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[11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects.
Slifstein M, Kegeles LS, Gonzales R, Frankle WG, Xu X, Laruelle M, Abi-Dargham A. Slifstein M, et al. J Cereb Blood Flow Metab. 2007 Oct;27(10):1733-41. doi: 10.1038/sj.jcbfm.9600468. Epub 2007 Feb 21. J Cereb Blood Flow Metab. 2007. PMID: 17311076
The dopamine D(1) receptor antagonist radioligand [(11)C]NNC 112 has previously been reported to have 100-fold selectivity for the D(1) receptor compared with the serotonin 5-HT(2A) receptor. ...Based on the known relative densities of these receptors in humans, our …
The dopamine D(1) receptor antagonist radioligand [(11)C]NNC 112 has previously been reported to have 100-fold selectivity for …
(+)-8-Chloro-5-(7-benzofuranyl)-7-hydroxy-3-[11C]methyl-2,3,4,5-tetrahydro-1H-3-benzazepine.
Leung K. Leung K. 2006 Mar 17 [updated 2008 Jan 12]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2006 Mar 17 [updated 2008 Jan 12]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641216 Free Books & Documents. Review.
. (+)-8-Chloro-5-(7-benzofuranyl)-7-hydroxy-3-[(11)C]methyl-2,3,4,5-tetrahydro-1H-3-benzazepine ([(11)C]NNC 112) was also found to be a selective, high-affinity antagonist of D(1) receptors, but to have only a marginal effect on D(2), alpha(1)-adrenergic, muscarinic …
. (+)-8-Chloro-5-(7-benzofuranyl)-7-hydroxy-3-[(11)C]methyl-2,3,4,5-tetrahydro-1H-3-benzazepine ([(11)C]NNC 112) was also foun …
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA.
Cropley VL, Fujita M, Bara-Jimenez W, Brown AK, Zhang XY, Sangare J, Herscovitch P, Pike VW, Hallett M, Nathan PJ, Innis RB. Cropley VL, et al. Psychiatry Res. 2008 Jul 15;163(2):171-82. doi: 10.1016/j.pscychresns.2007.11.003. Epub 2008 May 27. Psychiatry Res. 2008. PMID: 18504119
Fifteen non-demented PD patients and 14 healthy controls underwent [(18)F]FDOPA (for dopamine synthesis) and [(11)C]NNC 112 (for D(1) receptors) PET scans and cognitive testing. Parametric images of [(18)F]FDOPA uptake (K(i)) and [(11)C]NNC 112 binding …
Fifteen non-demented PD patients and 14 healthy controls underwent [(18)F]FDOPA (for dopamine synthesis) and [(11)C]NNC 112 (f …
Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1-dopamine receptors.
Halldin C, Foged C, Chou YH, Karlsson P, Swahn CG, Sandell J, Sedvall G, Farde L. Halldin C, et al. J Nucl Med. 1998 Dec;39(12):2061-8. J Nucl Med. 1998. PMID: 9867142 Free article.
The fraction of the total radioactivity in human plasma representing unchanged (+)-[11C]NNC 112 was 85% at 5 min and 25% at 75 min after injection. CONCLUSION: (+)-[11C]NNC 112 should be a useful PET radioligand for quantitative examinati …
The fraction of the total radioactivity in human plasma representing unchanged (+)-[11C]NNC 112 was 85% at 5 min and 25 …
Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112.
Cannon DM, Klaver JM, Peck SA, Rallis-Voak D, Erickson K, Drevets WC. Cannon DM, et al. Neuropsychopharmacology. 2009 Apr;34(5):1277-87. doi: 10.1038/npp.2008.194. Epub 2008 Oct 22. Neuropsychopharmacology. 2009. PMID: 18946469 Free PMC article.
To date, however, selective in vivo assessment of D(1) receptors has been limited to the striatum in MDD samples manifesting anger attacks. We employed the PET radioligand, [(11)C]NNC-112, to selectively assess D(1) receptor binding in extrastriatal and striatal reg …
To date, however, selective in vivo assessment of D(1) receptors has been limited to the striatum in MDD samples manifesting anger attacks. …
Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans.
Cropley VL, Fujita M, Musachio JL, Hong J, Ghose S, Sangare J, Nathan PJ, Pike VW, Innis RB. Cropley VL, et al. J Nucl Med. 2006 Jan;47(1):100-4. J Nucl Med. 2006. PMID: 16391193 Free article. Clinical Trial.
The present study estimated radiation-absorbed doses of the dopamine D(1) receptor radioligand [(11)C]((+)-8-chloro-5-(7-benzofuranyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) (NNC 112) in humans, based on dynamic whole-body PET in healthy subjects. M …
The present study estimated radiation-absorbed doses of the dopamine D(1) receptor radioligand [(11)C]((+)-8-chloro-5-(7-benzofuranyl)-7-hyd …
Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility.
Abi-Dargham A, Martinez D, Mawlawi O, Simpson N, Hwang DR, Slifstein M, Anjilvel S, Pidcock J, Guo NN, Lombardo I, Mann JJ, Van Heertum R, Foged C, Halldin C, Laruelle M. Abi-Dargham A, et al. J Cereb Blood Flow Metab. 2000 Feb;20(2):225-43. doi: 10.1097/00004647-200002000-00003. J Cereb Blood Flow Metab. 2000. PMID: 10698059 Clinical Trial.
To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [11C]NNC 112 is a promising novel radiotracer for po …
To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable metho …
In vivo DA D(1) receptor selectivity of NNC 112 and SCH 23390.
Ekelund J, Slifstein M, Narendran R, Guillin O, Belani H, Guo NN, Hwang Y, Hwang DR, Abi-Dargham A, Laruelle M. Ekelund J, et al. Mol Imaging Biol. 2007 May-Jun;9(3):117-25. doi: 10.1007/s11307-007-0077-4. Mol Imaging Biol. 2007. PMID: 17473957
PURPOSE: [(11)C]NNC 112 and [(11)C]SCH 23390 are selective positron emission tomography (PET) tracers for visualizing dopamine D(1) receptors. ...CONCLUSION: We conclude that about 1/4 of the cortical signal of both [(11)C]NNC 112 and [(11)C]SCH 23390 …
PURPOSE: [(11)C]NNC 112 and [(11)C]SCH 23390 are selective positron emission tomography (PET) tracers for visualizing dopamine …
The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration--a positron emission tomography examination in the monkey brain.
Finnema SJ, Bang-Andersen B, Jørgensen M, Christoffersen CT, Gulyás B, Wikström HV, Farde L, Halldin C. Finnema SJ, et al. Synapse. 2013 Sep;67(9):586-95. doi: 10.1002/syn.21664. Epub 2013 Apr 18. Synapse. 2013. PMID: 23504964
The aim of this study was to evaluate the dopamine sensitivity of a dopamine D1 receptor agonist radioligand. For this purpose, we developed (S)-[11C]N-methyl-NNC 01-0259 ((S)-[11C]1) and characterized the receptor binding of (S)-[11C]1 using in vitro …
The aim of this study was to evaluate the dopamine sensitivity of a dopamine D1 receptor agonist radioligand. For this purpose, we developed …
Recent advances in PET imaging for evaluation of Parkinson's disease.
Sioka C, Fotopoulos A, Kyritsis AP. Sioka C, et al. Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1594-603. doi: 10.1007/s00259-009-1357-9. Epub 2010 Jan 27. Eur J Nucl Med Mol Imaging. 2010. PMID: 20107789 Review.
Postsynaptically, for the dopamine D(1) subtype the most commonly used ligands are [(11)C]SCH 23390 or [(11)C]NNC 112 and for the D(2) subtype [(11)C]raclopride, [(11)C]MNPA and [(18)F]DMFP. ...
Postsynaptically, for the dopamine D(1) subtype the most commonly used ligands are [(11)C]SCH 23390 or [(11)C]NNC 112 and for …
34 results