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Year Number of Results
1989 1
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822 results

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Page 1
Aminoglycoside-Induced Cochleotoxicity: A Review.
Jiang M, Karasawa T, Steyger PS. Jiang M, et al. Among authors: steyger ps, karasawa t. Front Cell Neurosci. 2017 Oct 9;11:308. doi: 10.3389/fncel.2017.00308. eCollection 2017. Front Cell Neurosci. 2017. PMID: 29062271 Free PMC article. Review.
Serious bacterial infections (requiring life-saving aminoglycoside treatment) induce systemic inflammatory responses that also potentiate the degree of ototoxicity and permanent hearing loss. We discuss prospective clinical strategies to protect auditory and vestibu …
Serious bacterial infections (requiring life-saving aminoglycoside treatment) induce systemic inflammatory responses that also potentiate th …
Preventing hearing loss and restoring hearing: a new outlook.
Vlajkovic SM, Thorne PR, Rajan R, Gale JE. Vlajkovic SM, et al. Among authors: gale je. Biomed Res Int. 2015;2015:868716. doi: 10.1155/2015/868716. Epub 2015 Mar 25. Biomed Res Int. 2015. PMID: 25883979 Free PMC article. No abstract available.
Preferential Cochleotoxicity of Cisplatin.
Prayuenyong P, Baguley DM, Kros CJ, Steyger PS. Prayuenyong P, et al. Among authors: steyger ps. Front Neurosci. 2021 Jul 26;15:695268. doi: 10.3389/fnins.2021.695268. eCollection 2021. Front Neurosci. 2021. PMID: 34381329 Free PMC article. Review.
Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has been consistently reported in the current literature. ...The endocochlear potential, gene …
Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial ve …
Dual-AAV vector-mediated expression of MYO7A improves vestibular function in a mouse model of Usher syndrome 1B.
Lau SC, Grati M, Isgrig K, Sinan M, Calabro KR, Zhu J, Ishibashi Y, Ozgur Z, Wafa T, Belyantseva IA, Fitzgerald T, Friedman TB, Boye SL, Boye SE, Chien WW. Lau SC, et al. Among authors: sinan m. Mol Ther Methods Clin Dev. 2023 Aug 21;30:534-545. doi: 10.1016/j.omtm.2023.08.012. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37693946 Free PMC article.
The shaker-1 mouse has a nonsense mutation in Myo7a, is profoundly deaf throughout life, and has significant vestibular dysfunction. Because of the 6.7-kb size of the MYO7A cDNA, a dual-AAV approach was used for gene delivery, which involves splitting human MYO7A cDNA int …
The shaker-1 mouse has a nonsense mutation in Myo7a, is profoundly deaf throughout life, and has significant vestibular dysfunction. …
Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents.
Lysakowski A, Govindaraju AC, Raphael RM. Lysakowski A, et al. Among authors: raphael rm. Hear Res. 2022 Dec;426:108612. doi: 10.1016/j.heares.2022.108612. Epub 2022 Sep 20. Hear Res. 2022. PMID: 36223702 Free PMC article. Review.
In heart and liver cells, mitochondria occupy over 20% of the cellular volume and the major need for ATP is easily identifiable - i.e., to drive cross-bridge recycling in cardiac cells or biosynthetic machinery in liver cells. In vestibular and cochlear hair cells the over …
In heart and liver cells, mitochondria occupy over 20% of the cellular volume and the major need for ATP is easily identifiable - i.e., to d …
Monitoring neonates for ototoxicity.
Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS. Garinis AC, et al. Among authors: steyger ps. Int J Audiol. 2018 Sep;57(sup4):S41-S48. doi: 10.1080/14992027.2017.1339130. Epub 2017 Jun 22. Int J Audiol. 2018. PMID: 28949262 Free PMC article. Review.
OBJECTIVES: Neonates admitted to the neonatal intensive care unit (NICU) are at greater risk of permanent hearing loss compared to infants in well mother and baby units. Several factors have been associated with this increased prevalence of hearing loss, including c …
OBJECTIVES: Neonates admitted to the neonatal intensive care unit (NICU) are at greater risk of permanent hearing loss compared to in …
Editorial: Cellular Mechanisms of Ototoxicity.
Steyger PS, Cunningham LL, Esquivel CR, Watts KL, Zuo J. Steyger PS, et al. Front Cell Neurosci. 2018 Mar 27;12:75. doi: 10.3389/fncel.2018.00075. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29636663 Free PMC article. No abstract available.
Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity.
Steyger PS. Steyger PS. Am J Audiol. 2021 Oct 11;30(3S):887-900. doi: 10.1044/2021_AJA-21-00006. Epub 2021 Aug 20. Am J Audiol. 2021. PMID: 34415784 Free PMC article. Review.
Hearing loss has long-term impacts on quality-of-life measures, especially in young children and older adults. This review article also highlights some of the current knowledge gaps regarding iatrogenic causes of hearing loss. Conclusion Further research is urgently
Hearing loss has long-term impacts on quality-of-life measures, especially in young children and older adults. This review article al
Animal Models of Hearing Loss after Cochlear Implantation and Electrical Stimulation.
Reiss LAJ, Kirk J, Claussen AD, Fallon JB. Reiss LAJ, et al. Hear Res. 2022 Dec;426:108624. doi: 10.1016/j.heares.2022.108624. Epub 2022 Sep 29. Hear Res. 2022. PMID: 36207191 Review.
Many hearing-impaired patients may significantly benefit from the Hybrid or electro-acoustic stimulation (EAS) cochlear implant (CI). ...Here we review the parameters required for rigorous study of mechanisms of post-implantation hearing loss, including selec …
Many hearing-impaired patients may significantly benefit from the Hybrid or electro-acoustic stimulation (EAS) cochlear implan …
822 results