppressants. ...Although these side ef …
Sr-irAEs and sd-irAEs (n = 25) were detected in 10.9% of all irAEs, and in 6.2% of ICI-treated patients. In this cohort, infliximab ( …
Diagnosis and management of immune mediated liver injury from checkpoint inhibitors.
Likhitsup A, Fontana RJ. Likhitsup A, et al. Curr Opin Gastroenterol. 2024 May 1;40(3):164-171. doi: 10.1097/MOG.0000000000001015. Epub 2024 Feb 15. Curr Opin Gastroenterol. 2024. PMID: 38375823 Review.
In contrast, the 2-3% with grade 3/4 hepatotoxicity frequently require oral or intravenous corticosteroids and some are hospitalized to initiate further immunosuppression with mycophenolate mofetil or azathioprine. Liver biopsy is generally reserved for patients wit …
In contrast, the 2-3% with grade 3/4 hepatotoxicity frequently require oral or intravenous corticosteroids and some are hospitalized to init …
68 results