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Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila.
Chaudhry N, Sica M, Surabhi S, Hernandez DS, Mesquita A, Selimovic A, Riaz A, Lescat L, Bai H, MacIntosh GC, Jenny A. Chaudhry N, et al. Autophagy. 2022 Oct;18(10):2443-2458. doi: 10.1080/15548627.2022.2038999. Epub 2022 Mar 10. Autophagy. 2022. PMID: 35266854 Free PMC article.
In mammalian cells, loss of the lysosome associated membrane proteins LAMP1 and LAMP2 strongly affects autophagy and cholesterol trafficking. Here we show that the previously uncharacterized Drosophila Lamp1 is a bona fide ortholog of vertebrate LAMP1 and LAMP2. Sur …
In mammalian cells, loss of the lysosome associated membrane proteins LAMP1 and LAMP2 strongly affects autophagy and cholesterol traf …
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes.
Cui K, Li Z. Cui K, et al. Front Endocrinol (Lausanne). 2023 May 8;14:1164112. doi: 10.3389/fendo.2023.1164112. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37223013 Free PMC article.
In addition, we identified GAPDH, ITPR1, EIF2AK3, FOXO3, HSPA5, RB1CC1, LAMP2, GABARAPL2, RAB7A, and WIPI1 genes as the hub ARGs. Next, qRT-PCR analysis revealed that expressions of hub DEARGs were consistent with findings from bioinformatics analysis. EIF2AK3, GABARAPL2, …
In addition, we identified GAPDH, ITPR1, EIF2AK3, FOXO3, HSPA5, RB1CC1, LAMP2, GABARAPL2, RAB7A, and WIPI1 genes as the hub ARGs. Nex …
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM. Filipello F, et al. Acta Neuropathol. 2023 Jun;145(6):749-772. doi: 10.1007/s00401-023-02568-y. Epub 2023 Apr 28. Acta Neuropathol. 2023. PMID: 37115208 Free PMC article.
Alteration in lysosomal gene expression, such as decreased expression of genes implicated in lysosomal acidification (ATP6AP2) and chaperone mediated autophagy (LAMP2), together with reduction in lipid droplets were also observed in post-mortem brain tissues from NHD patie …
Alteration in lysosomal gene expression, such as decreased expression of genes implicated in lysosomal acidification (ATP6AP2) and chaperone …
Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer.
Ding J, Wang C, Sun Y, Guo J, Liu S, Cheng Z. Ding J, et al. Biomolecules. 2023 Feb 9;13(2):339. doi: 10.3390/biom13020339. Biomolecules. 2023. PMID: 36830707 Free PMC article.
Eight autophagy-hub genes (ZFYVE1, AMBRA1, LAMP2, TRAF6, PDPK1, ATG2B, DAPK1 and TP53INP2) were screened for an autophagy-related signature. ...
Eight autophagy-hub genes (ZFYVE1, AMBRA1, LAMP2, TRAF6, PDPK1, ATG2B, DAPK1 and TP53INP2) were screened for an autophagy-related sig …
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Yang Y, Wang Q, Song D, Zen R, Zhang L, Wang Y, Yang H, Zhang D, Jia J, Zhang J, Wang J. Yang Y, et al. J Exp Clin Cancer Res. 2020 Sep 22;39(1):197. doi: 10.1186/s13046-020-01701-z. J Exp Clin Cancer Res. 2020. PMID: 32962728 Free PMC article.
The autophagy-related proteins AMPK, Raptor, mTOR, p62, LC3B, atg7, Rab7, LAMP1, LAMP2, and cathepsin D were detected by Immunoblotting. The antitumor effect of ARCSP was explored in vivo by establishing a transplant tumor model in nude mice. ...
The autophagy-related proteins AMPK, Raptor, mTOR, p62, LC3B, atg7, Rab7, LAMP1, LAMP2, and cathepsin D were detected by Immunoblotti …
Mild form of Danon disease: two case reports.
Yasui T, Nagaoka U, Oya Y, Uruha A, Karashima J, Funai A, Miyamoto K, Matsubara S, Sugaya K, Takahashi K, Inoue M, Okubo M, Sugie K, Nishino I. Yasui T, et al. Neuromuscul Disord. 2021 Nov;31(11):1207-1211. doi: 10.1016/j.nmd.2021.07.017. Epub 2021 Jul 31. Neuromuscul Disord. 2021. PMID: 34702653
Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability.
Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Almacellas E, et al. Autophagy. 2021 Mar;17(3):796-813. doi: 10.1080/15548627.2020.1764727. Epub 2020 Jun 23. Autophagy. 2021. PMID: 32573315 Free PMC article.
Our results establish lysosome-dependent degradation as an essential event to prevent chromosomal instability.Abbreviations: 3D: three-dimensional; APC/C: anaphase-promoting complex; ARL8B: ADP ribosylation factor like GTPase 8B; ATG: autophagy-related; BORC: BLOC-one-related com …
Our results establish lysosome-dependent degradation as an essential event to prevent chromosomal instability.Abbreviations: 3D: three-dimen …
New deletion in LAMP2 causing familial Danon disease. Effect of the X-chromosome inactivation.
Sivitskaya L, Vaikhanskaya T, Danilenko N, Liaudanski A, Davydenko O, Zhelev N. Sivitskaya L, et al. Folia Med (Plovdiv). 2022 Oct 31;64(5):853-862. doi: 10.3897/folmed.64.e66292. Folia Med (Plovdiv). 2022. PMID: 36876541
Danon disease (DD), a rare X-linked genetic illness with a poor prognosis, is caused by a mutation in the lysosome-associated membrane protein 2 gene (LAMP2). Three main clinical features of this pathology are cardiomyopathy, skeletal myopathy, and mental retardation. Most …
Danon disease (DD), a rare X-linked genetic illness with a poor prognosis, is caused by a mutation in the lysosome-associated membrane prote …
76 results