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1993 1
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Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
van Eijk M, Pluim D, Dorlo TPC, Marchetti S, Huitema ADR, Beijnen JH. van Eijk M, et al. Pharmacogenomics J. 2021 Jun;21(3):336-345. doi: 10.1038/s41397-021-00213-z. Epub 2021 Mar 1. Pharmacogenomics J. 2021. PMID: 33649517
The anticancer drug docetaxel exhibits large interpatient pharmacokinetic and pharmacodynamic variability. ...None of the tested CYP3A, ABCB1, ABCC2, and SLCO1B3 genotypes and diplotypes showed a significant relation with an altered bioavailability or clearance of either d …
The anticancer drug docetaxel exhibits large interpatient pharmacokinetic and pharmacodynamic variability. ...None of the tested CYP3 …
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
Ferrara R, Auger N, Auclin E, Besse B. Ferrara R, et al. J Thorac Oncol. 2018 Jan;13(1):27-45. doi: 10.1016/j.jtho.2017.10.021. Epub 2017 Nov 8. J Thorac Oncol. 2018. PMID: 29128428 Free article. Review.
To date, several preclinical models, clinical trials, and retrospective studies have investigated multitarget inhibitors with anti-rearranged during transfection proto-oncogene (RET) activity in patients with RET-rearranged lung cancer. ...Importantly, the absence o …
To date, several preclinical models, clinical trials, and retrospective studies have investigated multitarget inhibitors with anti-re …
Mutation pattern is an influential factor on functional mutation rates in cancer.
Du C, Wu X, Li J. Du C, et al. Cancer Cell Int. 2016 Feb 9;16:2. doi: 10.1186/s12935-016-0278-5. eCollection 2015. Cancer Cell Int. 2016. Retraction in: Cancer Cell Int. 2017 Jul 5;17:67. doi: 10.1186/s12935-017-0436-4. PMID: 26865835 Free PMC article. Retracted.
In this study, we investigated genomic features which affect mutation pattern and the function importance of mutation pattern in cancer. METHODS: Somatic mutations of clear-cell renal cell carcinoma, liver cancer, lung cancer and melanoma and si …
In this study, we investigated genomic features which affect mutation pattern and the function importance of mutation pattern in cancer. MET …
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Boukakis G, Patrinou-Georgoula M, Lekarakou M, Valavanis C, Guialis A. Boukakis G, et al. BMC Cancer. 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434. BMC Cancer. 2010. PMID: 20716340 Free PMC article. Clinical Trial.
The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in human lung cancer and their potential to serve as molecular markers for early diagnosis remain issues of intense investigation. The main objective of the present study was to use paire …
The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in human lung cancer and their potential to ser …
Secreted form of EphA7 in lung cancer.
Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H. Tsuboi M, et al. Int J Oncol. 2010 Mar;36(3):635-40. Int J Oncol. 2010. PMID: 20126984
EPHA7 is a member of the EPHA family of receptor kinases, among which several members are known to be involved in human lung carcinogenesis. We report here a novel spliced variant, the so-called secreted form of EPHA7, recently reported in malignant lymphoma, in hum …
EPHA7 is a member of the EPHA family of receptor kinases, among which several members are known to be involved in human lung carcinog …
Pathogenesis and pathology.
Yesner R. Yesner R. Clin Chest Med. 1993 Mar;14(1):17-30. Clin Chest Med. 1993. PMID: 8384961 Review.
Pathogenesis consists of a discussion of the role of oncogenes and suppressor genes on small-cell lung cancer and non-small-cell lung cancer as well as the external factors of smoking (active and passive), asbestos, and radon. Pathology consists of dis …
Pathogenesis consists of a discussion of the role of oncogenes and suppressor genes on small-cell lung cancer and non-small- …