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Page 1
Ciliary dysfunction and obesity.
Mok CA, Héon E, Zhen M. Mok CA, et al. Among authors: heon e, zhen m. Clin Genet. 2010 Jan;77(1):18-27. doi: 10.1111/j.1399-0004.2009.01305.x. Epub 2009 Nov 20. Clin Genet. 2010. PMID: 19968672
MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes.
Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH. Mok CA, et al. Among authors: waterston rh. Genetics. 2017 Oct;207(2):447-463. doi: 10.1534/genetics.117.300179. Epub 2017 Aug 21. Genetics. 2017. PMID: 28827289 Free PMC article.
Mutants remain a powerful means for dissecting gene function in model organisms such as Caenorhabditis elegans Massively parallel sequencing has simplified the detection of variants after mutagenesis but determining precisely which change is responsible for phenotypic pert …
Mutants remain a powerful means for dissecting gene function in model organisms such as Caenorhabditis elegans Massively parallel seq …
An intestinally secreted host factor promotes microsporidia invasion of C. elegans.
Tamim El Jarkass H, Mok C, Schertzberg MR, Fraser AG, Troemel ER, Reinke AW. Tamim El Jarkass H, et al. Among authors: reinke aw, mok c. Elife. 2022 Jan 7;11:e72458. doi: 10.7554/eLife.72458. Elife. 2022. PMID: 34994689 Free PMC article.
To identify such factors necessary for infection by Nematocida parisii, a natural microsporidian pathogen of Caenorhabditis elegans, we performed a forward genetic screen to identify mutant animals that have a Fitness Advantage with Nematocida (Fawn). ...
To identify such factors necessary for infection by Nematocida parisii, a natural microsporidian pathogen of Caenorhabditis elegans, …
High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits.
Mok C, Xiao MA, Wan YC, Zhao W, Ahmed SM, Luallen RJ, Reinke AW. Mok C, et al. Among authors: reinke aw. PLoS Pathog. 2023 Mar 9;19(3):e1011225. doi: 10.1371/journal.ppat.1011225. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 36893187 Free PMC article.
Using multiplexed competition assays, we measured the impact of four different species of microsporidia on 22 wild isolates of Caenorhabditis elegans. This resulted in the identification and confirmation of 13 strains with significantly altered population fitness profiles …
Using multiplexed competition assays, we measured the impact of four different species of microsporidia on 22 wild isolates of Caenorhabditi …
PhenoMIP: High-Throughput Phenotyping of Diverse Caenorhabditis elegans Populations via Molecular Inversion Probes.
Mok C, Belmarez G, Edgley ML, Moerman DG, Waterston RH. Mok C, et al. Among authors: waterston rh. G3 (Bethesda). 2020 Nov 5;10(11):3977-3990. doi: 10.1534/g3.120.401656. G3 (Bethesda). 2020. PMID: 32868407 Free PMC article.
Whether generated within a lab setting or isolated from the wild, variant alleles continue to be an important resource for decoding gene function in model organisms such as Caenorhabditis elegans With advances in massively parallel sequencing, multiple whole-genome sequenc …
Whether generated within a lab setting or isolated from the wild, variant alleles continue to be an important resource for decoding gene fun …
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.
Li C, Inglis PN, Leitch CC, Efimenko E, Zaghloul NA, Mok CA, Davis EE, Bialas NJ, Healey MP, Héon E, Zhen M, Swoboda P, Katsanis N, Leroux MR. Li C, et al. Among authors: mok ca, heon e, zhen m. PLoS Genet. 2008 Mar 28;4(3):e1000044. doi: 10.1371/journal.pgen.1000044. PLoS Genet. 2008. PMID: 18369462 Free PMC article.
MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 (Disrupted-in-Schizophrenia 1), but whose cellular function(s) remains unknown. Here we demonstrate that the C. elegans MIP-T3 ortholog DYF-11 is an …
MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 (Disrupted-in-S …
Challenges and Approaches to Genotyping Repetitive DNA.
Morton EA, Hall AN, Kwan E, Mok C, Queitsch K, Nandakumar V, Stamatoyannopoulos J, Brewer BJ, Waterston R, Queitsch C. Morton EA, et al. Among authors: mok c. G3 (Bethesda). 2020 Jan 7;10(1):417-430. doi: 10.1534/g3.119.400771. G3 (Bethesda). 2020. PMID: 31757929 Free PMC article.
We present a resource of high-confidence rDNA copy number estimates for a set of S. cerevisiae and C. elegans strains for future use. We furthermore explore the possibility for FISH-based copy number estimation, an alternative that could potentially characterize copy numbe …
We present a resource of high-confidence rDNA copy number estimates for a set of S. cerevisiae and C. elegans strains for future use. …
Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M. Mok CA, et al. Among authors: heon e, zhen m. PLoS Genet. 2011 Oct;7(10):e1002335. doi: 10.1371/journal.pgen.1002335. Epub 2011 Oct 13. PLoS Genet. 2011. PMID: 22022287 Free PMC article.
Here we report the identification of mutations in guanylate cyclases (GCYs) as modifiers of Caenorhabditis elegans bbs endophenotypes. The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by mult …
Here we report the identification of mutations in guanylate cyclases (GCYs) as modifiers of Caenorhabditis elegans bbs endophenotypes …
11 results