Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 1
2003 2
2004 1
2005 1
2006 1
2007 1
2011 2
2012 2
2013 1
2015 2
2018 2
2019 2
2021 5
2023 5
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Results by year

Filters applied: . Clear all
Page 1
Long-term progression of clinician-reported and gait performance outcomes in hereditary spastic paraplegias.
Cubillos Arcila DM, Dariva Machado G, Martins VF, Leotti VB, Schüle R, Peyré-Tartaruga LA, Saute JAM. Cubillos Arcila DM, et al. Front Neurosci. 2023 Sep 22;17:1226479. doi: 10.3389/fnins.2023.1226479. eCollection 2023. Front Neurosci. 2023. PMID: 37811319 Free PMC article.
INTRODUCTION: Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurodegenerative diseases in which little is known about the most appropriate clinical outcome assessments (COAs) to capture disease progression. ...METHODS: Twenty-six HSP pati …
INTRODUCTION: Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurodegenerative diseases in which little is …
Dalfampridine as a promising agent in the management of hereditary spastic paraplegia: A triple-blinded, randomized, placebo-controlled pilot trial.
Selcuk Muhtaroglu F, Belgen Kaygisiz B, Usar Incirli S, Kahraman T. Selcuk Muhtaroglu F, et al. J Clin Neurosci. 2023 Nov;117:136-142. doi: 10.1016/j.jocn.2023.09.026. Epub 2023 Oct 5. J Clin Neurosci. 2023. PMID: 37804674 Clinical Trial.
Limited but encouraging results support the use of dalfampridine in patients with hereditary spastic paraplegia (HSP). Our aim was to investigate the effects of dalfampridine on walking speed, muscle length, spasticity, functional strength, and functional mob …
Limited but encouraging results support the use of dalfampridine in patients with hereditary spastic paraplegia (HSP). …
Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies.
Chen X, Dong T, Hu Y, De Pace R, Mattera R, Eberhardt K, Ziegler M, Pirovolakis T, Sahin M, Bonifacino JS, Ebrahimi-Fakhari D, Gray SJ. Chen X, et al. J Clin Invest. 2023 May 15;133(10):e164575. doi: 10.1172/JCI164575. J Clin Invest. 2023. PMID: 36951961 Free PMC article.
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function variants in the AP4M1 gene. ...-administered AAV9/AP4M1, supporting an investigational gene transfer clinical trial to treat SPG50.
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function varia
Gait-Adaptability Training in People With Hereditary Spastic Paraplegia: A Randomized Clinical Trial.
van de Venis L, van de Warrenburg B, Weerdesteyn V, Geurts ACH, Nonnekes J. van de Venis L, et al. Neurorehabil Neural Repair. 2023 Jan;37(1):27-36. doi: 10.1177/15459683221147839. Epub 2023 Jan 25. Neurorehabil Neural Repair. 2023. PMID: 36695288 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVES: In people with hereditary spastic paraplegia (HSP), reduced gait adaptability is common and disabling. ...The aim of this study was to assess the efficacy of a 5-week gait-adaptability training in people with pure HSP. METHOD: We co …
BACKGROUND AND OBJECTIVES: In people with hereditary spastic paraplegia (HSP), reduced gait adaptability is common and …
A Randomized Controlled Trial of the Effect of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex on Lower Extremity Spasticity in Hereditary Spastic Paraplegia.
Bastani PB, Kordjazi M, Oveisgharan S, Abdi S. Bastani PB, et al. J Clin Neurophysiol. 2023 Feb 1;40(2):173-179. doi: 10.1097/WNP.0000000000000874. Epub 2021 Nov 23. J Clin Neurophysiol. 2023. PMID: 34817445 Clinical Trial.
INTRODUCTION: Hereditary spastic paraplegia refers to a group of conditions characterized by a slow progression of spasticity in lower limbs resulting in gait abnormalities. ...CONCLUSIONS: Repetitive transcranial magnetic stimulation is an effective method i …
INTRODUCTION: Hereditary spastic paraplegia refers to a group of conditions characterized by a slow progression of spas …
Potential markers for sample size estimations in hereditary spastic paraplegia type 5.
Lin Q, Liu Y, Ye Z, Hu J, Cai W, Weng Q, Chen WJ, Wang N, Cao D, Lin Y, Fu Y. Lin Q, et al. Orphanet J Rare Dis. 2021 Sep 19;16(1):391. doi: 10.1186/s13023-021-02014-w. Orphanet J Rare Dis. 2021. PMID: 34538260 Free PMC article.
BACKGROUND: Aim to identify potential biomarkers to assess therapeutic efficacy for hereditary spastic paraplegias type 5 (SPG5) by investigating the clinical, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) features. ...Our finding supports th …
BACKGROUND: Aim to identify potential biomarkers to assess therapeutic efficacy for hereditary spastic paraplegias type 5 (SPG …
Recent advances in understanding hereditary spastic paraplegias and emerging therapies.
Lallemant-Dudek P, Darios F, Durr A. Lallemant-Dudek P, et al. Fac Rev. 2021 Mar 10;10:27. doi: 10.12703/r/10-27. eCollection 2021. Fac Rev. 2021. PMID: 33817696 Free PMC article. Review.
Hereditary spastic paraplegias (HSPs) are a group of rare, inherited, neurological diseases characterized by broad clinical and genetic heterogeneity. ...There are no specific therapies against HSPs, and there is a dearth of randomized trials in patien
Hereditary spastic paraplegias (HSPs) are a group of rare, inherited, neurological diseases characterized by broad clinical
Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial.
Zeigelboim BS, José MR, Santos GJBD, Severiano MIR, Teive HAG, Stechman-Neto J, Santos RS, de Araújo CM, Cavalcante-Leão BL. Zeigelboim BS, et al. PLoS One. 2021 Apr 1;16(4):e0249095. doi: 10.1371/journal.pone.0249095. eCollection 2021. PLoS One. 2021. PMID: 33793609 Free PMC article. Clinical Trial.
Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic paraplegia is a heterogeneous group of hereditary degenerative diseases involving the disorder of a single gene and is character …
Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic
Improving gait adaptability in patients with hereditary spastic paraplegia (Move-HSP): study protocol for a randomized controlled trial.
van de Venis L, van de Warrenburg BPC, Weerdesteyn V, van Lith BJH, Geurts ACH, Nonnekes J. van de Venis L, et al. Trials. 2021 Jan 7;22(1):32. doi: 10.1186/s13063-020-04932-9. Trials. 2021. PMID: 33413555 Free PMC article.
BACKGROUND: People with hereditary spastic paraplegia (HSP) experience difficulties adapting their gait to meet environmental demands, a skill required for safe and independent ambulation. ...In addition, this study aims to identify key determinants of C-Mill …
BACKGROUND: People with hereditary spastic paraplegia (HSP) experience difficulties adapting their gait to meet environ …
The Effect of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Hereditary Spastic Paraplegia.
Antczak J, Pera J, Dąbroś M, Koźmiński W, Czyżycki M, Wężyk K, Dwojak M, Banach M, Slowik A. Antczak J, et al. Neural Plast. 2019 May 12;2019:7638675. doi: 10.1155/2019/7638675. eCollection 2019. Neural Plast. 2019. PMID: 31214256 Free PMC article. Clinical Trial.
BACKGROUND: Hereditary spastic paraplegia (HSP) is a heterogeneous group of inherited disorders affecting predominantly the motor cortex and pyramidal tract, which results in slowly progressing gait disorders, as well as spasticity and weakness of lower extre …
BACKGROUND: Hereditary spastic paraplegia (HSP) is a heterogeneous group of inherited disorders affecting predominantly …
26 results