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1987 1
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143 results

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Page 1
Intraosseous Pseudoprogression vs. Progression and Recurrence of Clival Chordoma after Proton Radiation Therapy: Case Series.
Hong S, Shinya Y, Mahajan A, Laack NN, Raghunathan A, Mark IT, Van Gompel JJ. Hong S, et al. J Neurol Surg B Skull Base. 2025 Mar 3;87(2):173-181. doi: 10.1055/a-2538-3865. eCollection 2026 Apr. J Neurol Surg B Skull Base. 2025. PMID: 41808979 Free PMC article.
OBJECTIVE: To propose a novel entity of possible intraosseous pseudoprogression in clival chordoma following proton radiation therapy (PRT). METHODS: A total of 38 consecutive patients who underwent surgical resection followed by PRT for clival chordoma between Janu …
OBJECTIVE: To propose a novel entity of possible intraosseous pseudoprogression in clival chordoma following proton radiation therapy …
Cervical spine chordomas: surgical outcome assessment in a multicenter cohort from the Primary Tumor Research and Outcomes Network.
Zaldivar-Jolissaint JF, Chu Kwan W, Fisher CG, Rhines LD, Boriani S, Gasbarrini A, Luzzati A, Wei F, Gokaslan ZL, Bettegowda C, Sciubba DM, Lazary A, Kawahara N, Clarke MJ, Barzilai O, Rampersaud YR, Disch AC, Chou D, Shin JH, Hornicek FJ, Laufer I, Sahgal A, Verlaan JJ, Reynolds J, Dea N. Zaldivar-Jolissaint JF, et al. J Neurosurg Spine. 2026 Jan 30:1-11. doi: 10.3171/2025.9.SPINE25785. Online ahead of print. J Neurosurg Spine. 2026. PMID: 41616303 Free PMC article.
Cervical spine chordomas pose significant surgical challenges given their proximity to critical anatomical structures and the mechanical constraints of the cervical spine. ...CONCLUSIONS: This multicenter case series analysis provides critical insights into the clinical ou …
Cervical spine chordomas pose significant surgical challenges given their proximity to critical anatomical structures and the mechani …
Insights From the AO Spine Knowledge Forum Tumor Registries: Advancing the Understanding and Management of Primary Spine Tumors Through International Multicentric Collaboration. A Narrative Review.
Cecchinato R, Tobert DG, Barzilai O, Bettegowda C, Boriani S, Chou D, Clarke MJ, Dea N, Disch AC, Gasbarrini A, Gokaslan ZL, Lazary A, Luzzati A, Rampersaud YR, Reynolds J, Rhines LD, Sahgal A, Sciubba DM, Shin JH, Wei F, Netzer C, Verlaan JJ, Laufer I, Fisher CG, On Behalf Of The Ao Spine Knowledge Forum Tumor. Cecchinato R, et al. Global Spine J. 2026 Jan 9:21925682261416419. doi: 10.1177/21925682261416419. Online ahead of print. Global Spine J. 2026. PMID: 41512234 Free PMC article. Review.
Key findings emphasize the importance of Enneking-appropriate (EA) resection in improving survival and reducing recurrence in tumors such as chordoma, chondrosarcoma, and osteosarcoma. Genetic markers, including hTERT promoter mutations and rs2305089 SNP, were linked to pr …
Key findings emphasize the importance of Enneking-appropriate (EA) resection in improving survival and reducing recurrence in tumors such as …
Mucinous adenocarcinoma transformed from tailgut cyst: a case report and review of the literature.
Guo Q, Parker JB, Henderson A, Khoor A, Mohseni MM. Guo Q, et al. Front Oncol. 2026 Jan 5;15:1729627. doi: 10.3389/fonc.2025.1729627. eCollection 2025. Front Oncol. 2026. PMID: 41561766 Free PMC article.
However, an MRI was obtained that showed concerns for myxoid neoplasm or chordoma. A biopsy was subsequently performed that revealed mucinous adenocarcinoma. Additionally, on imaging there was an enhancing pelvic lymph node concerning for metastatic spread. ...
However, an MRI was obtained that showed concerns for myxoid neoplasm or chordoma. A biopsy was subsequently performed that revealed …
Comparative Outcomes of Brachyury Vaccine vs. Imatinib in Advanced Chordoma: A Mayo Clinic Experience.
Navarro-Garcia de Llano JP, Iyer HG, Hoffman HC, Seetharam M, Attia S, Akinduro OO. Navarro-Garcia de Llano JP, et al. Cancers (Basel). 2025 Oct 30;17(21):3493. doi: 10.3390/cancers17213493. Cancers (Basel). 2025. PMID: 41228286 Free PMC article.
Background/Objectives: Chordoma, a rare slow-growing malignant bone tumor, remains therapeutically challenging due to its invasive nature. ...Methods: We used data from three sites of our quaternary care academic institution to analyze demographics, time to progression, ov …
Background/Objectives: Chordoma, a rare slow-growing malignant bone tumor, remains therapeutically challenging due to its invasive na …
Impact of proton versus photon radiotherapy on overall survival in the management of spinal chordoma and mortality risk prediction: a nationwide analysis.
Ghaith AK, Yang X, Khalilullah T, Tang L, Radwan H, Weinberg J, Khalifeh J, Ahmed AK, Azad T, Foster C, Theodore N, Redmond KJ, Lubelski D. Ghaith AK, et al. J Neurooncol. 2025 Oct;175(1):405-417. doi: 10.1007/s11060-025-05104-y. Epub 2025 Jun 25. J Neurooncol. 2025. PMID: 40563064
PURPOSE: This study aims to provide a national-level insight into the optimal management of spinal chordoma, a type of rare and complicated malignancy, and to identify effective radiation therapy (RT) strategies for patients with spinal chordoma by comparing photon …
PURPOSE: This study aims to provide a national-level insight into the optimal management of spinal chordoma, a type of rare and compl …
Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors.
Nelson BE, Janku F, Fu S, Dumbrava EE, Hong DS, Karp DD, Naing A, Rodon J, Tsimberidou AM, Murthy R, Sheth RA, Amaria RN, Conley AP, Damodaran S, Raghav KPS, Carapanceanu N, Singh MP, Carapanceanu V, Pezeshki A, Leontovich AA, Kreider BL, Tung D, Varterasian M, Khazaie K, Piha-Paul SA. Nelson BE, et al. Clin Cancer Res. 2025 Sep 15;31(18):3864-3875. doi: 10.1158/1078-0432.CCR-24-3952. Clin Cancer Res. 2025. PMID: 40643985 Free PMC article. Clinical Trial.
The confirmed overall objective response rate of 25% was observed among four patients with nonkeratinizing undifferentiated nasopharyngeal squamous carcinoma, human papilloma virus-positive squamous cell carcinoma of the base of the tongue, vulvar melanoma, and chordoma. A …
The confirmed overall objective response rate of 25% was observed among four patients with nonkeratinizing undifferentiated nasopharyngeal s …
The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.
Groff KJ, Patel RV, Feng Y, Ghosh HS, Millares Chavez MA, O'Brien J, Chen WC, Nitturi V, Save AV, Youngblood MW, Horbinski CM, Chandler JP, Ehret F, Gui C, Wang JZ, Park K, Ajmera S, Rosenblum M, Suwala AK, Kresbach C, Mount CW, Schüller U, Santagata S, Sahm F, Bale TA, Jackson C, Richardson TE, Cai C, Nassiri F, Zadeh G, Kaul D, Capper D, Magill ST, Golfinos JG, Sen C, Patel AJ, Raleigh DR, Moliterno J, Pacione D, Snuderl M, Bi WL. Groff KJ, et al. Lancet Oncol. 2025 Sep;26(9):1178-1190. doi: 10.1016/S1470-2045(25)00422-X. Lancet Oncol. 2025. PMID: 40907515
Exploring perspectives on skull base chordoma management: a modified Delphi approach to consensus.
Myneni S, Ahmed AK, Kazemi F, Saraswathula A, Zwagerman NT, Su SY, Choby G, Wang EW, Van Gompel JJ, Redmond KJ, McKean EL, Snyderman CH, Gardner PA, Rowan NR, Mukherjee D. Myneni S, et al. J Neurooncol. 2025 Sep;174(3):609-620. doi: 10.1007/s11060-025-05088-9. Epub 2025 May 22. J Neurooncol. 2025. PMID: 40402197
Chordomas differ greatly in molecular makeup and proliferation. These factors have led to significant variation in management across providers. We used a modified Delphi approach to work towards consensus on standardized operative definitions and evidence-based management …
Chordomas differ greatly in molecular makeup and proliferation. These factors have led to significant variation in management across …
143 results