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Non-pharmacological interventions for improving language and communication in people with primary progressive aphasia.
Roheger M, Riemann S, Brauer A, McGowan E, Grittner U, Flöel A, Meinzer M. Roheger M, et al. Cochrane Database Syst Rev. 2024 May 29;5(5):CD015067. doi: 10.1002/14651858.CD015067.pub2. Cochrane Database Syst Rev. 2024. PMID: 38808659 Review.
BACKGROUND: Primary progressive aphasia (PPA) accounts for approximately 43% of frontotemporal dementias and is mainly characterised by a progressive impairment of speech and communication abilities. Three clinical variants have been identified: …
BACKGROUND: Primary progressive aphasia (PPA) accounts for approximately 43% of frontotemporal dementias and is mainly …
The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.
Ramanan S, Halai AD, Garcia-Penton L, Perry AG, Patel N, Peterson KA, Ingram RU, Storey I, Cappa SF, Catricala E, Patterson K, Rowe JB, Garrard P, Ralph MAL. Ramanan S, et al. Alzheimers Res Ther. 2023 Dec 16;15(1):219. doi: 10.1186/s13195-023-01350-2. Alzheimers Res Ther. 2023. PMID: 38102724 Free PMC article.
BACKGROUND: Clinical variants of primary progressive aphasia (PPA) are diagnosed based on characteristic patterns of language deficits, supported by corresponding neural changes on brain imaging. ...Understanding the relationship between these variable …
BACKGROUND: Clinical variants of primary progressive aphasia (PPA) are diagnosed based on characteristic pattern …
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.
Illán-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gómez-Andrés D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Mandelli ML, Gorno-Tempini ML. Illán-Gala I, et al. Brain. 2024 Apr 4;147(4):1511-1525. doi: 10.1093/brain/awad396. Brain. 2024. PMID: 37988272 Free PMC article.
It is debated whether primary progressive apraxia of speech (PPAOS) and progressive agrammatic aphasia (PAA) belong to the same clinical spectrum, traditionally termed non-fluent/agrammatic variant primary progressive
It is debated whether primary progressive apraxia of speech (PPAOS) and progressive agrammatic aphasia (PAA) bel …
Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.
Hardy CJD, Taylor-Rubin C, Taylor B, Harding E, Gonzalez AS, Jiang J, Thompson L, Kingma R, Chokesuwattanaskul A, Walker F, Barker S, Brotherhood E, Waddington C, Wood O, Zimmermann N, Kupeli N, Yong KXX, Camic PM, Stott J, Marshall CR, Oxtoby NP, Rohrer JD, Volkmer A, Crutch SJ, Warren JD. Hardy CJD, et al. Alzheimers Dement. 2024 Jan;20(1):195-210. doi: 10.1002/alz.13415. Epub 2023 Aug 7. Alzheimers Dement. 2024. PMID: 37548125 Free PMC article.
INTRODUCTION: Here we set out to create a symptom-led staging system for the canonical semantic and non-fluent/agrammatic variants of primary progressive aphasia (PPA), which present unique diagnostic and management challenges not well captured …
INTRODUCTION: Here we set out to create a symptom-led staging system for the canonical semantic and non-fluent/agrammatic vari …
Symptom-led staging for primary progressive aphasia.
Hardy CJ, Taylor-Rubin C, Taylor B, Harding E, Gonzalez AS, Jiang J, Thompson L, Kingma R, Chokesuwattanaskul A, Walker F, Barker S, Brotherhood E, Waddington C, Wood O, Zimmermann N, Kupeli N, Yong KX, Camic PM, Stott J, Marshall CR, Oxtoby NP, Rohrer JD, Volkmer A, Crutch SJ, Warren JD. Hardy CJ, et al. medRxiv [Preprint]. 2023 Mar 17:2023.03.13.23286972. doi: 10.1101/2023.03.13.23286972. medRxiv. 2023. Update in: Alzheimers Dement. 2024 Jan;20(1):195-210. doi: 10.1002/alz.13415. PMID: 36993460 Free PMC article. Updated. Preprint.
The primary progressive aphasias (PPA) present complex and diverse challenges of diagnosis, management and prognosis. ...Our findings have implications for diagnostic and care pathway guidelines, trial design and personalised prognosis and treatment for peopl …
The primary progressive aphasias (PPA) present complex and diverse challenges of diagnosis, management and prognosis. ...Our f …
The ScreeLing: Detecting Semantic, Phonological, and Syntactic Deficits in the Clinical Subtypes of Frontotemporal and Alzheimer's Dementia.
Jiskoot LC, Poos JM, van Boven K, de Boer L, Giannini LAA, Satoer DD, Visch-Brink EG, van Hemmen J, Franzen S, Pijnenburg YAL, van den Berg E, Seelaar H. Jiskoot LC, et al. Assessment. 2023 Dec;30(8):2545-2559. doi: 10.1177/10731911231154512. Epub 2023 Feb 17. Assessment. 2023. PMID: 36799220 Free PMC article.
Its ability to differentiate between the clinical subtypes of FTD and AD is, however, still unknown. We investigated differences in ScreeLing total and subscores, linguistic-level disorders' relationship with disease severity, and classification abilities, in patients with …
Its ability to differentiate between the clinical subtypes of FTD and AD is, however, still unknown. We investigated differences in S …
Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.
Logroscino G, Piccininni M, Graff C, Hardiman O, Ludolph AC, Moreno F, Otto M, Remes AM, Rowe JB, Seelaar H, Solje E, Stefanova E, Traykov L, Jelic V, Rydell MT, Pender N, Anderl-Straub S, Barandiaran M, Gabilondo A, Krüger J, Murley AG, Rittman T, van der Ende EL, van Swieten JC, Hartikainen P, Stojmenovic GM, Mehrabian S, Benussi L, Alberici A, Dell'Abate MT, Zecca C, Borroni B; FRONTIERS group. Logroscino G, et al. JAMA Neurol. 2023 Mar 1;80(3):279-286. doi: 10.1001/jamaneurol.2022.5128. JAMA Neurol. 2023. PMID: 36716024 Free PMC article.
Included patients fulfilled criteria for the behavioral variant of frontotemporal dementia (BVFTD), the nonfluent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, progressive supranuclear palsy, corticobasal syn …
Included patients fulfilled criteria for the behavioral variant of frontotemporal dementia (BVFTD), the nonfluent variant or semantic …
Treatment of primary progressive aphasia by repetitive transcranial magnetic stimulation: a randomized, double-blind, placebo-controlled study.
Huang Y, Tan Y, Hao H, Li J, Liu C, Hu Y, Wu Y, Ding Q, Zhou Y, Li Y, Guan Y. Huang Y, et al. J Neural Transm (Vienna). 2023 Feb;130(2):111-123. doi: 10.1007/s00702-023-02594-w. Epub 2023 Jan 20. J Neural Transm (Vienna). 2023. PMID: 36662282 Clinical Trial.
To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with primary progressive aphasia (PPA). In this randomized, double-blind trial in a single center, patients who were diagnosed with PPA we …
To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with primary progressiv
Genotype-phenotype correlation in the spectrum of frontotemporal dementia-parkinsonian syndromes and advanced diagnostic approaches.
Zecca C, Tortelli R, Carrera P, Dell'Abate MT, Logroscino G, Ferrari M. Zecca C, et al. Crit Rev Clin Lab Sci. 2023 May;60(3):171-188. doi: 10.1080/10408363.2022.2150833. Epub 2022 Dec 12. Crit Rev Clin Lab Sci. 2023. PMID: 36510705 Review.
Based on clinical presentation, three main clinical syndromes have traditionally been described: behavioral variant frontotemporal dementia (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfPPA), and semantic variant PP …
Based on clinical presentation, three main clinical syndromes have traditionally been described: behavioral variant frontotemp …
Transcranial Direct Current Stimulation Paired With Verb Network Strengthening Treatment Improves Verb Naming in Primary Progressive Aphasia: A Case Series.
Sheppard SM, Goldberg EB, Sebastian R, Walker A, Meier EL, Hillis AE. Sheppard SM, et al. Am J Speech Lang Pathol. 2022 Jul 12;31(4):1736-1754. doi: 10.1044/2022_AJSLP-21-00272. Epub 2022 May 23. Am J Speech Lang Pathol. 2022. PMID: 35605599 Free PMC article. Clinical Trial.
PURPOSE: There are few evidence-based treatments for language deficits in primary progressive aphasia (PPA). PPA treatments are often adopted from the poststroke aphasia literature. ...One participant with nonfluent variant also showed evidence …
PURPOSE: There are few evidence-based treatments for language deficits in primary progressive aphasia (PPA). PPA treatm …
54 results