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Analyses of Brucella pathogenesis, host immunity, and vaccine targets using systems biology and bioinformatics.
He Y. He Y. Front Cell Infect Microbiol. 2012 Feb 1;2:2. doi: 10.3389/fcimb.2012.00002. eCollection 2012. Front Cell Infect Microbiol. 2012. PMID: 22919594 Free PMC article. Review.
Based on more than 30 sequenced Brucella genomes, comparative genomics is able to identify gene variations among Brucella strains that help to explain host specificity and virulence differences among Brucella species. ...The Vaxign reverse vaccinology has bee …
Based on more than 30 sequenced Brucella genomes, comparative genomics is able to identify gene variations among Brucella stra …
Literature Mining and Ontology based Analysis of Host-Brucella Gene-Gene Interaction Network.
Karadeniz İ, Hur J, He Y, Özgür A. Karadeniz İ, et al. Among authors: he y. Front Microbiol. 2015 Dec 9;6:1386. doi: 10.3389/fmicb.2015.01386. eCollection 2015. Front Microbiol. 2015. PMID: 26696993 Free PMC article.
Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-Brucella interaction is crucial to understand host immunity against Brucella infection and Brucella pathogenesis against ho …
Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-B …
Ontology-based representation and analysis of host-Brucella interactions.
Lin Y, Xiang Z, He Y. Lin Y, et al. Among authors: he y. J Biomed Semantics. 2015 Oct 5;6:37. doi: 10.1186/s13326-015-0036-y. eCollection 2015. J Biomed Semantics. 2015. PMID: 26445639 Free PMC article.
RESULTS: Different levels of host-Brucella interactions based on different host cell types and Brucella strains were first defined ontologically. ...Two Brucella pathogenesis mechanisms were ontologically represented: Brucella Type IV secretion system …
RESULTS: Different levels of host-Brucella interactions based on different host cell types and Brucella strains were first def …
Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network.
Hur J, Xiang Z, Feldman EL, He Y. Hur J, et al. Among authors: he y. BMC Immunol. 2011 Aug 26;12:49. doi: 10.1186/1471-2172-12-49. BMC Immunol. 2011. PMID: 21871085 Free PMC article.
RESULTS: The VO-based SciMiner (VO-SciMiner) was developed to incorporate a total of 67 Brucella vaccine terms. A set of rules for term expansion of VO terms were learned from training data, consisting of 90 biomedical articles related to Brucella vaccine terms. ... …
RESULTS: The VO-based SciMiner (VO-SciMiner) was developed to incorporate a total of 67 Brucella vaccine terms. A set of rules for te …
BBP: Brucella genome annotation with literature mining and curation.
Xiang Z, Zheng W, He Y. Xiang Z, et al. Among authors: he y. BMC Bioinformatics. 2006 Jul 16;7:347. doi: 10.1186/1471-2105-7-347. BMC Bioinformatics. 2006. PMID: 16842628 Free PMC article.
Sequences of four Brucella genomes have been published, and various Brucella gene and genome data and analysis resources exist. ...Brucella gene mutations and genetic interactions are annotated using Limix leading to better understanding of Brucella pa …
Sequences of four Brucella genomes have been published, and various Brucella gene and genome data and analysis resources exist …
Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.
He Y, Xiang Z. He Y, et al. Immunome Res. 2010 Sep 27;6 Suppl 1(Suppl 1):S5. doi: 10.1186/1745-7580-6-S1-S5. Immunome Res. 2010. PMID: 20875156 Free PMC article.
As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective Brucella antigens, and 68 host response studies to Brucella vaccines from 97 peer-reviewed articles. ...CONCLUSIONS: Bioinform …
As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective …
Molecular targets for rapid identification of Brucella spp.
Ratushna VG, Sturgill DM, Ramamoorthy S, Reichow SA, He Y, Lathigra R, Sriranganathan N, Halling SM, Boyle SM, Gibas CJ. Ratushna VG, et al. Among authors: he y. BMC Microbiol. 2006 Feb 22;6:13. doi: 10.1186/1471-2180-6-13. BMC Microbiol. 2006. PMID: 16504063 Free PMC article.
BACKGROUND: Brucella is an intracellular pathogen capable of infecting animals and humans. There are six recognized species of Brucella that differ in their host preference. The genomes of the three Brucella species have been recently sequenced. ...
BACKGROUND: Brucella is an intracellular pathogen capable of infecting animals and humans. There are six recognized species of Bru …
Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus.
Chen F, He Y. Chen F, et al. Among authors: he y. PLoS One. 2009 Aug 28;4(8):e6830. doi: 10.1371/journal.pone.0006830. PLoS One. 2009. PMID: 19714247 Free PMC article.
Brucella species are Gram-negative, facultative intracellular bacteria that cause zoonotic brucellosis. ...The biological relevance of Brucella O antigen and caspase-2-mediated macrophage cell death in Brucella pathogenesis and protective Brucella immu …
Brucella species are Gram-negative, facultative intracellular bacteria that cause zoonotic brucellosis. ...The biological relevance o …
29 results