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48 results

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Page 1
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Among authors: chami m. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Peripheral alterations of mitochondrial function and mitophagy in Alzheimer's disease: from fundamental research to clinical perspectives.
Eysert F, Deportes G, Delaquaize E, Chami M. Eysert F, et al. Among authors: chami m. Curr Opin Neurol. 2026 Apr 1;39(2):185-191. doi: 10.1097/WCO.0000000000001457. Epub 2026 Jan 29. Curr Opin Neurol. 2026. PMID: 41623082 Review.
PURPOSE OF REVIEW: Alzheimer's disease (AD) is commonly defined by its hallmark brain pathologies, yet mounting evidence shows that metabolic impairment particularly linked to mitochondrial dysfunction, is a central and systemic feature of the disease. …
PURPOSE OF REVIEW: Alzheimer's disease (AD) is commonly defined by its hallmark brain pathologies, yet mounting evidenc …
Calcium Signalling in Alzheimer's Disease: From Pathophysiological Regulation to Therapeutic Approaches.
Chami M. Chami M. Cells. 2021 Jan 12;10(1):140. doi: 10.3390/cells10010140. Cells. 2021. PMID: 33445705 Free PMC article.
Alzheimer's disease (AD) is a neurodegenerative pathology representing a socioeconomic challenge, however, the complex mechanism behind the disease is not yet fully understood [...]....
Alzheimer's disease (AD) is a neurodegenerative pathology representing a socioeconomic challenge, however, the complex …
Calcium and apoptosis: facts and hypotheses.
Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T. Rizzuto R, et al. Among authors: chami m. Oncogene. 2003 Nov 24;22(53):8619-27. doi: 10.1038/sj.onc.1207105. Oncogene. 2003. PMID: 14634623 Review.
Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few years the role of calcium in the signaling of apoptosis has been extensively investigated. ...
Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few yea …
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.
Vaillant-Beuchot L, Eysert F, Duval B, Kinoshita PF, Pardossi-Piquard R, Bauer C, Eddarkaoui S, Buée L, Checler F, Chami M. Vaillant-Beuchot L, et al. Among authors: chami m. Cell Death Dis. 2024 May 28;15(5):367. doi: 10.1038/s41419-024-06742-2. Cell Death Dis. 2024. PMID: 38806484 Free PMC article.
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer's disease (AD) related molecular actors including amyloid beta (Abeta) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). ...Importantly, we u …
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer's disease (AD) related mole …
Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin.
Mary A, Barale S, Eysert F, Valverde A, Lacas-Gervais S, Bauer C, Eddarkaoui S, Buée L, Buée-Scherrer V, Checler F, Chami M. Mary A, et al. Among authors: chami m. Alzheimers Res Ther. 2025 Jun 2;17(1):127. doi: 10.1186/s13195-025-01772-0. Alzheimers Res Ther. 2025. PMID: 40457477 Free PMC article.
Furthermore, in the 3xTgAD brains, it reduces the early accumulation of APP C-terminal fragments (APP-CTFs) as well as amyloid beta (Abeta) burden, microgliosis and astrogliosis occurring at a later disease stage. AMPK-ULK1 activation increases the localization of APP-CTFs …
Furthermore, in the 3xTgAD brains, it reduces the early accumulation of APP C-terminal fragments (APP-CTFs) as well as amyloid beta (Abeta) …
Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches.
Mary A, Eysert F, Checler F, Chami M. Mary A, et al. Among authors: chami m. Mol Psychiatry. 2023 Jan;28(1):202-216. doi: 10.1038/s41380-022-01631-6. Epub 2022 Jun 3. Mol Psychiatry. 2023. PMID: 35665766 Free PMC article. Review.
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments in mitophagy, the process of selective mitochondrial degradation by autophagy leading to a gradual accumulation of defective mitochondria, have also been repo …
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments in mitophagy, the …
Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer's Disease.
Chami M, Checler F. Chami M, et al. Cells. 2020 Dec 1;9(12):2577. doi: 10.3390/cells9122577. Cells. 2020. PMID: 33271984 Free PMC article. Review.
Sustained imbalance in intracellular calcium (Ca(2+)) entry and clearance alters cellular integrity, ultimately leading to cellular homeostasis disequilibrium and cell death. Alzheimer's disease (AD) is the most common cause of dementia. Beside the maj …
Sustained imbalance in intracellular calcium (Ca(2+)) entry and clearance alters cellular integrity, ultimately leading to cellular h …
Targeting Post-Translational Remodeling of Ryanodine Receptor: A New Track for Alzheimer's Disease Therapy?
Chami M, Checler F. Chami M, et al. Curr Alzheimer Res. 2020;17(4):313-323. doi: 10.2174/1567205017666200225102941. Curr Alzheimer Res. 2020. PMID: 32096743 Review.
Pathologic calcium (Ca2+) signaling linked to Alzheimer's Disease (AD) involves the intracellular Ca2+ release channels/ryanodine receptors (RyRs). ...
Pathologic calcium (Ca2+) signaling linked to Alzheimer's Disease (AD) involves the intracellular Ca2+ release c …
Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.
Lauritzen I, Bini A, Bécot A, Gay AS, Badot C, Pagnotta S, Chami M, Checler F. Lauritzen I, et al. Among authors: chami m. J Extracell Vesicles. 2025 Jan;14(1):e70019. doi: 10.1002/jev2.70019. J Extracell Vesicles. 2025. PMID: 39815792 Free PMC article.
Here, we questioned the role of presenilins (PSENs 1 and 2), previously shown to be involved in autophagy regulation, in the secretion of small endocytic-originating extracellular vesicles known as exosomes. Indeed, while wild-type cells responded to stimuli promoting both …
Here, we questioned the role of presenilins (PSENs 1 and 2), previously shown to be involved in autophagy regulation, in the secretion of sm …
48 results