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Year Number of Results
1976 2
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1986 3
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1990 8
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1992 5
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1999 3
2000 2
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2002 6
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249 results

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Page 1
Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence.
Honrubia JM, Valverde JR, Muñoz-Santos D, Ripoll-Gómez J, de la Blanca N, Izquierdo J, Villarejo-Torres M, Marchena-Pasero A, Rueda-Huélamo M, Nombela I, Ruiz-Yuste M, Zuñiga S, Sola I, Enjuanes L. Honrubia JM, et al. Among authors: enjuanes l, sola i. Viruses. 2024 Jul 29;16(8):1214. doi: 10.3390/v16081214. Viruses. 2024. PMID: 39205188 Free PMC article.
The interaction between SARS-CoV PDZ-binding motifs (PBMs) and cellular PDZs is responsible for virus virulence. The PBM sequence present in the 3a and envelope (E) proteins of SARS-CoV can potentially bind to over 400 cellular proteins containing PDZ domains. ...Alanine a …
The interaction between SARS-CoV PDZ-binding motifs (PBMs) and cellular PDZs is responsible for virus virulence. The PBM sequence pre …
Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture.
García-Crespo C, de Ávila AI, Gallego I, Soria ME, Durán-Pastor A, Somovilla P, Martínez-González B, Muñoz-Flores J, Mínguez P, Salar-Vidal L, Esteban-Muñoz M, Cañar-Camacho E, Ferrer-Orta C, Zuñiga S, Sola I, Enjuanes L, Esteban J, Fernández-Roblas R, Gadea I, Gómez J, Verdaguer N, Domingo E, Perales C. García-Crespo C, et al. Among authors: enjuanes l, sola i. Br J Pharmacol. 2024 Aug;181(15):2636-2654. doi: 10.1111/bph.16344. Epub 2024 Apr 14. Br J Pharmacol. 2024. PMID: 38616133
KEY RESULTS: Remdesivir and ribavirin exerted a synergistic inhibitory activity against SARS-CoV-2, quantified both by CompuSyn (Chou-Talalay method) and Synergy Finder (ZIP-score model). In serial passage experiments, virus extinction was readily achieved with remdesivir- …
KEY RESULTS: Remdesivir and ribavirin exerted a synergistic inhibitory activity against SARS-CoV-2, quantified both by CompuSyn (Chou-Talala …
Cell type dependent stability and virulence of a recombinant SARS-CoV-2, and engineering of a propagation deficient RNA replicon to analyze virus RNA synthesis.
Wang L, Guzman M, Muñoz-Santos D, Honrubia JM, Ripoll-Gomez J, Delgado R, Sola I, Enjuanes L, Zuñiga S. Wang L, et al. Among authors: enjuanes l, sola i. Front Cell Infect Microbiol. 2023 Oct 24;13:1268227. doi: 10.3389/fcimb.2023.1268227. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37942479 Free PMC article.
Engineering of reverse genetics systems for newly emerged viruses allows viral genome manipulation, being an essential tool for the study of virus life cycle, virus-host interactions and pathogenesis, as well as for the development of effective antiviral stra …
Engineering of reverse genetics systems for newly emerged viruses allows viral genome manipulation, being an essential tool for the s …
SARS-CoV-2 ORF8 accessory protein is a virulence factor.
Bello-Perez M, Hurtado-Tamayo J, Mykytyn AZ, Lamers MM, Requena-Platek R, Schipper D, Muñoz-Santos D, Ripoll-Gómez J, Esteban A, Sánchez-Cordón PJ, Enjuanes L, Haagmans BL, Sola I. Bello-Perez M, et al. Among authors: enjuanes l, sola i. mBio. 2023 Oct 31;14(5):e0045123. doi: 10.1128/mbio.00451-23. Epub 2023 Aug 25. mBio. 2023. PMID: 37623322 Free PMC article.
The relevance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 in the pathogenesis of COVID-19 is unclear. Virus natural isolates with deletions in ORF8 were associated with wild milder disease, suggesting that ORF8 might contribute to SARS-CoV-2 virule …
The relevance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 in the pathogenesis of COVID-19 is unclear. Virus …
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O'Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: enjuanes l. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607224 Free PMC article.
Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein encoded as a small domain at the N terminus of nonstructural protein 3. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical fo …
Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein encoded as a sm …
Dextran sulfate from Leuconostoc mesenteroides B512F exerts potent antiviral activity against SARS-CoV-2 in vitro and in vivo.
Andreu S, von Kobbe C, Delgado P, Ripa I, Buzón MJ, Genescà M, Gironès N, Del Moral-Salmoral J, Ramírez GA, Zúñiga S, Enjuanes L, López-Guerrero JA, Bello-Morales R. Andreu S, et al. Among authors: enjuanes l. Front Microbiol. 2023 May 3;14:1185504. doi: 10.3389/fmicb.2023.1185504. eCollection 2023. Front Microbiol. 2023. PMID: 37206325 Free PMC article.
Dextran sulfate (DS) polysaccharides have long demonstrated antiviral activity against different enveloped viruses in vitro. However, their poor bioavailability has led to their abandonment as antiviral candidates. ...In addition, this exopolysaccharide substance also repo …
Dextran sulfate (DS) polysaccharides have long demonstrated antiviral activity against different enveloped viruses in vitro. However, …
Contribution to pathogenesis of accessory proteins of deadly human coronaviruses.
Hurtado-Tamayo J, Requena-Platek R, Enjuanes L, Bello-Perez M, Sola I. Hurtado-Tamayo J, et al. Among authors: enjuanes l, sola i. Front Cell Infect Microbiol. 2023 May 1;13:1166839. doi: 10.3389/fcimb.2023.1166839. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37197199 Free PMC article. Review.
Accessory proteins are non-essential for virus replication, but are frequently involved in virus-host interactions associated with virulence. ...This review summarizes the current knowledge on human CoV accessory proteins, with an emphasis on their contribution to …
Accessory proteins are non-essential for virus replication, but are frequently involved in virus-host interactions associated …
ICTV Virus Taxonomy Profile: Coronaviridae 2023.
Woo PCY, de Groot RJ, Haagmans B, Lau SKP, Neuman BW, Perlman S, Sola I, van der Hoek L, Wong ACP, Yeh SH. Woo PCY, et al. Among authors: sola i. J Gen Virol. 2023 Apr;104(4). doi: 10.1099/jgv.0.001843. J Gen Virol. 2023. PMID: 37097842
The family Coronaviridae includes viruses with positive-sense RNA genomes of 22-36 kb that are expressed through a nested set of 3' co-terminal subgenomic mRNAs. ...This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family C …
The family Coronaviridae includes viruses with positive-sense RNA genomes of 22-36 kb that are expressed through a nested set of 3' c …
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Among authors: enjuanes l. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120 PMID: 37066301 Free PMC article. Updated. Preprint.
Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine hepatitis virus (MHV) and severe acute respirato …
Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing po …
Efficient CRISPR-Cas13d-Based Antiviral Strategy to Combat SARS-CoV-2.
Hussein M, Andrade Dos Ramos Z, Vink MA, Kroon P, Yu Z, Enjuanes L, Zuñiga S, Berkhout B, Herrera-Carrillo E. Hussein M, et al. Among authors: enjuanes l. Viruses. 2023 Mar 6;15(3):686. doi: 10.3390/v15030686. Viruses. 2023. PMID: 36992394 Free PMC article.
Although protective vaccines are available, concerns remain as new virus variants continue to appear. CRISPR-based gene-editing approaches offer an attractive therapeutic strategy as the CRISPR-RNA (crRNA) can be adjusted rapidly to accommodate a new viral genome sequence. …
Although protective vaccines are available, concerns remain as new virus variants continue to appear. CRISPR-based gene-editing appro …
249 results