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Serum Iron Status and Retinal Degenerative Diseases: A Mendelian Randomization Study on AMD, RP, and DR.
Qu S, Zhu Y, Pfeiffer N, Grus FH. Qu S, et al. Among authors: grus fh. Nutrients. 2024 Oct 31;16(21):3747. doi: 10.3390/nu16213747. Nutrients. 2024. PMID: 39519580 Free PMC article.
Transferrin was positively associated with the odds of AMD (whether dry or wet) (OR = 1.167, 95% CI = 1.045-1.304, p = 0.006) and wet AMD (OR = 1.194, 95% CI = 1.018-1.402, p = 0.030). Ferritin was negatively associated with the odds of wet AMD (OR = 0.555, 9 …
Transferrin was positively associated with the odds of AMD (whether dry or wet) (OR = 1.167, 95% CI = 1.045-1.304, p = 0.006) and wet …
Serum Autoantibodies in Patients with Dry and Wet Age-Related Macular Degeneration.
Korb CA, Beck S, Wolters D, Lorenz K, Pfeiffer N, Grus FH. Korb CA, et al. Among authors: grus fh. J Clin Med. 2023 Feb 17;12(4):1590. doi: 10.3390/jcm12041590. J Clin Med. 2023. PMID: 36836125 Free PMC article.
MATERIALS AND METHODS: IgG Immunoreactivities were compared in patients suffering from dry age-related macular degeneration (AMD) (n = 20), patients with treatment-naive exudative AMD (n = 29) and healthy volunteers (n = 21). ...Some immunoreacitvities were antithet …
MATERIALS AND METHODS: IgG Immunoreactivities were compared in patients suffering from dry age-related macular degeneration (AMD) (n …
Age-Related Macular Degeneration and Mitochondria-Associated Autoantibodies: A Review of the Specific Pathogenesis and Therapeutic Strategies.
Qu S, Lin H, Pfeiffer N, Grus FH. Qu S, et al. Among authors: grus fh. Int J Mol Sci. 2024 Jan 28;25(3):1624. doi: 10.3390/ijms25031624. Int J Mol Sci. 2024. PMID: 38338904 Free PMC article. Review.
Age-related macular degeneration (AMD) is a severe retinal disease that causes irreversible visual loss and blindness in elderly populations worldwide. The pathological mechanism of AMD is complex, involving the interactions of multiple environmental and genetic fac …
Age-related macular degeneration (AMD) is a severe retinal disease that causes irreversible visual loss and blindness in elderly popu …
Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS).
Korb CA, Lackner KJ, Wolters D, Schuster AK, Nickels S, Beutgen VM, Münzel T, Wild PS, Beutel ME, Schmidtmann I, Pfeiffer N, Grus FH. Korb CA, et al. Among authors: grus fh. Graefes Arch Clin Exp Ophthalmol. 2023 Oct;261(10):2763-2773. doi: 10.1007/s00417-023-06085-2. Epub 2023 May 9. Graefes Arch Clin Exp Ophthalmol. 2023. PMID: 37160502 Free PMC article.
PURPOSE: Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, ob …
PURPOSE: Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this …
Correlation of Functional and Structural Outcomes with Serum Antibody Profiles in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Healthy Subjects: A Prospective, Controlled Monocenter Trial.
Korb CA, Gerstenberger E, Lorenz K, Bell K, Beck A, Scheller Y, Beutgen VM, Wolters D, Grus FH. Korb CA, et al. Among authors: grus fh. J Clin Med. 2024 Nov 21;13(23):7033. doi: 10.3390/jcm13237033. J Clin Med. 2024. PMID: 39685491 Free PMC article.
Background: Age-related macular degeneration (AMD) is a multifactorial disorder, and there is growing evidence of immunological involvement in its pathogenesis. ...Fifty subjects with neovascular AMD and twenty healthy volunteers were enrolled. The primary objective …
Background: Age-related macular degeneration (AMD) is a multifactorial disorder, and there is growing evidence of immunological invol …
Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration.
Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH. Joachim SC, et al. Among authors: grus fh. Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):619-26. doi: 10.1007/s00417-006-0429-9. Epub 2006 Oct 13. Graefes Arch Clin Exp Ophthalmol. 2007. PMID: 17058093
The discriminant analysis revealed a statistical significant difference between the antibody profiles of the AMD and the CO group (P=0.000023). Not only up-regulations of antigen-antibody-reactivities in the AMD group at some molecular weight ranges, e.g. at 46 and …
The discriminant analysis revealed a statistical significant difference between the antibody profiles of the AMD and the CO group (P= …