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29 results

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Page 1
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota.
Akagbosu B, Tayyebi Z, Shibu G, Paucar Iza YA, Deep D, Parisotto YF, Fisher L, Pasolli HA, Thevin V, Elmentaite R, Knott M, Hemmers S, Jahn L, Friedrich C, Verter J, Wang ZM, van den Brink M, Gasteiger G, Grünewald TGP, Marie JC, Leslie C, Rudensky AY, Brown CC. Akagbosu B, et al. Among authors: marie jc. Nature. 2022 Oct;610(7933):752-760. doi: 10.1038/s41586-022-05309-5. Epub 2022 Sep 7. Nature. 2022. PMID: 36070798 Free PMC article.
Whereas TC I and TC III expressed the signature mTEC nuclear factor AIRE, TC IV lacked AIRE expression and was enriched for molecules required for pT(reg) generation, including the TGF-beta-activating integrin alphavbeta8. Loss of either major histocompatibility complex cl …
Whereas TC I and TC III expressed the signature mTEC nuclear factor AIRE, TC IV lacked AIRE expression and was enriched for molecules requir …
An intestinal TH17 cell-derived subset can initiate cancer.
Fesneau O, Thevin V, Pinet V, Goldsmith C, Vieille B, M'Homa Soudja S, Lattanzio R, Hahne M, Dardalhon V, Hernandez-Vargas H, Benech N, Marie JC. Fesneau O, et al. Among authors: marie jc. Nat Immunol. 2024 Sep;25(9):1637-1649. doi: 10.1038/s41590-024-01909-7. Epub 2024 Jul 26. Nat Immunol. 2024. PMID: 39060651 Free PMC article.
Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (T(H)17) cells, induces the spontaneous transformation of the intestinal epithelium. This subset produces inflammatory cytokines, and its tumorigenic potent …
Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (T(H)17) cells, …
TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway.
Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T. Viel S, et al. Among authors: marie jc. Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884. Sci Signal. 2016. PMID: 26884601
Treatment of mouse or human NK cells with TGF-beta in vitro blocked interleukin-15 (IL-15)-induced activation of mTOR. TGF-beta and the mTOR inhibitor rapamycin both reduced the metabolic activity and proliferation of NK cells and reduced the abundances of various N …
Treatment of mouse or human NK cells with TGF-beta in vitro blocked interleukin-15 (IL-15)-induced activation of mTOR. TGF-bet …
Immunomodulatory properties of morbillivirus nucleoproteins.
Kerdiles YM, Cherif B, Marie JC, Tremillon N, Blanquier B, Libeau G, Diallo A, Wild TF, Villiers MB, Horvat B. Kerdiles YM, et al. Among authors: marie jc. Viral Immunol. 2006 Summer;19(2):324-34. doi: 10.1089/vim.2006.19.324. Viral Immunol. 2006. PMID: 16817775
Here, we show that recombinant Morbillivirus nucleoproteins from canine distemper virus, peste-des-petits-ruminants virus, and Rinderpest virus bind B-lymphocytes from dogs, goats, and cattle, respectively, similarly to measles virus nucleoprotein in humans. The use of sur …
Here, we show that recombinant Morbillivirus nucleoproteins from canine distemper virus, peste-des-petits-ruminants virus, and Rinderpest vi …
Injury and inflammation promote cancer progression at the anorectal junction.
Petitpas C, Mitoyan L, Thevin V, Martin M, Hernandez-Vargas H, Chevrier V, Ollivier A, Kaya M, Poizat F, Heinisch M, Rodrigues M, Gameiro-Ferreira L, Ratone JP, Caillol F, Dahel Y, Hoibian S, Giovannini M, de Chaisemartin C, Charafe-Jauffret E, Ginestier C, Marie JC, Guasch G. Petitpas C, et al. Among authors: marie jc. Cell Rep. 2025 Nov 25;44(11):116552. doi: 10.1016/j.celrep.2025.116552. Epub 2025 Nov 13. Cell Rep. 2025. PMID: 41236926 Free article.
We showed that this tumoral development was under the influence of interleukin (IL)-17, a cytokine highly secreted by a gammadelta T lymphocyte subset, allowing the recruitment of neutrophils at the TZ, which was crucial for tumor progression. Hence, this study reve …
We showed that this tumoral development was under the influence of interleukin (IL)-17, a cytokine highly secreted by a gammad …
Integrin alphavbeta8-Mediated TGF-beta Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation.
Worthington JJ, Kelly A, Smedley C, Bauché D, Campbell S, Marie JC, Travis MA. Worthington JJ, et al. Among authors: marie jc. Immunity. 2015 May 19;42(5):903-15. doi: 10.1016/j.immuni.2015.04.012. Epub 2015 May 12. Immunity. 2015. PMID: 25979421 Free PMC article.
Here we show that effector Treg cells express high amounts of the integrin alphavbeta8, which enables them to activate latent transforming growth factor-beta (TGF-beta). Treg-cell-specific deletion of integrin alphavbeta8 did not result in a spontaneous inflammatory phenot …
Here we show that effector Treg cells express high amounts of the integrin alphavbeta8, which enables them to activate latent transforming g …
SMAD4 TGF-beta-independent function preconditions naive CD8+ T cells to prevent severe chronic intestinal inflammation.
Igalouzene R, Hernandez-Vargas H, Benech N, Guyennon A, Bauché D, Barrachina C, Dubois E, Marie JC, Soudja SM. Igalouzene R, et al. Among authors: marie jc. J Clin Invest. 2022 Apr 15;132(8):e151020. doi: 10.1172/JCI151020. J Clin Invest. 2022. PMID: 35426367 Free PMC article.
Mechanistically, prior to TGF-beta signaling, SMAD4 binds to promoters and enhancers of several TGF-beta target genes, and by regulating histone deacetylation, suppresses their expression. Consequently, regardless of a TGF-beta signal, SMAD4 limits the expres …
Mechanistically, prior to TGF-beta signaling, SMAD4 binds to promoters and enhancers of several TGF-beta target genes, and by …
29 results