Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2015 2
2018 2
2019 3
2020 1
2021 2
2022 1
2023 1
2025 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

13 results

Results by year

Filters applied: . Clear all
Page 1
The Role of Checkpoint Inhibitors in Glioblastoma.
Desai K, Hubben A, Ahluwalia M. Desai K, et al. Target Oncol. 2019 Aug;14(4):375-394. doi: 10.1007/s11523-019-00655-3. Target Oncol. 2019. PMID: 31290002 Review.
Given its poor prognosis, glioblastoma represents an area of high unmet clinical need. Standard of care for the treatment of glioblastoma in the frontline setting is limited to surgical resection, radiation, and temozolomide, with the more recent addition of Tumor T …
Given its poor prognosis, glioblastoma represents an area of high unmet clinical need. Standard of care for the treatment of gliob …
Efficacy of Oncolytic Virus VV-GMCSF-Lact Against Immunocompetent Glioma.
Ageenko A, Vasileva N, Yusubalieva G, Sen'kova A, Romashchenko A, Gubskiy I, Zabozlaev F, Zavyalov E, Dymova M, Richter V, Kuligina E. Ageenko A, et al. Cells. 2025 Oct 17;14(20):1619. doi: 10.3390/cells14201619. Cells. 2025. PMID: 41148834 Free PMC article.
Virotherapy is a promising method for treating oncological diseases, including such aggressive and difficult-to-treat brain tumors such as glioblastoma. Recombinant vaccinia virus VV-GMCSF-Lact has previously shown high antitumor potential against tumor cells of varying hi …
Virotherapy is a promising method for treating oncological diseases, including such aggressive and difficult-to-treat brain tumors such as …
Therapeutic Application of Brain-Specific Angiogenesis Inhibitor 1 for Cancer Therapy.
Nair M, Bolyard C, Lee TJ, Kaur B, Yoo JY. Nair M, et al. Cancers (Basel). 2021 Jul 16;13(14):3562. doi: 10.3390/cancers13143562. Cancers (Basel). 2021. PMID: 34298774 Free PMC article. Review.
Additionally, its expression is reduced in brain cancers, such as glioblastoma (GBM) and peripheral cancers, suggesting that BAI1 is a tumor suppressor gene. ...Its expression has also been shown to be inversely correlated with tumor progression, neovascularization, and pe …
Additionally, its expression is reduced in brain cancers, such as glioblastoma (GBM) and peripheral cancers, suggesting that BAI1 is …
EXPLORING THE ANTITUMOR EFFECT OF VIRUS IN MALIGNANT GLIOMA.
Saha D, Ahmed SS, Rabkin SD. Saha D, et al. Drugs Future. 2015;40(11):739-749. doi: 10.1358/dof.2015.040.11.2383070. Drugs Future. 2015. PMID: 26855472 Free PMC article.
OVs have been used in numerous preclinical studies in malignant glioma, and a large number of clinical trials using OVs have been completed or are underway that have demonstrated safety, as well as provided indications of effective antiglioma activity. In this revie …
OVs have been used in numerous preclinical studies in malignant glioma, and a large number of clinical trials using OVs have b …
Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models.
Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar E, Aguilar LK, Guzik BW, Barone F, Tak PP, Tabatabai G, Lederer JA, Chiocca EA, Lawler S. Koch MS, et al. J Immunother Cancer. 2022 Jan;10(1):e003368. doi: 10.1136/jitc-2021-003368. J Immunother Cancer. 2022. PMID: 35017150 Free PMC article.
CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine kinase to cancer cells, resulting in local conversion of ganciclovir or valacyclovir into a toxic metabolite. ...CAN-2409 treatment has shown promising results in clin …
CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine kinase to cancer cells, res …
Glioblastoma treatment slowly moves toward change: novel druggable targets and translational horizons in 2022.
Gatto L, Franceschi E, Tosoni A, Di Nunno V, Bartolini S, Brandes AA. Gatto L, et al. Expert Opin Drug Discov. 2023 Mar;18(3):269-286. doi: 10.1080/17460441.2023.2174097. Epub 2023 Feb 16. Expert Opin Drug Discov. 2023. PMID: 36718723
INTRODUCTION: Glioblastoma (GBM) is the most common primary brain tumor in adults. GBM treatment options have been the same for the past 30 years and have only modestly extended survival, despite aggressive multimodal treatments. ...Nevertheless, stimulating insights for f …
INTRODUCTION: Glioblastoma (GBM) is the most common primary brain tumor in adults. GBM treatment options have been the same for the p …
Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways.
Tomita Y, Kurozumi K, Yoo JY, Fujii K, Ichikawa T, Matsumoto Y, Uneda A, Hattori Y, Shimizu T, Otani Y, Oka T, Kaur B, Date I. Tomita Y, et al. Mol Cancer Ther. 2019 Aug;18(8):1418-1429. doi: 10.1158/1535-7163.MCT-18-0799. Epub 2019 May 15. Mol Cancer Ther. 2019. PMID: 31092561
Anti-VEGF treatments such as bevacizumab have demonstrated convincing therapeutic advantage in patients with glioblastoma. However, bevacizumab has also been reported to induce invasiveness of glioma. In this study, we examined the effects of ra …
Anti-VEGF treatments such as bevacizumab have demonstrated convincing therapeutic advantage in patients with gliobla …
A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE).
Cloughesy TF, Brenner A, de Groot JF, Butowski NA, Zach L, Campian JL, Ellingson BM, Freedman LS, Cohen YC, Lowenton-Spier N, Rachmilewitz Minei T, Fain Shmueli S; GLOBE Study Investigators; Wen PY. Cloughesy TF, et al. Neuro Oncol. 2020 May 15;22(5):705-717. doi: 10.1093/neuonc/noz232. Neuro Oncol. 2020. PMID: 31844890 Free PMC article. Clinical Trial.
BACKGROUND: Ofranergene obadenovec (VB-111) is an anticancer viral therapy that demonstrated in a phase II study a survival benefit for patients with recurrent glioblastoma (rGBM) who were primed with VB-111 monotherapy that was continued after progression wi …
BACKGROUND: Ofranergene obadenovec (VB-111) is an anticancer viral therapy that demonstrated in a phase II study a survival be …
Validation of diffusion MRI as a biomarker for efficacy using randomized phase III trial of bevacizumab with or without VB-111 in recurrent glioblastoma.
Ellingson BM, Patel K, Wang C, Raymond C, Brenner A, de Groot JF, Butowski NA, Zach L, Campian JL, Schlossman J, Rizvi S, Cohen YC, Lowenton-Spier N, Minei TR, Shmueli SF, Wen PY, Cloughesy TF. Ellingson BM, et al. Neurooncol Adv. 2021 Jun 19;3(1):vdab082. doi: 10.1093/noajnl/vdab082. eCollection 2021 Jan-Dec. Neurooncol Adv. 2021. PMID: 34377989 Free PMC article.
BACKGROUND: Evidence from single and multicenter phase II trials have suggested diffusion MRI is a predictive imaging biomarker for survival benefit in recurrent glioblastoma (rGBM) treated with anti-VEGF therapy. The current study confirms these findings in …
BACKGROUND: Evidence from single and multicenter phase II trials have suggested diffusion MRI is a predictive imaging biomarker for survival …
Suppression of HMGB1 Released in the Glioblastoma Tumor Microenvironment Reduces Tumoral Edema.
Hong B, Muili K, Bolyard C, Russell L, Lee TJ, Banasavadi-Siddegowda Y, Yoo JY, Yan Y, Ballester LY, Bockhorst KH, Kaur B. Hong B, et al. Mol Ther Oncolytics. 2018 Dec 6;12:93-102. doi: 10.1016/j.omto.2018.11.005. eCollection 2019 Mar 29. Mol Ther Oncolytics. 2018. PMID: 30719499 Free PMC article.
The impact of secreted HMGB1 on tumor growth and response to oncolytic viral therapy was evaluated by using HMGB1-blocking antibodies in vitro and in mice bearing intracranial tumors. IVIS and MRI imaging was utilized to visualize in real time virus spread, tumor gr …
The impact of secreted HMGB1 on tumor growth and response to oncolytic viral therapy was evaluated by using HMGB1-blocking ant …
13 results