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Page 1
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota.
Akagbosu B, Tayyebi Z, Shibu G, Paucar Iza YA, Deep D, Parisotto YF, Fisher L, Pasolli HA, Thevin V, Elmentaite R, Knott M, Hemmers S, Jahn L, Friedrich C, Verter J, Wang ZM, van den Brink M, Gasteiger G, Grünewald TGP, Marie JC, Leslie C, Rudensky AY, Brown CC. Akagbosu B, et al. Among authors: marie jc. Nature. 2022 Oct;610(7933):752-760. doi: 10.1038/s41586-022-05309-5. Epub 2022 Sep 7. Nature. 2022. PMID: 36070798 Free PMC article.
Whereas TC I and TC III expressed the signature mTEC nuclear factor AIRE, TC IV lacked AIRE expression and was enriched for molecules required for pT(reg) generation, including the TGF-beta-activating integrin alphavbeta8. Loss of either major histocompatibility complex cl …
Whereas TC I and TC III expressed the signature mTEC nuclear factor AIRE, TC IV lacked AIRE expression and was enriched for molecules requir …
TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway.
Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T. Viel S, et al. Among authors: marie jc. Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884. Sci Signal. 2016. PMID: 26884601
Treatment of mouse or human NK cells with TGF-beta in vitro blocked interleukin-15 (IL-15)-induced activation of mTOR. ...In vivo, constitutive TGF-beta signaling or depletion of mTOR arrested NK cell development, whereas deletion of the TGF-beta receptor sub …
Treatment of mouse or human NK cells with TGF-beta in vitro blocked interleukin-15 (IL-15)-induced activation of mTOR. ...In vivo, co …
SMAD4 TGF-beta-independent function preconditions naive CD8+ T cells to prevent severe chronic intestinal inflammation.
Igalouzene R, Hernandez-Vargas H, Benech N, Guyennon A, Bauché D, Barrachina C, Dubois E, Marie JC, Soudja SM. Igalouzene R, et al. Among authors: marie jc. J Clin Invest. 2022 Apr 15;132(8):e151020. doi: 10.1172/JCI151020. J Clin Invest. 2022. PMID: 35426367 Free PMC article.
Mechanistically, prior to TGF-beta signaling, SMAD4 binds to promoters and enhancers of several TGF-beta target genes, and by regulating histone deacetylation, suppresses their expression. Consequently, regardless of a TGF-beta signal, SMAD4 limits the expres …
Mechanistically, prior to TGF-beta signaling, SMAD4 binds to promoters and enhancers of several TGF-beta target genes, and by …
Development and function of murine RORgammat+ iNKT cells are under TGF-beta signaling control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Havenar-Daughton C, et al. Among authors: marie jc. Blood. 2012 Apr 12;119(15):3486-94. doi: 10.1182/blood-2012-01-401604. Epub 2012 Feb 27. Blood. 2012. PMID: 22371886 Free article.
We reveal that TGF-beta signaling, and particularly its SMAD4-dependent pathway, is required for both the survival of RORgammat(+) iNKT cells during their development and IL-17 production at the periphery. ...Thus, this work demonstrates that both the develop …
We reveal that TGF-beta signaling, and particularly its SMAD4-dependent pathway, is required for both the survival of RORgammat(+) iN …
Productive measles virus brain infection and apoptosis in CD46 transgenic mice.
Evlashev A, Moyse E, Valentin H, Azocar O, Trescol-Biémont MC, Marie JC, Rabourdin-Combe C, Horvat B. Evlashev A, et al. Among authors: marie jc. J Virol. 2000 Feb;74(3):1373-82. doi: 10.1128/jvi.74.3.1373-1382.2000. J Virol. 2000. PMID: 10627548 Free PMC article.
To develop a murine model of MV-induced pathology, we generated several lines of transgenic mice ubiquitously expressing as the MV receptor a human CD46 molecule with either a Cyt1 or Cyt2 cytoplasmic tail. All transgenic lines expressed CD46 protein in the b …
To develop a murine model of MV-induced pathology, we generated several lines of transgenic mice ubiquitously expressing as the MV receptor …
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions.
Bauché D, Marie JC. Bauché D, et al. Among authors: marie jc. Clin Transl Immunology. 2017 Apr 7;6(4):e136. doi: 10.1038/cti.2017.9. eCollection 2017 Apr. Clin Transl Immunology. 2017. PMID: 28523126 Free PMC article. Review.
In this review, we define the functional impact of transforming growth factor-beta (TGF-beta) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B c …
In this review, we define the functional impact of transforming growth factor-beta (TGF-beta) on this complex interplay, especially t …
Common and Exclusive Features of Intestinal Intraepithelial γδ T Cells and Other γδ T Cell Subsets.
Apostolov AK, Hamani M, Hernandez-Vargas H, Igalouzene R, Guyennon A, Fesneau O, Marie JC, Soudja SM. Apostolov AK, et al. Among authors: marie jc. Immunohorizons. 2022 Jul 25;6(7):515-527. doi: 10.4049/immunohorizons.2200046. Immunohorizons. 2022. PMID: 35878935 Free article.
The marked expression of Helios is also shared by the other iIELs, TCRalphabetaCD8alphaalpha lymphocytes present within the intestinal epithelium. Finally, we show that Helios expression depends in part on TGF-beta signaling but not on the microbiota. Thus, our study propo …
The marked expression of Helios is also shared by the other iIELs, TCRalphabetaCD8alphaalpha lymphocytes present within the intestinal epith …
TGF-beta prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron MJ, Marie JC. McCarron MJ, et al. Among authors: marie jc. J Clin Invest. 2014 Oct;124(10):4375-86. doi: 10.1172/JCI76179. Epub 2014 Aug 26. J Clin Invest. 2014. PMID: 25157822 Free PMC article.
Using mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demonstrated that TGF-beta signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regula …
Using mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demonstrated that TGF-beta si …
26 results