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144 results

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Page 1
Quantifying Effects Of Lifestyle Changes On Progression To Advanced Age-Related Macular Degeneration In High Genetic Risk Individuals.
Seddon JM, De D, Rosner B. Seddon JM, et al. Ophthalmology. 2025 Oct 9:S0161-6420(25)00619-0. doi: 10.1016/j.ophtha.2025.09.030. Online ahead of print. Ophthalmology. 2025. PMID: 41076031
PURPOSE: We examined the extent to which adopting healthy lifestyle behaviors could offset high genetic risk for progression to advanced age-related macular degeneration (AMD), to address concerns of family members of affected patients. ...Cox proportional hazard ra …
PURPOSE: We examined the extent to which adopting healthy lifestyle behaviors could offset high genetic risk for progression to advanced age …
Quantifying Effects of Lifestyle Changes on Progression to Advanced Age-Related Macular Degeneration in High Genetic Risk Individuals.
Seddon JM, De D, Rosner B. Seddon JM, et al. medRxiv [Preprint]. 2025 Jun 18:2025.06.18.25329367. doi: 10.1101/2025.06.18.25329367. medRxiv. 2025. Update in: Ophthalmology. 2025 Oct 9:S0161-6420(25)00619-0. doi: 10.1016/j.ophtha.2025.09.030. PMID: 40585168 Free PMC article. Updated. Preprint.
PURPOSE: We examined the extent to which adopting healthy lifestyle behaviors could offset high genetic risk for progression to advanced age-related macular degeneration (AMD), to address concerns of family members of affected patients. ...Cox proportional hazard ra …
PURPOSE: We examined the extent to which adopting healthy lifestyle behaviors could offset high genetic risk for progression to advanced age …
Role of alpha-1 antitrypsin in Bruch's membrane integrity.
Cheng SY, Giguere D, Silverstein I, Conza A, Seddon JM, Kim S, Iwata T, Mueller C, Punzo C. Cheng SY, et al. Among authors: seddon jm. Sci Rep. 2025 Apr 10;15(1):12223. doi: 10.1038/s41598-025-96570-x. Sci Rep. 2025. PMID: 40210893 Free PMC article.
Studies suggest that AAT augmentation therapy may benefit multiple eye diseases, including age-related macular degeneration (AMD). However, the function of endogenous AAT in the eye remains unclear. ...
Studies suggest that AAT augmentation therapy may benefit multiple eye diseases, including age-related macular degeneration (A …
Clinical and Imaging Characteristics of PRPH2 Retinopathies in a Longitudinal Cohort and Diagnostic Implications.
Seddon JM, De D, Grunenkovaite L, Ferrara D. Seddon JM, et al. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):31. doi: 10.1167/iovs.65.14.31. Invest Ophthalmol Vis Sci. 2024. PMID: 39693084 Free PMC article.
RESULTS: Two pathogenic/likely pathogenic PRPH2 variants were identified in 22 individuals with retinopathies, low genetic susceptibility to age-related macular degeneration (AMD) and younger age of onset. The mean follow-up was 14 years. One family and 4 independen …
RESULTS: Two pathogenic/likely pathogenic PRPH2 variants were identified in 22 individuals with retinopathies, low genetic susceptibility to …
The role of nutritional factors in transitioning between early, mid, and late stages of age-related macular degeneration: prospective longitudinal analysis.
Seddon JM, De D, Rosner B. Seddon JM, et al. Am J Clin Nutr. 2024 Dec;120(6):1387-1398. doi: 10.1016/j.ajcnut.2024.08.019. Epub 2024 Aug 23. Am J Clin Nutr. 2024. PMID: 39181206 Free PMC article.
BACKGROUND: Transitions between different stages of age-related macular degeneration (AMD) are not completely captured by traditional survival models with an end point of advanced AMD. ...Cox proportional hazards models for foods and nutrients were analyzed adjustin …
BACKGROUND: Transitions between different stages of age-related macular degeneration (AMD) are not completely captured by trad …
Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration.
Seddon JM, De D, Casazza W, Cheng SY, Punzo C, Daly M, Zhou D, Coss SL, Atkinson JP, Yu CY. Seddon JM, et al. Front Genet. 2024 Jan 29;14:1274743. doi: 10.3389/fgene.2023.1274743. eCollection 2023. Front Genet. 2024. PMID: 38348408 Free PMC article.
Introduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. ...
Introduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. ...
Family History of Age-Related Macular Degeneration and Genetics Predict Progression to Advanced Age-Related Macular Degeneration Adjusting for Macular Status, Demographic, and Lifestyle Factors.
Seddon JM, De D, Rosner B. Seddon JM, et al. Am J Ophthalmol. 2023 Nov;255:74-86. doi: 10.1016/j.ajo.2023.06.017. Epub 2023 Jul 10. Am J Ophthalmol. 2023. PMID: 37437830 Free PMC article.
PURPOSE: To determine if a family history of age-related macular degeneration (AMD) and genetic variants identify eyes at higher risk for progression to advanced AMD (AAMD), after controlling for baseline demographics, behavioral factors, and macular status. …
PURPOSE: To determine if a family history of age-related macular degeneration (AMD) and genetic variants identify eyes at high …
Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular Degeneration.
Seddon JM, Rosner B, De D, Huan T, Java A, Atkinson J. Seddon JM, et al. Ophthalmol Sci. 2022 Dec 30;3(2):100265. doi: 10.1016/j.xops.2022.100265. eCollection 2023 Jun. Ophthalmol Sci. 2022. PMID: 36909148 Free PMC article.
PURPOSE: To evaluate associations between rare dysfunctional complement factor I (CFI) genetic variant status and progression to advanced age-related macular degeneration (AAMD), geographic atrophy (GA), and neovascular disease (NV). DESIGN: Prospective, longitudina …
PURPOSE: To evaluate associations between rare dysfunctional complement factor I (CFI) genetic variant status and progression to advanced ag …
Blue Light Exposure: Ocular Hazards and Prevention-A Narrative Review.
Cougnard-Gregoire A, Merle BMJ, Aslam T, Seddon JM, Aknin I, Klaver CCW, Garhöfer G, Layana AG, Minnella AM, Silva R, Delcourt C. Cougnard-Gregoire A, et al. Among authors: seddon jm. Ophthalmol Ther. 2023 Apr;12(2):755-788. doi: 10.1007/s40123-023-00675-3. Epub 2023 Feb 18. Ophthalmol Ther. 2023. PMID: 36808601 Free PMC article. Review.
Regarding protection, there is currently no evidence of a beneficial effect of blue blocking lenses for the prevention of eye diseases, in particular age-related macular degeneration (AMD). In humans, macular pigments (composed of lutein and zeaxanthin) repre …
Regarding protection, there is currently no evidence of a beneficial effect of blue blocking lenses for the prevention of eye diseases, in p …
Deep ensemble learning for automated non-advanced AMD classification using optimized retinal layer segmentation and SD-OCT scans.
Moradi M, Chen Y, Du X, Seddon JM. Moradi M, et al. Among authors: seddon jm. Comput Biol Med. 2023 Mar;154:106512. doi: 10.1016/j.compbiomed.2022.106512. Epub 2023 Jan 10. Comput Biol Med. 2023. PMID: 36701964 Free PMC article.
BACKGROUND: Accurate retinal layer segmentation in optical coherence tomography (OCT) images is crucial for quantitatively analyzing age-related macular degeneration (AMD) and monitoring its progression. However, previous retinal segmentation models depend on experi …
BACKGROUND: Accurate retinal layer segmentation in optical coherence tomography (OCT) images is crucial for quantitatively analyzing age-rel …
144 results