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2023 3
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CYP1B1 promotes PARPi-resistance via histone H1.4 interaction and increased chromatin accessibility in ovarian cancer.
Xue Y, Yin T, Yuan S, Wang L, Lin H, Jin T, Xu R, Gu J, Shen S, Chen X, Chen Z, Sima N, Chen L, Lu W, Li X, Cheng X, Wang H. Xue Y, et al. Drug Resist Updat. 2024 Nov;77:101151. doi: 10.1016/j.drup.2024.101151. Epub 2024 Sep 12. Drug Resist Updat. 2024. PMID: 39395328 Free article.
RESULTS: The gradual exposure of Olaparib has developed a PARPi-resistant cell line, A2780-OlaR, which exhibits significant upregulation of CYP1B1 at both RNA and protein levels. Down-regulating CYP1B1 expression or using specific inhibitors decreased the cellular r …
RESULTS: The gradual exposure of Olaparib has developed a PARPi-resistant cell line, A2780-OlaR, which exhibits significant upregulation of …
Integrating Genetics in Glaucoma Screening.
Mackey DA, Bigirimana D, Staffieri SE. Mackey DA, et al. J Glaucoma. 2024 Aug 1;33(Suppl 1):S49-S53. doi: 10.1097/IJG.0000000000002425. Epub 2024 Aug 19. J Glaucoma. 2024. PMID: 39149951 Free PMC article. Review.
METHODS/RESULTS: Over the last 2 and a half decades, glaucoma genetics has evolved from identifying genes with Mendelian inheritance patterns, such as myocilin and CYP1B1, to the discovery of hundreds of genes associated with the disease. Polygenic risk scores have been de …
METHODS/RESULTS: Over the last 2 and a half decades, glaucoma genetics has evolved from identifying genes with Mendelian inheritance pattern …
Human Cytochrome P450 Cancer-Related Metabolic Activities and Gene Polymorphisms: A Review.
Mokhosoev IM, Astakhov DV, Terentiev AA, Moldogazieva NT. Mokhosoev IM, et al. Cells. 2024 Nov 26;13(23):1958. doi: 10.3390/cells13231958. Cells. 2024. PMID: 39682707 Free PMC article. Review.
Key players in these mechanisms are the 2,3- and 3,4-catechols of estrogens, which are formed by CYP1A1, CYP1A2, and CYP1B1. The catechols can also produce quinones, leading to the formation of toxic protein and DNA adducts that contribute to cancer progression. ...
Key players in these mechanisms are the 2,3- and 3,4-catechols of estrogens, which are formed by CYP1A1, CYP1A2, and CYP1B1. The cate …
Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning.
Xiao L, He R, Hu K, Song G, Han S, Lin J, Chen Y, Zhang D, Wang W, Peng Y, Zhang J, Yu P. Xiao L, et al. Apoptosis. 2024 Aug;29(7-8):1070-1089. doi: 10.1007/s10495-024-01960-7. Epub 2024 Apr 14. Apoptosis. 2024. PMID: 38615305
Subsequently, seven PCD-related features, especially CD28, CYP1B1, JAK3, LAMP3, SFN, STAT4, and TRAF1, were utilized to establish the prognostic signature, namely cell death index (CDI). ...
Subsequently, seven PCD-related features, especially CD28, CYP1B1, JAK3, LAMP3, SFN, STAT4, and TRAF1, were utilized to establish the …
CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.
Nho K, Risacher SL, Apostolova LG, Bice PJ, Brosch JR, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR Jr, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Ertekin-Taner N, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI); Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ. Nho K, et al. Nat Commun. 2024 Sep 20;15(1):8251. doi: 10.1038/s41467-024-52298-2. Nat Commun. 2024. PMID: 39304655 Free PMC article.
Additive effects, but no interactions, are observed between rs2113389 and diagnosis, APOE4, and amyloid beta positivity. CYP1B1 expression is upregulated in AD. rs2113389 is associated with higher CYP1B1 expression and methylation levels. Mouse model studies provide …
Additive effects, but no interactions, are observed between rs2113389 and diagnosis, APOE4, and amyloid beta positivity. CYP1B1 expre …
Congenital anterior segment ocular disorders: Genotype-phenotype correlations and emerging novel mechanisms.
Reis LM, Seese SE, Costakos D, Semina EV. Reis LM, et al. Prog Retin Eye Res. 2024 Sep;102:101288. doi: 10.1016/j.preteyeres.2024.101288. Epub 2024 Aug 2. Prog Retin Eye Res. 2024. PMID: 39097141 Free PMC article. Review.
While some genes are strongly associated with a specific clinical diagnosis, the majority of known factors are linked with highly variable phenotypic presentations, with pathogenic variants in FOXC1, CYP1B1, and PITX2 associated with the broadest spectrum of ASD conditions …
While some genes are strongly associated with a specific clinical diagnosis, the majority of known factors are linked with highly variable p …
Potential Involvements of Cilia-Centrosomal Genes in Primary Congenital Glaucoma.
Pyatla G, Kabra M, Mandal AK, Zhang W, Mishra A, Bera S, Rathi S, Patnaik S, Anthony AA, Dixit R, Banerjee S, Shekhar K, Marmamula S, Kaur I, Khanna RC, Chakrabarti S. Pyatla G, et al. Int J Mol Sci. 2024 Sep 18;25(18):10028. doi: 10.3390/ijms251810028. Int J Mol Sci. 2024. PMID: 39337513 Free PMC article.
Previous studies have implicated rare variants in CYP1B1, LTBP2, and TEK and their interactions with MYOC, FOXC1, and PRSS56 in the genetic complexity and clinical heterogeneity of PCG. ...Co-occurrences of heterozygous alleles of CEP164 with other genes were seen in four …
Previous studies have implicated rare variants in CYP1B1, LTBP2, and TEK and their interactions with MYOC, FOXC1, and PRSS56 in the g …
Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management.
Silva IMD, Vacario BGL, Okuyama NCM, Barcelos GRM, Fuganti PE, Guembarovski RL, Cólus IMS, Serpeloni JM. Silva IMD, et al. Gene. 2024 May 20;907:148252. doi: 10.1016/j.gene.2024.148252. Epub 2024 Feb 11. Gene. 2024. PMID: 38350514 Review.
The most studied candidate genes/loci of phase I metabolism were CYP1B1, CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2A6, CYP3E1, and ALDH2, and those in phase II were GSTM1, GSTT1, NAT2, GSTP1, GSTA1, GSTO1, and UGT1A1. ...
The most studied candidate genes/loci of phase I metabolism were CYP1B1, CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2A6, CYP3E1, and ALDH2, a …
Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial.
Strømland PP, Bertelsen BE, Viste K, Chatziioannou AC, Bellerba F, Robinot N, Trolat A, Flågeng MH, Scalbert A, Keski-Rahkonen P, Sears DD, Bonanni B, Gandini S, Johansson H, Mellgren G. Strømland PP, et al. Sci Rep. 2025 May 15;15(1):16897. doi: 10.1038/s41598-025-01705-9. Sci Rep. 2025. PMID: 40374694 Free PMC article. Clinical Trial.
The integration of transcriptomic and steroid hormone profiles showed an enrichment of steroid hormone biosynthesis and metabolism pathways with highly negatively correlated CYP11A1 and CYP1B1 expression in breast tissue from postmenopausal metformin-treated women. Our res …
The integration of transcriptomic and steroid hormone profiles showed an enrichment of steroid hormone biosynthesis and metabolism pathways …
Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia.
Rayinda T, McSweeney SM, Christou E, Ung CY, Fenton DA, McGrath JA, Dand N, Simpson MA, Tziotzios C. Rayinda T, et al. JAMA Dermatol. 2024 Jul 1;160(7):732-735. doi: 10.1001/jamadermatol.2024.1315. JAMA Dermatol. 2024. PMID: 38809548 Free PMC article.
An association between female FFA and the CYP1B1 risk allele was observed in individuals who reported OCP use (odds ratio, 1.90 [95% CI, 1.50-2.40]; P = 8.41 10-8) but not in those with no documented exposure to OCPs (odds ratio, 1.16 [95% CI, 0.82-1.64]; P = .39). ...CONC …
An association between female FFA and the CYP1B1 risk allele was observed in individuals who reported OCP use (odds ratio, 1.90 [95% …
78 results