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The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.
Mikhaylova M, Vakhitova JV, Yamidanov RS, Salimgareeva MKh, Seredenin SB, Behnisch T. Mikhaylova M, et al. Neuropharmacology. 2007 Oct;53(5):601-8. doi: 10.1016/j.neuropharm.2007.07.001. Epub 2007 Jul 17. Neuropharmacology. 2007. PMID: 17854844
We found that ladasten differentially regulates tyrosine hydroxylase mRNA and protein as well as dopamine and L-DOPA content. We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 …
We found that ladasten differentially regulates tyrosine hydroxylase mRNA and protein as well as dopamine and L-DOPA content. We then …
Psychotropic effects of sidnocarb and ladasten in inbred mice with different reaction to emotional stress.
Levina MN. Levina MN. Bull Exp Biol Med. 2005 Mar;139(3):337-9. doi: 10.1007/s10517-005-0288-0. Bull Exp Biol Med. 2005. PMID: 16027847 English, Russian.
Ladasten in a dose of 10 mg/kg produced activating and anxiolytic effects on BALB/c mice in the open field test. Combined injection of Ladasten (10 mg/kg) and sidnocarb (6 or 12 mg/kg) activated animal behavior in both tests....
Ladasten in a dose of 10 mg/kg produced activating and anxiolytic effects on BALB/c mice in the open field test. Combined injection o
Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.
Tallerova AV, Kovalenko LP, Durnev AD, Seredenin SB. Tallerova AV, et al. Bull Exp Biol Med. 2011 Nov;152(1):58-60. doi: 10.1007/s10517-011-1453-2. Bull Exp Biol Med. 2011. PMID: 22803040 English, Russian.
Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. ...Further studies should be performed to develop new indications for the use of ladasten in adjuvant therapy of depression....
Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. ...F
Toxic effect of single treatment with bromantane on neurological status of experimental animals.
Iezhitsa IN, Spasov AA, Bugaeva LI, Morozov IS. Iezhitsa IN, et al. Bull Exp Biol Med. 2002 Apr;133(4):380-3. doi: 10.1023/a:1016206306875. Bull Exp Biol Med. 2002. PMID: 12124651
In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals bromantane in high doses induced regurgitation, diarrhea, and polyuria. ...
In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals broman
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.
Oliynyk S, Oh S. Oliynyk S, et al. Biomol Ther (Seoul). 2012 Sep;20(5):446-56. doi: 10.4062/biomolther.2012.20.5.446. Biomol Ther (Seoul). 2012. PMID: 24009833 Free PMC article. Review.
A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these …
A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is …
[Pilot clinical trial of ladasten].
Siuniakov SA, Grishin SA, Teleshova ES, Neznamov GG, Seredenin SB. Siuniakov SA, et al. Eksp Klin Farmakol. 2006 Jul-Aug;69(4):10-5. Eksp Klin Farmakol. 2006. PMID: 16995430 Clinical Trial. Russian.
Ladasten exhibits a unique combination of therapeutically significant stimulant and anxiolytic effects, which is unusual of psychostimulants. ...Ladasten shows high efficacy in the treatment of these disorders testify and has good prospects for practical application
Ladasten exhibits a unique combination of therapeutically significant stimulant and anxiolytic effects, which is unusual of psychosti
[Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten].
Vakhitova IuV, Sadovnikov SV, Iamidanov RS, Seredenin SB. Vakhitova IuV, et al. Genetika. 2006 Jul;42(7):968-75. Genetika. 2006. PMID: 16915929 Russian.
In the present study, we employed the bisulfate sequencing technique to detect changes of GpG islands methylation status in the TH gene 5'-flanking region (-650 + 84) in hypothalamus cells of control and experimental rats after a single exposure to Ladasten. Ladasten
In the present study, we employed the bisulfate sequencing technique to detect changes of GpG islands methylation status in the TH gene 5'-f …
[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia].
Sedov AV, Lukicheva TA, Surovtsev NA, Akin'shin AV, Nazarov LIu, Miroshnik SV. Sedov AV, et al. Med Tr Prom Ekol. 1993;(9-10):10-1. Med Tr Prom Ekol. 1993. PMID: 8087458 Russian.
A group of volunteers was exposed to coaction of carbon dioxide (concentration 300 mg/cu m) and heating microclimate (ambient temperature +50 +/- 2 degrees C, relative humidity 20 +/- 5%), simultaneously they received one of the medicines: placebo, bemitil (0.5 g), bromantane
A group of volunteers was exposed to coaction of carbon dioxide (concentration 300 mg/cu m) and heating microclimate (ambient temperature +5 …
Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.
Tallerova AV, Kovalenko LP, Kuznetsova OS, Durnev AD, Seredenin SB. Tallerova AV, et al. Bull Exp Biol Med. 2014 Jan;156(3):335-7. doi: 10.1007/s10517-014-2343-1. Epub 2014 Jan 16. Bull Exp Biol Med. 2014. PMID: 24771370
We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 …
We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompet …
[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types].
Neznamov GG, Bochkarev VK, Reutova MA, Shabanova AA, Siuniakov SA. Neznamov GG, et al. Eksp Klin Farmakol. 2012;75(5):7-13. Eksp Klin Farmakol. 2012. PMID: 22834121 Clinical Trial. Russian.
The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG alpha rhythm organization and personal traits with respect to tolerability, wish to continue the treatment, activating and calming effects. I …
The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG a …
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