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Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Chen Q, et al. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31. Science. 2016. PMID: 26721680 Free article.
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. ...Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced met …
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains uncl …
Sperm RNA code programmes the metabolic health of offspring.
Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q. Zhang Y, et al. Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Nat Rev Endocrinol. 2019. PMID: 31235802 Free PMC article. Review.
Mammalian sperm RNA is increasingly recognized as an additional source of paternal hereditary information beyond DNA. Environmental inputs, including an unhealthy diet, mental stresses and toxin exposure, can reshape the sperm RNA signature and induce offspring phen …
Mammalian sperm RNA is increasingly recognized as an additional source of paternal hereditary information beyond DNA. Environmental i …
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Zhang Y, et al. Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25. Nat Cell Biol. 2018. PMID: 29695786 Free PMC article.
The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA (1) . ...Also, Dnmt2 deletion altered the sperm
The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may functi …
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications.
Chen Q, Yan W, Duan E. Chen Q, et al. Nat Rev Genet. 2016 Dec;17(12):733-743. doi: 10.1038/nrg.2016.106. Epub 2016 Oct 3. Nat Rev Genet. 2016. PMID: 27694809 Free PMC article. Review.
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, and their roles …
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recentl …
Atg7 is required for acrosome biogenesis during spermatogenesis in mice.
Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, Yang L, Tang H, Zhang X, Duan E, Zhao X, Gao F, Li W. Wang H, et al. Cell Res. 2014 Jul;24(7):852-69. doi: 10.1038/cr.2014.70. Epub 2014 May 23. Cell Res. 2014. PMID: 24853953 Free PMC article.
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. ...Furthermore, the depletion of Atg7 in germ cells did not affect the early stages of development of germ cells, but at …
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process …
Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration.
Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E. Chen Q, et al. Cell Res. 2011 Jun;21(6):922-33. doi: 10.1038/cr.2010.169. Epub 2010 Dec 7. Cell Res. 2011. PMID: 21135872 Free PMC article.
The sperm defect is a result of impaired sperm volume regulation and progressive cell swelling in response to physiological hypotonic stress during male-female reproductive tract transition. ...The tail deformation hampered sperm migration into oviduct, resul …
The sperm defect is a result of impaired sperm volume regulation and progressive cell swelling in response to physiological hy …
Aquaporins in sperm osmoadaptation: an emerging role for volume regulation.
Chen Q, Duan EK. Chen Q, et al. Acta Pharmacol Sin. 2011 Jun;32(6):721-4. doi: 10.1038/aps.2011.35. Epub 2011 May 9. Acta Pharmacol Sin. 2011. PMID: 21552294 Free PMC article.
This hypo-osmotic exposure not only activates sperm motility, but also poses potential harm to sperm structure and function by inducing unwanted cell swelling. ...Aquaporins have been implicated in sperm osmoregulation. Recent discoveries show that Aquaporin- …
This hypo-osmotic exposure not only activates sperm motility, but also poses potential harm to sperm structure and function by …
Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice.
Huang L, Meng TG, Ma XS, Wang ZB, Qi ST, Chen Q, Zhang QH, Liang QX, Wang ZW, Hu MW, Guo L, Ouyang YC, Hou Y, Zhao Y, Sun QY. Huang L, et al. Cell Death Differ. 2019 May;26(5):969-980. doi: 10.1038/s41418-018-0181-9. Epub 2018 Aug 28. Cell Death Differ. 2019. PMID: 30154445 Free PMC article.
Human sperm RNA code senses dietary sugar.
Zhang Y, Chen Q. Zhang Y, et al. Nat Rev Endocrinol. 2020 Apr;16(4):200-201. doi: 10.1038/s41574-020-0331-2. Nat Rev Endocrinol. 2020. PMID: 32066893 Free article.
A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are associated with changes in sperm motility. This rapid response by sperm to nutritional fluctuation raises intriguing questions reg …
A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are asso …
A Twist between ROS and Sperm-Mediated Intergenerational Epigenetic Inheritance.
Zhang X, Chen Q. Zhang X, et al. Mol Cell. 2020 May 7;78(3):371-373. doi: 10.1016/j.molcel.2020.04.003. Mol Cell. 2020. PMID: 32386538
These changes are maintained in spermatozoa, regulating tsRNA biogenesis, and together transmit intergenerational effects....
These changes are maintained in spermatozoa, regulating tsRNA biogenesis, and together transmit intergenerational effects....
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