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2002 2
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Page 1
Livestock Challenge Models of Rift Valley Fever for Agricultural Vaccine Testing.
Kroeker AL, Babiuk S, Pickering BS, Richt JA, Wilson WC. Kroeker AL, et al. Front Vet Sci. 2020 May 27;7:238. doi: 10.3389/fvets.2020.00238. eCollection 2020. Front Vet Sci. 2020. PMID: 32528981 Free PMC article. Review.
Since the discovery of Rift Valley Fever virus (RVFV) in Kenya in 1930, the virus has become widespread throughout most of Africa and is characterized by sporadic outbreaks. ...Furthermore, considerable efforts to establish reliable challenge models of Rift Valley f …
Since the discovery of Rift Valley Fever virus (RVFV) in Kenya in 1930, the virus has become widespread throughout most of Afr …
Increased Susceptibility of Cattle to Intranasal RVFV Infection.
Kroeker AL, Smid V, Embury-Hyatt C, Collignon B, Pinette M, Babiuk S, Pickering B. Kroeker AL, et al. Front Vet Sci. 2020 Apr 29;7:137. doi: 10.3389/fvets.2020.00137. eCollection 2020. Front Vet Sci. 2020. PMID: 32411730 Free PMC article.
Rift Valley Fever virus (RVFV) is a zoonotic mosquito-borne virus that belongs to the Phenuiviridae family. Infections in animal herds cause abortion storms, high mortality rates in neonates, and mild to severe symptoms. Infected animals can also transmit the vir
Rift Valley Fever virus (RVFV) is a zoonotic mosquito-borne virus that belongs to the Phenuiviridae family. Infections in anim …
Development and Characterization of a Guinea Pig-Adapted Sudan Virus.
Wong G, He S, Wei H, Kroeker A, Audet J, Leung A, Cutts T, Graham J, Kobasa D, Embury-Hyatt C, Kobinger GP, Qiu X. Wong G, et al. Among authors: kroeker a. J Virol. 2015 Oct 21;90(1):392-9. doi: 10.1128/JVI.02331-15. Print 2016 Jan 1. J Virol. 2015. PMID: 26491156 Free PMC article.
Infections with Sudan virus (SUDV), a member of the genus Ebolavirus, result in a severe hemorrhagic fever with a fatal outcome in over 50% of human cases. ...These developments will accelerate the development of specific medical countermeasures in preparation for a future …
Infections with Sudan virus (SUDV), a member of the genus Ebolavirus, result in a severe hemorrhagic fever with a fatal outcome in ov …
RVFV Infection in Goats by Different Routes of Inoculation.
Kroeker AL, Smid V, Embury-Hyatt C, Moffat E, Collignon B, Lung O, Lindsay R, Weingartl H. Kroeker AL, et al. Viruses. 2018 Dec 12;10(12):709. doi: 10.3390/v10120709. Viruses. 2018. PMID: 30545088 Free PMC article.
Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. ...We evaluated two goat breeds (Nubian and LaMancha), three routes of inoculation (intranasal, mosquito-primed subcutaneous, and subcutaneous) using an infectious dose of 107 pfu/mL, a …
Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. ...We evaluated two goat breeds (Nubian and LaMan …
Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs.
Senthilkumaran C, Kroeker AL, Smith G, Embury-Hyatt C, Collignon B, Ramirez-Medina E, Azzinaro PA, Pickering BS, Diaz-San Segundo F, Weingartl HM, de Los Santos T. Senthilkumaran C, et al. Among authors: kroeker al. Pathogens. 2022 Apr 8;11(4):449. doi: 10.3390/pathogens11040449. Pathogens. 2022. PMID: 35456124 Free PMC article.
Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. ...Our results show that pigs pre-treated with Ad5-porIFNalpha did not develop measurable clinical signs, did not s …
Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non …
Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.
Kozak R, He S, Kroeker A, de La Vega MA, Audet J, Wong G, Urfano C, Antonation K, Embury-Hyatt C, Kobinger GP, Qiu X. Kozak R, et al. Among authors: kroeker a. J Virol. 2016 Sep 29;90(20):9209-23. doi: 10.1128/JVI.01033-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27489269 Free PMC article.
Bundibugyo virus (BDBV) is the etiological agent of a severe hemorrhagic fever in humans with a case-fatality rate ranging from 25 to 36%. ...To address this, we demonstrated that ferrets are susceptible models to BDBV infection as well as to Ebola virus infection a …
Bundibugyo virus (BDBV) is the etiological agent of a severe hemorrhagic fever in humans with a case-fatality rate ranging from 25 to …
Systems biology unravels interferon responses to respiratory virus infections.
Kroeker AL, Coombs KM. Kroeker AL, et al. World J Biol Chem. 2014 Feb 26;5(1):12-25. doi: 10.4331/wjbc.v5.i1.12. World J Biol Chem. 2014. PMID: 24600511 Free PMC article. Review.
Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. ...
Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. Howev …
The Intersection of Age and Influenza Severity: Utility of Ferrets for Dissecting the Age-Dependent Immune Responses and Relevance to Age-Specific Vaccine Development.
Rioux M, Francis ME, Swan CL, Ge A, Kroeker A, Kelvin AA. Rioux M, et al. Among authors: kroeker a. Viruses. 2021 Apr 15;13(4):678. doi: 10.3390/v13040678. Viruses. 2021. PMID: 33920917 Free PMC article. Review.
One of the most significant and well-known factors affecting human disease after infection is host age. Another significant factor is the virus, as strain-specific disease severity is well known. Studying age-related impacts on viral infection and vaccination outcom …
One of the most significant and well-known factors affecting human disease after infection is host age. Another significant factor is the …
Characterization of Sudan Ebolavirus infection in ferrets.
Kroeker A, He S, de La Vega MA, Wong G, Embury-Hyatt C, Qiu X. Kroeker A, et al. Oncotarget. 2017 Jul 11;8(28):46262-46272. doi: 10.18632/oncotarget.17694. Oncotarget. 2017. PMID: 28545034 Free PMC article.
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. ...Therefore, other smaller animal models are a valuable asset. We ha …
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for t …
Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.
Yeganeh B, Ghavami S, Kroeker AL, Mahood TH, Stelmack GL, Klonisch T, Coombs KM, Halayko AJ. Yeganeh B, et al. Among authors: kroeker al. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L270-86. doi: 10.1152/ajplung.00011.2014. Epub 2014 Oct 31. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25361566 Free PMC article.
Subcellular trafficking within host cells plays a critical role in viral life cycles, including influenza A virus (IAV). Thus targeting relevant subcellular compartments holds promise for effective intervention to control the impact of influenza infection. ...Thus w …
Subcellular trafficking within host cells plays a critical role in viral life cycles, including influenza A virus (IAV). Thus …
30 results