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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1978 2
1979 2
1980 3
1981 2
1982 4
1983 2
1984 1
1985 3
1987 2
1989 5
1990 6
1991 2
1992 6
1993 5
1994 5
1995 3
1996 6
1997 12
1998 11
1999 16
2000 16
2001 10
2002 18
2003 9
2004 15
2005 10
2006 10
2007 20
2008 22
2009 21
2010 32
2011 30
2012 47
2013 44
2014 46
2015 30
2016 34
2017 24
2018 29
2019 36
2020 33
2021 34
2022 33
2023 37
2024 42
2025 30
2026 6

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716 results

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Page 1
The inherited cerebellar ataxias: an update.
Coarelli G, Wirth T, Tranchant C, Koenig M, Durr A, Anheim M. Coarelli G, et al. J Neurol. 2023 Jan;270(1):208-222. doi: 10.1007/s00415-022-11383-6. Epub 2022 Sep 24. J Neurol. 2023. PMID: 36152050 Free PMC article. Review.
We also report on key clinical points for the diagnosis of the main ICAs, including Friedreich ataxia, CANVAS, polyglutamine spinocerebellar ataxias, Fragile X-associated tremor/ataxia syndrome. ...Lastly, we describe new therapeutic leads: antisense oligonucleotide …
We also report on key clinical points for the diagnosis of the main ICAs, including Friedreich ataxia, CANVAS, polyglutamine s …
Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.
Lynch DR, Farmer J, Hauser L, Blair IA, Wang QQ, Mesaros C, Snyder N, Boesch S, Chin M, Delatycki MB, Giunti P, Goldsberry A, Hoyle C, McBride MG, Nachbauer W, O'Grady M, Perlman S, Subramony SH, Wilmot GR, Zesiewicz T, Meyer C. Lynch DR, et al. Ann Clin Transl Neurol. 2018 Nov 10;6(1):15-26. doi: 10.1002/acn3.660. eCollection 2019 Jan. Ann Clin Transl Neurol. 2018. PMID: 30656180 Free PMC article. Clinical Trial.
The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia patients (NCT02255435). METHODS: Sixty-nine Friedreich ataxia patients were randomized 3:1 to either omave …
The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreic …
Omaveloxolone: a groundbreaking milestone as the first FDA-approved drug for Friedreich ataxia.
Pilotto F, Chellapandi DM, Puccio H. Pilotto F, et al. Trends Mol Med. 2024 Feb;30(2):117-125. doi: 10.1016/j.molmed.2023.12.002. Epub 2024 Jan 24. Trends Mol Med. 2024. PMID: 38272714 Review.
Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disease (NDD) characterized primarily by progressive sensory and spinocerebellar ataxia associated with hypertrophic cardiomyopathy. ...
Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disease (NDD) characterized primarily by progress …
Friedreich Ataxia.
Subramony SH, Lynch DR. Subramony SH, et al. Pediatr Neurol. 2026 Jan;174:148-154. doi: 10.1016/j.pediatrneurol.2025.10.020. Epub 2025 Nov 1. Pediatr Neurol. 2026. PMID: 41252802 Review.
With the introduction of potential new therapy for Friedreich ataxia, the disorder has taken on a new importance in the world of pediatric neurology. ...The recent approval of omaveloxolone makes recognition of Friedreich ataxia and its treatment essen …
With the introduction of potential new therapy for Friedreich ataxia, the disorder has taken on a new importance in the world …
Omaveloxolone for the treatment of Friedreich ataxia: clinical trial results and practical considerations.
Lynch DR, Perlman S, Schadt K. Lynch DR, et al. Expert Rev Neurother. 2024 Mar;24(3):251-258. doi: 10.1080/14737175.2024.2310617. Epub 2024 Jan 30. Expert Rev Neurother. 2024. PMID: 38269532 Review.
INTRODUCTION: Omavaloxolone, an NRF2 activator, recently became the first drug approved specifically for the treatment of Friedreich ataxia (FRDA). This landmark achievement provides a background for a review of the detailed data leading to the approval. ...
INTRODUCTION: Omavaloxolone, an NRF2 activator, recently became the first drug approved specifically for the treatment of Friedreich …
Friedreich ataxia.
Pandolfo M. Pandolfo M. Arch Neurol. 2008 Oct;65(10):1296-303. doi: 10.1001/archneur.65.10.1296. Arch Neurol. 2008. PMID: 18852343 Review.
Friedreich ataxia is an autosomal recessive degenerative disease that primarily affects the nervous system and the heart. ...At the same time, the complex pathogenesis of Friedreich ataxia started to be unraveled. Herein, I review our current knowledge …
Friedreich ataxia is an autosomal recessive degenerative disease that primarily affects the nervous system and the heart. ...A …
Friedreich ataxia.
Johnson WG. Johnson WG. Clin Neurosci. 1995;3(1):33-8. Clin Neurosci. 1995. PMID: 7614092 Review.
Using linkage mapping techniques, the classical form of Friedreich ataxia has been localized to 9q13-q21, a region on the long arm of chromosome 9. ...It is likely that the Freidreich ataxia gene will be cloned soon. A condition resembling Friedreich ataxi …
Using linkage mapping techniques, the classical form of Friedreich ataxia has been localized to 9q13-q21, a region on the long …
Propensity matched comparison of omaveloxolone treatment to Friedreich ataxia natural history data.
Lynch DR, Goldsberry A, Rummey C, Farmer J, Boesch S, Delatycki MB, Giunti P, Hoyle JC, Mariotti C, Mathews KD, Nachbauer W, Perlman S, Subramony SH, Wilmot G, Zesiewicz T, Weissfeld L, Meyer C. Lynch DR, et al. Ann Clin Transl Neurol. 2024 Jan;11(1):4-16. doi: 10.1002/acn3.51897. Epub 2023 Sep 10. Ann Clin Transl Neurol. 2024. PMID: 37691319 Free PMC article.
OBJECTIVE: The natural history of Friedreich ataxia is being investigated in a multi-center longitudinal study designated the Friedreich ataxia Clinical Outcome Measures Study (FACOMS). ...INTERPRETATION: These results suggest a meaningful slowing of …
OBJECTIVE: The natural history of Friedreich ataxia is being investigated in a multi-center longitudinal study designated the …
Friedreich's ataxia: new insights.
Krasilnikova MM, Humphries CL, Shinsky EM. Krasilnikova MM, et al. Emerg Top Life Sci. 2023 Dec 14;7(3):313-323. doi: 10.1042/ETLS20230017. Emerg Top Life Sci. 2023. PMID: 37698160 Review.
Friedreich ataxia (FRDA) is an inherited disease that is typically caused by GAA repeat expansion within the first intron of the FXN gene coding for frataxin. ...
Friedreich ataxia (FRDA) is an inherited disease that is typically caused by GAA repeat expansion within the first intron of t …
Skeletal Muscle Involvement in Friedreich Ataxia.
Indelicato E, Wanschitz J, Löscher W, Boesch S. Indelicato E, et al. Int J Mol Sci. 2024 Sep 13;25(18):9915. doi: 10.3390/ijms25189915. Int J Mol Sci. 2024. PMID: 39337401 Free PMC article. Review.
Friedreich Ataxia (FRDA) is an inherited neuromuscular disorder triggered by a deficit of the mitochondrial protein frataxin. ...
Friedreich Ataxia (FRDA) is an inherited neuromuscular disorder triggered by a deficit of the mitochondrial protein frataxin. …
716 results