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Analyses of Brucella pathogenesis, host immunity, and vaccine targets using systems biology and bioinformatics.
He Y. He Y. Front Cell Infect Microbiol. 2012 Feb 1;2:2. doi: 10.3389/fcimb.2012.00002. eCollection 2012. Front Cell Infect Microbiol. 2012. PMID: 22919594 Free PMC article. Review.
Based on more than 30 sequenced Brucella genomes, comparative genomics is able to identify gene variations among Brucella strains that help to explain host specificity and virulence differences among Brucella species. ...The Vaxign reverse vaccinology has bee …
Based on more than 30 sequenced Brucella genomes, comparative genomics is able to identify gene variations among Brucella stra …
Ontology-based representation and analysis of host-Brucella interactions.
Lin Y, Xiang Z, He Y. Lin Y, et al. Among authors: he y. J Biomed Semantics. 2015 Oct 5;6:37. doi: 10.1186/s13326-015-0036-y. eCollection 2015. J Biomed Semantics. 2015. PMID: 26445639 Free PMC article.
RESULTS: Different levels of host-Brucella interactions based on different host cell types and Brucella strains were first defined ontologically. ...Two Brucella pathogenesis mechanisms were ontologically represented: Brucella Type IV secretion system …
RESULTS: Different levels of host-Brucella interactions based on different host cell types and Brucella strains were first def …
Literature Mining and Ontology based Analysis of Host-Brucella Gene-Gene Interaction Network.
Karadeniz İ, Hur J, He Y, Özgür A. Karadeniz İ, et al. Among authors: he y. Front Microbiol. 2015 Dec 9;6:1386. doi: 10.3389/fmicb.2015.01386. eCollection 2015. Front Microbiol. 2015. PMID: 26696993 Free PMC article.
Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-Brucella interaction is crucial to understand host immunity against Brucella infection and Brucella pathogenesis against ho …
Brucella is an intracellular bacterium that causes chronic brucellosis in humans and various mammals. The identification of host-B …
BBP: Brucella genome annotation with literature mining and curation.
Xiang Z, Zheng W, He Y. Xiang Z, et al. Among authors: he y. BMC Bioinformatics. 2006 Jul 16;7:347. doi: 10.1186/1471-2105-7-347. BMC Bioinformatics. 2006. PMID: 16842628 Free PMC article.
Sequences of four Brucella genomes have been published, and various Brucella gene and genome data and analysis resources exist. ...Brucella gene mutations and genetic interactions are annotated using Limix leading to better understanding of Brucella pa …
Sequences of four Brucella genomes have been published, and various Brucella gene and genome data and analysis resources exist …
Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network.
Hur J, Xiang Z, Feldman EL, He Y. Hur J, et al. Among authors: he y. BMC Immunol. 2011 Aug 26;12:49. doi: 10.1186/1471-2172-12-49. BMC Immunol. 2011. PMID: 21871085 Free PMC article.
RESULTS: The VO-based SciMiner (VO-SciMiner) was developed to incorporate a total of 67 Brucella vaccine terms. A set of rules for term expansion of VO terms were learned from training data, consisting of 90 biomedical articles related to Brucella vaccine terms. ... …
RESULTS: The VO-based SciMiner (VO-SciMiner) was developed to incorporate a total of 67 Brucella vaccine terms. A set of rules for te …
Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.
He Y, Xiang Z. He Y, et al. Immunome Res. 2010 Sep 27;6 Suppl 1(Suppl 1):S5. doi: 10.1186/1745-7580-6-S1-S5. Immunome Res. 2010. PMID: 20875156 Free PMC article.
As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective Brucella antigens, and 68 host response studies to Brucella vaccines from 97 peer-reviewed articles. ...CONCLUSIONS: Bioinform …
As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective …
Comparative genomic analysis between newly sequenced Brucella suis Vaccine Strain S2 and the Virulent Brucella suis Strain 1330.
Di DD, Jiang H, Tian LL, Kang JL, Zhang W, Yi XP, Ye F, Zhong Q, Ni B, He YY, Xia L, Yu Y, Cui BY, Mao X, Fan WX. Di DD, et al. Among authors: he yy. BMC Genomics. 2016 Sep 20;17(1):741. doi: 10.1186/s12864-016-3076-5. BMC Genomics. 2016. PMID: 27645563 Free PMC article.
BACKGROUND: Brucellosis is a bacterial disease caused by Brucella infection. In the late fifties, Brucella suis vaccine strain S2 with reduced virulence was obtained by serial transfer of a virulent B. suis biovar 1 strain in China. ...CONCLUSIONS: The data presente …
BACKGROUND: Brucellosis is a bacterial disease caused by Brucella infection. In the late fifties, Brucella suis vaccine strain …
Comparative transcriptome analysis of Brucella melitensis in an acidic environment: Identification of the two-component response regulator involved in the acid resistance and virulence of Brucella.
Liu Q, Liu X, Yan F, He Y, Wei J, Zhang Y, Liu L, Sun Y. Liu Q, et al. Among authors: he y. Microb Pathog. 2016 Feb;91:92-8. doi: 10.1016/j.micpath.2015.11.007. Epub 2015 Dec 12. Microb Pathog. 2016. PMID: 26691825
Brucella melitensis, encounters a very stressful environment in phagosomes, especially low pH levels. ...Six pathways (oxidative phosphorylation, iron-transporting, bacterial secretion system, transcriptional regulation, two-component system, and ABC transporters pathways) …
Brucella melitensis, encounters a very stressful environment in phagosomes, especially low pH levels. ...Six pathways (oxidative phos …
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