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Page 1
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Jena KK, et al. Among authors: broggi a. Cell. 2024 Dec 26;187(26):7533-7550.e23. doi: 10.1016/j.cell.2024.10.010. Epub 2024 Nov 4. Cell. 2024. PMID: 39500322 Free PMC article.
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections.
Ngo C, Pierini-Malosse C, Rahmani K, Valente M, Collinet N, Bessou G, Guerry C, Fabregue M, Mathieu S, Sharkaoui S, Mazzoli S, Sansoni A, Fiore F, Laprie C, Alexopoulou L, Gaya M, Gregoire C, Broggi A, Wurbel S, Rua R, Haidar N, Milpied P, Escalière B, Vu Manh TP, Fallet M, Chasson L, Tran H, Baranek T, Le Bert M, Malissen B, Zarubica A, Dalod M, Tomasello E. Ngo C, et al. Among authors: broggi a. Nat Immunol. 2025 Nov;26(11):1962-1976. doi: 10.1038/s41590-025-02288-3. Epub 2025 Sep 29. Nat Immunol. 2025. PMID: 41023479 Free PMC article.
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis.
Millet V, Gensollen T, Maltese M, Serrero M, Lesavre N, Bourges C, Pitaval C, Cadra S, Chasson L, Vu Man TP, Masse M, Martinez-Garcia JJ, Tranchida F, Shintu L, Mostert K, Strauss E, Lepage P, Chamaillard M, Broggi A, Peyrin-Biroulet L, Grimaud JC, Naquet P, Galland F. Millet V, et al. Among authors: broggi a. Gut. 2023 Jun;72(6):1115-1128. doi: 10.1136/gutjnl-2021-325792. Epub 2022 Sep 29. Gut. 2023. PMID: 36175116
Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection.
Roger A, Fohrer T, Mardelle U, Thomas I, Nezhad ST, Gupta S, Dory A, Jeyanathan V, Liaghat A, Mielle J, Khlifi HM, Santamaria JC, Brunet E, Gouilly J, Escaliere B, Bretaud N, Crosson T, Barbon PV, Mossadegh-Keller N, Irla M, Basta S, Broggi A, Milpied P, Gour N, Feuillet V, Hoeffel G, Dong X, Kaufmann E, Reynders A, Talbot S, Moqrich A, Ugolini S. Roger A, et al. Among authors: broggi a. Immunity. 2026 Mar 10;59(3):682-699.e8. doi: 10.1016/j.immuni.2026.01.022. Epub 2026 Feb 25. Immunity. 2026. PMID: 41747735 Free article.
The interferon landscape along the respiratory tract impacts the severity of COVID-19.
Sposito B, Broggi A, Pandolfi L, Crotta S, Clementi N, Ferrarese R, Sisti S, Criscuolo E, Spreafico R, Long JM, Ambrosi A, Liu E, Frangipane V, Saracino L, Bozzini S, Marongiu L, Facchini FA, Bottazzi A, Fossali T, Colombo R, Clementi M, Tagliabue E, Chou J, Pontiroli AE, Meloni F, Wack A, Mancini N, Zanoni I. Sposito B, et al. Among authors: broggi a. Cell. 2021 Sep 16;184(19):4953-4968.e16. doi: 10.1016/j.cell.2021.08.016. Epub 2021 Aug 19. Cell. 2021. PMID: 34492226 Free PMC article.