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1993 2
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511 results
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Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease via promoting mitophagy.
Hu ZL, Sun T, Lu M, Ding JH, Du RH, Hu G. Hu ZL, et al. Brain Behav Immun. 2019 Oct;81:509-522. doi: 10.1016/j.bbi.2019.07.009. Epub 2019 Jul 6. Brain Behav Immun. 2019. PMID: 31288070 Free article.
However, the precise role of astrocytic Kir6.1-contaning K-ATP channel (Kir6.1/K-ATP) in PD is not well characterized. In this study, astrocytic Kir6.1 knockout (KO) mice were used to examine the effect of astrocytic Kir6.1/ …
However, the precise role of astrocytic Kir6.1-contaning K-ATP channel (Kir6.1/K-ATP) in PD is not well characte …
SUR2B/Kir6.1 channel openers correct endothelial dysfunction in chronic heart failure via the miR-1-3p/ET-1 pathway.
Wang S, Guo X, Long CL, Li C, Zhang YF, Wang J, Wang H. Wang S, et al. Biomed Pharmacother. 2019 Feb;110:431-439. doi: 10.1016/j.biopha.2018.11.135. Epub 2018 Dec 5. Biomed Pharmacother. 2019. PMID: 30530045 Free article.
Therefore, we verified that SUR2B/Kir6.1 channel openers could correct endothelial imbalance and ameliorate chronic heart failure through the miR-1-3p/ET-1 pathway in endothelial cells. Our study provides comprehensive insights into the molecular mecha …
Therefore, we verified that SUR2B/Kir6.1 channel openers could correct endothelial imbalance and ameliorate chronic heart fail …
Astrocyte-specific deletion of Kir6.1/K-ATP channel aggravates cerebral ischemia/reperfusion injury through endoplasmic reticulum stress in mice.
Zhong CJ, Chen MM, Lu M, Ding JH, Du RH, Hu G. Zhong CJ, et al. Exp Neurol. 2019 Jan;311:225-233. doi: 10.1016/j.expneurol.2018.10.005. Epub 2018 Oct 10. Exp Neurol. 2019. PMID: 30315808
However, the exact role of astrocytic Kir6.1-containg K-ATP channel (Kir6.1/K-ATP) in ischemic stroke remains unclear. ...Finally, inhibition of ER stress rescued astrocyte apoptosis induced by Kir6.1 deletion during I/R injury. Collectiv …
However, the exact role of astrocytic Kir6.1-containg K-ATP channel (Kir6.1/K-ATP) in ischemic stroke remains un …
Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease.
Du RH, Sun HB, Hu ZL, Lu M, Ding JH, Hu G. Du RH, et al. Cell Death Dis. 2018 Mar 14;9(3):404. doi: 10.1038/s41419-018-0437-9. Cell Death Dis. 2018. PMID: 29540778 Free PMC article.
Kir6.1 knockdown inhibited M2 polarization and simultaneously exaggerated M1 microglial inflammatory responses, while Kir6.1 overexpression promoted M2 polarization and synchronously alleviated the toxic phase of M1 microglia polarization. ...Collectiv
Kir6.1 knockdown inhibited M2 polarization and simultaneously exaggerated M1 microglial inflammatory responses, while Kir6
Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion.
Emanuele E, Falcone C, Carabela M, Minoretti P, D'Angelo A, Montagna L, Geroldi D. Emanuele E, et al. Int J Mol Med. 2003 Oct;12(4):509-12. Int J Mol Med. 2003. PMID: 12964027
No mutations were detected in the sample analyzed, thus suggesting that Kir6.1/KCNJ8 aberrations are not a common cause of abnormal coronary vasomotion in Italians. To the best of our knowledge, this study represents the first mutational analysis of Kir6
No mutations were detected in the sample analyzed, thus suggesting that Kir6.1/KCNJ8 aberrations are not a common cause …
Kir6.1 Heterozygous Mice Exhibit Aberrant Amygdala-Dependent Cued Fear Memory.
Inagaki R, Moriguchi S, Fukunaga K. Inagaki R, et al. Mol Neurobiol. 2020 Mar;57(3):1622-1635. doi: 10.1007/s12035-019-01840-1. Epub 2019 Dec 6. Mol Neurobiol. 2020. PMID: 31808063
In the present study, the protein and mRNA expression levels of Kir6.1, but not Kir6.2, were decreased in the lateral amygdala (LA) of CORT mice. Heterozygous Kir6.1-null (Kir6.1(+/-)) mice also showed enhanced tone (cued) fear mem …
In the present study, the protein and mRNA expression levels of Kir6.1, but not Kir6.2, were decreased in the lateral a …
ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.
Tinker A, Aziz Q, Li Y, Specterman M. Tinker A, et al. Compr Physiol. 2018 Sep 14;8(4):1463-1511. doi: 10.1002/cphy.c170048. Compr Physiol. 2018. PMID: 30215858 Review.
They have a rich and diverse pharmacology with a number of agents acting as specific inhibitors and activators. K(ATP) channels are formed of pore-forming subunits, Kir6.1 and Kir6.2, and a large auxiliary subunit, the sulfonylurea receptor (SUR1, SUR2A, and …
They have a rich and diverse pharmacology with a number of agents acting as specific inhibitors and activators. K(ATP) channels are formed o …
Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia.
Kane GC, Lam CF, O'Cochlain F, Hodgson DM, Reyes S, Liu XK, Miki T, Seino S, Katusic ZS, Terzic A. Kane GC, et al. FASEB J. 2006 Nov;20(13):2271-80. doi: 10.1096/fj.06-6349com. FASEB J. 2006. PMID: 17077304
Here, in a model of acute septic shock induced by endotoxin challenge with Escherichia coli lipopolysaccharide (LPS), knockout of the KCNJ8 gene encoding the vascular Kir6.1 K(ATP) channel pore predisposed to an early and profound survival disadvantage. ...Ap …
Here, in a model of acute septic shock induced by endotoxin challenge with Escherichia coli lipopolysaccharide (LPS), knockout of the KCN
Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome.
Tester DJ, Tan BH, Medeiros-Domingo A, Song C, Makielski JC, Ackerman MJ. Tester DJ, et al. Circ Cardiovasc Genet. 2011 Oct;4(5):510-5. doi: 10.1161/CIRCGENETICS.111.960195. Epub 2011 Aug 11. Circ Cardiovasc Genet. 2011. PMID: 21836131 Free PMC article.
BACKGROUND: Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6.1 (K(ATP)) channel critically regulates vascular tone and cardiac adaptive response to systemic metabolic stressors, including s …
BACKGROUND: Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6
Is Kir6.1 a subunit of mitoK(ATP)?
Foster DB, Rucker JJ, Marbán E. Foster DB, et al. Biochem Biophys Res Commun. 2008 Feb 15;366(3):649-56. doi: 10.1016/j.bbrc.2007.11.154. Epub 2007 Dec 7. Biochem Biophys Res Commun. 2008. PMID: 18068667 Free PMC article.
To ascertain the molecular identity of mitoK(ATP) we therefore sought to purify this putative mitochondrial Kir6.1, and conclusively identify the subunits by mass spectrometry. ...The data suggest it is premature to assign Kir6.1 a role in mitoK(ATP) o …
To ascertain the molecular identity of mitoK(ATP) we therefore sought to purify this putative mitochondrial Kir6.1, and conclu …
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