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Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate-to-severe atopic dermatitis.
Hartmann J, Moitinho-Silva L, Sander N, Harder I, Häsler R, Rodriguez E, Haufe E, Kleinheinz A, Abraham S, Heratizadeh A, Weisshaar E, Schäkel K, Handrick C, Augustin M, Wollenberg A, Staubach-Renz P, Ertner K, Sticherling M, Schwarz B, Quist S, Wiemers F, Schenck F, Wildberger J, Tittmann L, Lieb W, Schmitt J, Werfel T, Weidinger S; TREATgermany Study Group. Hartmann J, et al. Allergy. 2023 Apr 9. doi: 10.1111/all.15742. Online ahead of print. Allergy. 2023. PMID: 37032440
We aimed to investigate associations among AD patients' skin microbiome, clinical data, and response to systemic therapy in patients of the TREATgermany registry. METHODS: Skin swabs of 157 patients were profiled with 16S rRNA gene amplicon sequencing before and aft …
We aimed to investigate associations among AD patients' skin microbiome, clinical data, and response to systemic therapy in patients of the …
Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany.
Weisshaar E, Bentz P, Apfelbacher C, Haufe E, Heinrich L, Heratizadeh A, Abraham S, Harder I, Kleinheinz A, Wollenberg A, Schäkel K, Wiemers F, Ertner J, Augustin M, Wildberger J, Von Kiedrowski R, Worm M, Zink A, Effendy I, Asmussen A, Pawlak M, Sticherling M, Hilgers M, Handrick C, Quist S, Schwarz B, Bell M, Staubach-Renz P, Hong-Weldemann SH, Homey B, Brücher JJ, Weidinger S, Werfel T, Schmitt J; TREATgermany study group. Weisshaar E, et al. Acta Derm Venereol. 2023 Jan 23;103:adv00854. doi: 10.2340/actadv.v103.4426. Acta Derm Venereol. 2023. PMID: 36688701 Free article.
TREATgermany is an investigator-initiated prospective disease registry. ...
TREATgermany is an investigator-initiated prospective disease registry. ...
Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry.
Stölzl D, Sander N, Heratizadeh A, Haufe E, Harder I, Abraham S, Heinrich L, Kleinheinz A, Wollenberg A, Weisshaar E, Schäkel K, Ertner K, Wiemers F, Wildberger J, Worm M, von Kiedrowski R, Effendy I, Asmussen A, Augustin M, Pawlak M, Sticherling M, Zink A, Hilgers M, Handrick C, Quist S, Schwarz B, Staubach-Renz P, Bell M, Hong-Weldemann SH, Homey B, Brücher JJ, Schmitt J, Werfel T, Weidinger S; TREATgermany study group. Stölzl D, et al. Br J Dermatol. 2022 Dec;187(6):1022-1024. doi: 10.1111/bjd.21794. Epub 2022 Sep 6. Br J Dermatol. 2022. PMID: 35895855
This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions....
This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and …
Blood transcriptome profiling identifies 2 candidate endotypes of atopic dermatitis.
Möbus L, Rodriguez E, Harder I, Boraczynski N, Szymczak S, Hübenthal M, Stölzl D, Gerdes S, Kleinheinz A, Abraham S, Heratizadeh A, Handrick C, Haufe E, Werfel T, Schmitt J, Weidinger S; Biomap and the TREATgermany study group. Möbus L, et al. J Allergy Clin Immunol. 2022 Aug;150(2):385-395. doi: 10.1016/j.jaci.2022.02.001. Epub 2022 Feb 16. J Allergy Clin Immunol. 2022. PMID: 35182548 Free article.
METHODS: Blood messenger RNA sequencing on 60 adults from the TREATgermany registry including 49 patients before and after dupilumab treatment, as well as from an independent cohort of 31 patients and 43 controls was performed. ...
METHODS: Blood messenger RNA sequencing on 60 adults from the TREATgermany registry including 49 patients before and after dup …
Atopic dermatitis and depressive symptoms. Results of the German national AD Registry TREATgermany.
Helmert C, Haufe E, Heinrich L, Siegels D, Abraham S, Heratizadeh A, Harder I, Kleinheinz A, Wollenberg A, Wiemers F, Weisshaar E, Augustin M, von Kiedrowski R, Zink A, Pawlak M, Schäkel K, Wildberger J, Weidinger S, Werfel T, Schmitt J; TREATgermany Study Group. Helmert C, et al. J Eur Acad Dermatol Venereol. 2022 Apr;36(4):e279-e282. doi: 10.1111/jdv.17812. Epub 2021 Dec 7. J Eur Acad Dermatol Venereol. 2022. PMID: 34779054 No abstract available.
Atopic dermatitis: disease characteristics and comorbidities in smoking and non-smoking patients from the TREATgermany registry.
Pilz AC, Schielein MC, Schuster B, Heinrich L, Haufe E, Abraham S, Heratizadeh A, Harder I, Kleinheinz A, Wollenberg A, Wiemers F, Weisshaar E, Augustin M, von Kiedrowski R, Pawlak M, Schäkel K, Wildberger J, Hilgers M, Werfel T, Weidinger S, Schmitt J, Biedermann T, Zink A; and the TREATgermany Study Group. Pilz AC, et al. J Eur Acad Dermatol Venereol. 2022 Mar;36(3):413-421. doi: 10.1111/jdv.17789. Epub 2021 Nov 30. J Eur Acad Dermatol Venereol. 2022. PMID: 34743344
OBJECTIVES: In this study, AD characteristics and its atopic comorbidities are compared in smoking and non-smoking AD patients. METHODS: TREATgermany is a non-interventional clinical registry which includes patients with moderate to severe AD in Germany. Baseline da …
OBJECTIVES: In this study, AD characteristics and its atopic comorbidities are compared in smoking and non-smoking AD patients. METHODS: …
Wahrnehmung der Corona-Pandemie durch Neurodermitispatienten - Ergebnisse aus dem Neurodermitisregister TREATgermany.
Helmert C, Siegels D, Haufe E, Abraham S, Heratizadeh A, Kleinheinz A, Harder I, Schäkel K, Effendy I, Wollenberg A, Sticherling M, Stahl M, Worm M, Schwichtenberg U, Schwarz B, Rossbacher J, Buck PM, Schenck F, Werfel T, Weidinger S, Schmitt J; das TREATgermany Studienteam. Helmert C, et al. J Dtsch Dermatol Ges. 2022 Jan;20(1):45-58. doi: 10.1111/ddg.14655_g. J Dtsch Dermatol Ges. 2022. PMID: 35040570 German.
Perception of the coronavirus pandemic by patients with atopic dermatitis - Results from the TREATgermany registry.
Helmert C, Siegels D, Haufe E, Abraham S, Heratizadeh A, Kleinheinz A, Harder I, Schäkel K, Effendy I, Wollenberg A, Sticherling M, Stahl M, Worm M, Schwichtenberg U, Schwarz B, Rossbacher J, Buck PM, Schenck F, Werfel T, Weidinger S, Schmitt J; TREATgermany Study Team. Helmert C, et al. J Dtsch Dermatol Ges. 2022 Jan;20(1):45-57. doi: 10.1111/ddg.14655. Epub 2021 Dec 27. J Dtsch Dermatol Ges. 2022. PMID: 34958179
BACKGROUND: TREATgermany, a registry for patients with moderate to severe atopic dermatitis (AD), established an additional questionnaire in spring 2020 to investigate the effects of the coronavirus pandemic on the daily life of patients with AD. ...However, patient …
BACKGROUND: TREATgermany, a registry for patients with moderate to severe atopic dermatitis (AD), established an additional qu …
Status report on the atopic dermatitis registry TREATgermany.
Siegels D, Haufe E, Heinrich L, Werfel T, Weidinger S, Schmitt J; TREATgermany Study Group. Siegels D, et al. Allergol Select. 2021 Aug 27;5:274-286. doi: 10.5414/ALX02262E. eCollection 2021. Allergol Select. 2021. PMID: 34532636 Free PMC article. Review.
BACKGROUND: The TREATgermany registry collects data from children, adolescents, and adults with moderate-to-severe atopic dermatitis (AD) in Germany. ...The registry fulfills the methodological requirements of IQWiG for the collection and processing of health …
BACKGROUND: The TREATgermany registry collects data from children, adolescents, and adults with moderate-to-severe atopic derm …
Elevated NK-cell transcriptional signature and dysbalance of resting and activated NK cells in atopic dermatitis.
Möbus L, Rodriguez E, Harder I, Schwarz A, Wehkamp U, Stölzl D, Boraczynski N, Gerdes S, Litman T, Kleinheinz A, Abraham S, Heratizadeh A, Handrick C, Haufe E, Schmitt J, Werfel T, Weidinger S; TREATgermany Study Group. Möbus L, et al. J Allergy Clin Immunol. 2021 May;147(5):1959-1965.e2. doi: 10.1016/j.jaci.2020.11.022. Epub 2020 Dec 31. J Allergy Clin Immunol. 2021. PMID: 33390269
Atopic dermatitis displays stable and dynamic skin transcriptome signatures.
Möbus L, Rodriguez E, Harder I, Stölzl D, Boraczynski N, Gerdes S, Kleinheinz A, Abraham S, Heratizadeh A, Handrick C, Haufe E, Werfel T, Schmitt J, Weidinger S; TREATgermany study group. Möbus L, et al. J Allergy Clin Immunol. 2021 Jan;147(1):213-223. doi: 10.1016/j.jaci.2020.06.012. Epub 2020 Jun 29. J Allergy Clin Immunol. 2021. PMID: 32615169
OBJECTIVES: Our aim was to explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany registry. METHODS: Biopsy specimens from 59 patients with moderate-to-severe AD before and 30 patients 12 weeks after start of systemic tre …
OBJECTIVES: Our aim was to explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany reg …
The European TREatment of ATopic eczema (TREAT) Registry Taskforce survey: prescribing practices in Europe for phototherapy and systemic therapy in adult patients with moderate-to-severe atopic eczema.
Vermeulen FM, Gerbens LAA, Schmitt J, Deleuran M, Irvine AD, Logan K, Ouwerkerk W, Vestergaard C, Flohr C, Spuls PI; international TREAT Registry Taskforce. Vermeulen FM, et al. Br J Dermatol. 2020 Dec;183(6):1073-1082. doi: 10.1111/bjd.18959. Epub 2020 Mar 18. Br J Dermatol. 2020. PMID: 32068893 Free PMC article.
Implementation of dupilumab in routine care of atopic eczema: results from the German national registry TREATgermany.
Abraham S, Haufe E, Harder I, Heratizadeh A, Kleinheinz A, Wollenberg A, Weisshaar E, Augustin M, Wiemers F, Zink A, Biedermann T, von Kiedrowski R, Hilgers M, Worm M, Pawlak M, Sticherling M, Fell I, Handrick C, Schäkel K, Staubach P, Asmussen A, Schwarz B, Bell M, Neubert K, Effendy I, Bieber T, Homey B, Gerlach B, Tchitcherina E, Stahl M, Schwichtenberg U, Rossbacher J, Buck P, Mempel M, Beissert S, Werfel T, Weidinger S, Schmitt J; TREATgermany study group. Abraham S, et al. Br J Dermatol. 2020 Aug;183(2):382-384. doi: 10.1111/bjd.18958. Epub 2020 Apr 13. Br J Dermatol. 2020. PMID: 32068242 No abstract available.
Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany.
Heratizadeh A, Haufe E, Stölzl D, Abraham S, Heinrich L, Kleinheinz A, Wollenberg A, Weisshaar E, Augustin M, Wiemers F, Zink A, von Kiedrowski R, Hilgers M, Worm M, Pawlak M, Sticherling M, Fell I, Handrick C, Schäkel K, Staubach-Renz P, Asmussen A, Schwarz B, Bell M, Effendy I, Bieber T, Homey B, Gerlach B, Tchitcherina E, Stahl M, Schwichtenberg U, Rossbacher J, Buck P, Mempel M, Beissert S, Biedermann T, Weidinger S, Schmitt J, Werfel T; TREATgermany Study Group. Heratizadeh A, et al. J Eur Acad Dermatol Venereol. 2020 Jun;34(6):1263-1272. doi: 10.1111/jdv.16078. Epub 2020 Feb 13. J Eur Acad Dermatol Venereol. 2020. PMID: 31721316
BACKGROUND: The Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society for Dermatology (DDG) in 2011 to evaluate the 'real-life' situation of health care for patients with AD. OBJECTIVES: Interim data analysis on baseline characteristics as …
BACKGROUND: The Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society for Dermatology (DDG) in 2011 …
TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries.
Vermeulen FM, Gerbens LAA, Bosma AL, Apfelbacher CJ, Irvine AD, Arents BWM, Barbarot S, Deleuran M, Eichenfield LF, Manca A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Middelkamp-Hup MA, Spuls PI, Flohr C; International TREAT Registry Taskforce. Vermeulen FM, et al. Br J Dermatol. 2019 Sep;181(3):492-504. doi: 10.1111/bjd.17715. Epub 2019 Jun 23. Br J Dermatol. 2019. PMID: 30719709 Free PMC article.
OBJECTIVES: To reach a consensus on how and when to measure the previously defined domain items of the TREatment of ATopic eczema (TREAT) Registry Taskforce core dataset for research registries for paediatric and adult patients with AE. METHODS: Proposals for the me …
OBJECTIVES: To reach a consensus on how and when to measure the previously defined domain items of the TREatment of ATopic eczema (TREAT …
TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries.
Gerbens LAA, Apfelbacher CJ, Irvine AD, Barbarot S, de Booij RJ, Boyce AE, Deleuran M, Eichenfield LF, Hof MH, Middelkamp-Hup MA, Roberts A, Schmitt J, Vestergaard C, Wall D, Weidinger S, Williamson PR, Flohr C, Spuls PI; international TREAT Registry Taskforce. Gerbens LAA, et al. Br J Dermatol. 2019 Apr;180(4):790-801. doi: 10.1111/bjd.16714. Epub 2018 Aug 3. Br J Dermatol. 2019. PMID: 29761486 Free PMC article.
Patient registries provide valuable evidence for the effects of treatments under real-world conditions that can inform treatment guidelines, give the opportunity for health economic evaluation and the evaluation of quality of care, as well as pharmacogenetic and dynamic research, …
Patient registries provide valuable evidence for the effects of treatments under real-world conditions that can inform treatment guidelines, …
[Decreased professional performance and quality of life in patients with moderate-to-severe atopic eczema : Results from the German atopic eczema registry TREATgermany].
Haufe E, Abraham S, Heratizadeh A, Harder I, Zink A, Weisshaar E, Kleinheinz A, von Kiedrowski R, Worm M, Bell M, Wollenberg A, Neubert K, Staubach-Renz P, Hilgers M, Bieber T, Fell I, Homey B, Effendy I, Mempel M, Schäkel K, Beissert S, Weidinger S, Werfel T, Schmitt J. Haufe E, et al. Hautarzt. 2018 Oct;69(10):815-824. doi: 10.1007/s00105-018-4261-z. Hautarzt. 2018. PMID: 30191254 German.
Adults with moderate-to-severe atopic eczema (atopic dermatitis [AD]) are enrolled into TREATgermany and prospectively followed over at least 2 years. This paper analyses the association between dermatological quality of life and work limitations. ...CONCLUSION: Moderate-t …
Adults with moderate-to-severe atopic eczema (atopic dermatitis [AD]) are enrolled into TREATgermany and prospectively followed over …
Einsatz und Wirksamkeit von Systemtherapien bei Erwachsenen mit schwerer Neurodermitis: Erste Ergebnisse des deutschen Neurodermitis-Registers TREATgermany.
Schmitt J, Abraham S, Trautmann F, Stephan V, Fölster-Holst R, Homey B, Bieber T, Novak N, Sticherling M, Augustin M, Kleinheinz A, Elsner P, Weidinger S, Werfel T. Schmitt J, et al. J Dtsch Dermatol Ges. 2017 Jan;15(1):49-60. doi: 10.1111/ddg.12958_g. J Dtsch Dermatol Ges. 2017. PMID: 28140536
HINTERGRUND: Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen und sind als Basis einer evidenzbasierten Gesundheitsversorgung unverzichtbar. METHODIK: Das deutsche Neurodermitis-Register TREATgermany …
HINTERGRUND: Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen un …
Usage and effectiveness of systemic treatments in adults with severe atopic eczema: First results of the German Atopic Eczema Registry TREATgermany.
Schmitt J, Abraham S, Trautmann F, Stephan V, Fölster-Holst R, Homey B, Bieber T, Novak N, Sticherling M, Augustin M, Kleinheinz A, Elsner P, Weidinger S, Werfel T. Schmitt J, et al. J Dtsch Dermatol Ges. 2017 Jan;15(1):49-59. doi: 10.1111/ddg.12958. Epub 2016 Nov 10. J Dtsch Dermatol Ges. 2017. PMID: 27862987
They are an indispensable prerequisite of evidence-based health care. METHODS: Initiated in 2011, the German Atopic Dermatitis Registry TREATgermany is the first registry of patients with severe atopic dermatitis worldwide. ...CONCLUSIONS: The present analysi …
They are an indispensable prerequisite of evidence-based health care. METHODS: Initiated in 2011, the German Atopic Dermatitis Registry …