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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 3
1989 2
1990 2
1991 8
1992 4
1993 5
1994 13
1995 5
1996 8
1997 22
1998 26
1999 28
2000 33
2001 37
2002 37
2003 36
2004 32
2005 41
2006 52
2007 57
2008 54
2009 50
2010 55
2011 58
2012 65
2013 97
2014 164
2015 182
2016 172
2017 186
2018 192
2019 201
2020 216
2021 247
2022 19
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2,150 results
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Page 1
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. Jack CR Jr, et al. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. Alzheimers Dement. 2018. PMID: 29653606 Free PMC article. Review.
In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease. ...In the National Institute on Aging and Alzheimer
In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, …
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR Jr; Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA. Dubois B, et al. Alzheimers Dement. 2016 Mar;12(3):292-323. doi: 10.1016/j.jalz.2016.02.002. Alzheimers Dement. 2016. PMID: 27012484 Free PMC article. Review.
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at t …
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as …
The neuropathological diagnosis of Alzheimer's disease.
DeTure MA, Dickson DW. DeTure MA, et al. Mol Neurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. Mol Neurodegener. 2019. PMID: 31375134 Free PMC article. Review.
Alzheimer's disease is the most common cause of dementia globally. ...Other disease processes that are frequent, but not inevitable, are also discussed, including pathologic processes that can clinically mimic Alzheimer's disease. ...
Alzheimer's disease is the most common cause of dementia globally. ...Other disease processes that are frequent, but no
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.
Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Yamazaki Y, et al. Nat Rev Neurol. 2019 Sep;15(9):501-518. doi: 10.1038/s41582-019-0228-7. Epub 2019 Jul 31. Nat Rev Neurol. 2019. PMID: 31367008 Free PMC article. Review.
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*epsilon4 allele conferring an increased risk and the APOE*epsilon2 allele conferring a decreased risk relative to the common APOE …
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), wit …
Alzheimer's disease neuroimaging.
Whitwell JL. Whitwell JL. Curr Opin Neurol. 2018 Aug;31(4):396-404. doi: 10.1097/WCO.0000000000000570. Curr Opin Neurol. 2018. PMID: 29762152 Review.
PURPOSE OF REVIEW: The aim of this study was to discuss the contribution of neuroimaging studies to our understanding of Alzheimer's disease. We now have the capability of measuring both tau and beta-amyloid (Abeta) proteins in the brain, which together with more tr …
PURPOSE OF REVIEW: The aim of this study was to discuss the contribution of neuroimaging studies to our understanding of Alzheimer's …
Understanding the impact of sex and gender in Alzheimer's disease: A call to action.
Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, Mallampalli MP, Mormino EC, Scott L, Yu WH, Maki PM, Mielke MM. Nebel RA, et al. Alzheimers Dement. 2018 Sep;14(9):1171-1183. doi: 10.1016/j.jalz.2018.04.008. Epub 2018 Jun 12. Alzheimers Dement. 2018. PMID: 29907423 Free PMC article. Review.
INTRODUCTION: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated …
INTRODUCTION: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, pro …
Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment.
Liu S, Gao J, Zhu M, Liu K, Zhang HL. Liu S, et al. Mol Neurobiol. 2020 Dec;57(12):5026-5043. doi: 10.1007/s12035-020-02073-3. Epub 2020 Aug 23. Mol Neurobiol. 2020. PMID: 32829453 Free PMC article. Review.
Although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, and insulin resistance in the pathogenesis of Alzheimer's …
Although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis …
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade.
Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Jack CR Jr, et al. Lancet Neurol. 2010 Jan;9(1):119-28. doi: 10.1016/S1474-4422(09)70299-6. Lancet Neurol. 2010. PMID: 20083042 Free PMC article.
Currently available evidence strongly supports the position that the initiating event in Alzheimer's disease (AD) is related to abnormal processing of beta-amyloid (Abeta) peptide, ultimately leading to formation of Abeta plaques in the brain. ...Neurodegeneration i …
Currently available evidence strongly supports the position that the initiating event in Alzheimer's disease (AD) is related t …
On the path to 2025: understanding the Alzheimer's disease continuum.
Aisen PS, Cummings J, Jack CR Jr, Morris JC, Sperling R, Frölich L, Jones RW, Dowsett SA, Matthews BR, Raskin J, Scheltens P, Dubois B. Aisen PS, et al. Alzheimers Res Ther. 2017 Aug 9;9(1):60. doi: 10.1186/s13195-017-0283-5. Alzheimers Res Ther. 2017. PMID: 28793924 Free PMC article. Review.
Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes begin many years prior to clinical manifestations of disease and the spectrum of …
Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer's disease (AD). I …
Mild cognitive impairment as a diagnostic entity.
Petersen RC. Petersen RC. J Intern Med. 2004 Sep;256(3):183-94. doi: 10.1111/j.1365-2796.2004.01388.x. J Intern Med. 2004. PMID: 15324362 Free article. Review.
Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) in MCI subjects and certain predictor variables appear valid. ...
Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) …
2,150 results