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Year Number of Results
1997 1
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2001 4
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2004 4
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2007 5
2008 1
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2010 12
2011 7
2012 10
2013 9
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225 results

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Page 1
Semaglutide lowers body weight in rodents via distributed neural pathways.
Gabery S, Salinas CG, Paulsen SJ, Ahnfelt-Rønne J, Alanentalo T, Baquero AF, Buckley ST, Farkas E, Fekete C, Frederiksen KS, Helms HCC, Jeppesen JF, John LM, Pyke C, Nøhr J, Lu TT, Polex-Wolf J, Prevot V, Raun K, Simonsen L, Sun G, Szilvásy-Szabó A, Willenbrock H, Secher A, Knudsen LB, Hogendorf WFJ. Gabery S, et al. Among authors: prevot v. JCI Insight. 2020 Mar 26;5(6):e133429. doi: 10.1172/jci.insight.133429. JCI Insight. 2020. PMID: 32213703 Free PMC article.
Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here show that semaglutide modulated food preference, reduced food intake, and caused weight loss without decreasing energy expenditure. S …
Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presente …
Hypothalamic bile acid-TGR5 signaling protects from obesity.
Castellanos-Jankiewicz A, Guzmán-Quevedo O, Fénelon VS, Zizzari P, Quarta C, Bellocchio L, Tailleux A, Charton J, Fernandois D, Henricsson M, Piveteau C, Simon V, Allard C, Quemener S, Guinot V, Hennuyer N, Perino A, Duveau A, Maitre M, Leste-Lasserre T, Clark S, Dupuy N, Cannich A, Gonzales D, Deprez B, Mithieux G, Dombrowicz D, Bäckhed F, Prevot V, Marsicano G, Staels B, Schoonjans K, Cota D. Castellanos-Jankiewicz A, et al. Among authors: prevot v. Cell Metab. 2021 Jul 6;33(7):1483-1492.e10. doi: 10.1016/j.cmet.2021.04.009. Epub 2021 Apr 21. Cell Metab. 2021. PMID: 33887197 Free article.
TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. ...Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothala …
TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesi …
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions.
Imbernon M, Saponaro C, Helms HCC, Duquenne M, Fernandois D, Deligia E, Denis RGP, Chao DHM, Rasika S, Staels B, Pattou F, Pfrieger FW, Brodin B, Luquet S, Bonner C, Prevot V. Imbernon M, et al. Among authors: prevot v. Cell Metab. 2022 Jul 5;34(7):1054-1063.e7. doi: 10.1016/j.cmet.2022.06.002. Epub 2022 Jun 17. Cell Metab. 2022. PMID: 35716660 Free PMC article.
Here, we demonstrate that liraglutide is shuttled to target cells in the mouse hypothalamus by specialized ependymoglial cells called tanycytes, bypassing the blood-brain barrier. ...Collectively, these striking data indicate that the liraglutid …
Here, we demonstrate that liraglutide is shuttled to target cells in the mouse hypothalamus by specialized ependymoglial …
A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.
Benevento M, Alpár A, Gundacker A, Afjehi L, Balueva K, Hevesi Z, Hanics J, Rehman S, Pollak DD, Lubec G, Wulff P, Prevot V, Horvath TL, Harkany T. Benevento M, et al. Among authors: prevot v. Nature. 2024 Apr;628(8009):826-834. doi: 10.1038/s41586-024-07232-3. Epub 2024 Mar 27. Nature. 2024. PMID: 38538787 Free PMC article.
Here we show that tanycytes are activated upon acute thermal challenge and are necessary to reduce food intake afterwards. Virus-mediated gene manipulation and circuit mapping showed that thermosensing glutamatergic neurons of the parabrachial nucleus innervate tanycyte …
Here we show that tanycytes are activated upon acute thermal challenge and are necessary to reduce food intake afterwards. Virus-medi …
GnRH and Cognition.
Kacimi L, Prevot V. Kacimi L, et al. Among authors: prevot v. Endocrinology. 2025 Feb 27;166(4):bqaf033. doi: 10.1210/endocr/bqaf033. Endocrinology. 2025. PMID: 39996304 Free article. Review.
GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal axis. ...This review highlights recent advances in our understanding of the GnRH system and the therapeutic po …
GnRH is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothal …
Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.
Collado-Sole A, Borjini N, Zhai J, Ruiz-Pino F, Soria-Alcaide G, Folgueira C, García-Vilela C, Romero-de la Rosa B, Lopez V, Zouaghi Y, Jacobs A, Mora-Romero B, Barranco A, Yoldi G, Rizzoti K, Sabio G, Perez-Chacon G, Santamaria PG, Esteban JA, Journiac N, Prevot V, Pascual A, Fernández-Chacón R, Tena-Sempere M, Pitteloud N, Gonzalez-Suarez E. Collado-Sole A, et al. Among authors: prevot v. Science. 2026 May 21;392(6800):eaeb6999. doi: 10.1126/science.aeb6999. Epub 2026 May 21. Science. 2026. PMID: 41818388 Free PMC article.
Whole-body and microglia Rank (mouse) depletion led to hypogonadotropic hypogonadism (HH) resulting from an alteration in gonadotropin-releasing hormone (GnRH) neuron function. In addition, we identified rare gene variants of RANK (human) in patients w …
Whole-body and microglia Rank (mouse) depletion led to hypogonadotropic hypogonadism (HH) resulting from an alteration in gonadotropin …
Kisspeptin signaling in astrocytes modulates the reproductive axis.
Torres E, Pellegrino G, Granados-Rodríguez M, Fuentes-Fayos AC, Velasco I, Coutteau-Robles A, Legrand A, Shanabrough M, Perdices-Lopez C, Leon S, Yeo SH, Manchishi SM, Sánchez-Tapia MJ, Navarro VM, Pineda R, Roa J, Naftolin F, Argente J, Luque RM, Chowen JA, Horvath TL, Prevot V, Sharif A, Colledge WH, Tena-Sempere M, Romero-Ruiz A. Torres E, et al. Among authors: prevot v. J Clin Invest. 2024 Jun 11;134(15):e172908. doi: 10.1172/JCI172908. J Clin Invest. 2024. PMID: 38861336 Free PMC article.
Cellular coexpression of Kiss1r with the astrocyte markers GFAP and S100-beta occurred in different brain regions, with higher percentage in Kiss1- and GnRH-enriched areas. Conditional ablation of Kiss1r in GFAP-positive cells in the G-KiR-KO mouse altered ge …
Cellular coexpression of Kiss1r with the astrocyte markers GFAP and S100-beta occurred in different brain regions, with higher percen …
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.
Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, Quinton R, Young J. Boehm U, et al. Among authors: prevot v. Nat Rev Endocrinol. 2015 Sep;11(9):547-64. doi: 10.1038/nrendo.2015.112. Epub 2015 Jul 21. Nat Rev Endocrinol. 2015. PMID: 26194704 Review.
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which is the master hormone regulating the reproductive axis. ...The association …
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the deficient production, secretion or action of gonadotropin …
GnRH replacement rescues cognition in Down syndrome.
Manfredi-Lozano M, Leysen V, Adamo M, Paiva I, Rovera R, Pignat JM, Timzoura FE, Candlish M, Eddarkaoui S, Malone SA, Silva MSB, Trova S, Imbernon M, Decoster L, Cotellessa L, Tena-Sempere M, Claret M, Paoloni-Giacobino A, Plassard D, Paccou E, Vionnet N, Acierno J, Maceski AM, Lutti A, Pfrieger F, Rasika S, Santoni F, Boehm U, Ciofi P, Buée L, Haddjeri N, Boutillier AL, Kuhle J, Messina A, Draganski B, Giacobini P, Pitteloud N, Prevot V. Manfredi-Lozano M, et al. Among authors: prevot v. Science. 2022 Sep 2;377(6610):eabq4515. doi: 10.1126/science.abq4515. Epub 2022 Sep 2. Science. 2022. PMID: 36048943 Free PMC article.
We show in a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel a postpubertal decrease in hypothalamic as well as extrahypothalamic expression of a master molecule that controls reproduction-gonadotropin-releasing …
We show in a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel a postpubertal decrease in …
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.
Pena-Leon V, Folgueira C, Barja-Fernández S, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R, Seoane LM. Pena-Leon V, et al. Among authors: prevot v. Nat Metab. 2022 Jul;4(7):901-917. doi: 10.1038/s42255-022-00602-z. Epub 2022 Jul 25. Nat Metab. 2022. PMID: 35879461 Free PMC article.
In-depth metabolic phenotyping in this rat model as well as in transgenic mice reveals that the effects of prolonged suckling are mediated by increased hepatic fibroblast growth factor 21 (FGF21) production and tanycyte-controlled access to the hypothalamus in adult …
In-depth metabolic phenotyping in this rat model as well as in transgenic mice reveals that the effects of prolonged suckling are mediated b …
225 results