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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1975 3
1977 3
1978 4
1979 4
1980 5
1981 12
1982 16
1983 12
1984 16
1985 16
1986 16
1987 27
1988 15
1989 17
1990 24
1991 20
1992 20
1993 35
1994 25
1995 29
1996 38
1997 35
1998 36
1999 54
2000 38
2001 62
2002 57
2003 63
2004 77
2005 83
2006 63
2007 75
2008 92
2009 94
2010 102
2011 101
2012 118
2013 148
2014 141
2015 149
2016 128
2017 118
2018 110
2019 123
2020 172
2021 170
2022 105
2023 93
2024 26

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2,654 results

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Page 1
QTc prolongation after aneurysmal subarachnoid hemorrhage might be associated with worse neurologic outcome in patients receiving microsurgical clipping or embolization of the intracranial aneurysms: a retrospective observational study.
Zhang X, Lei Y, Nan L, Dong S, Liu Y, Yu J, Xu K, Hou K, Ma H. Zhang X, et al. BMC Neurol. 2024 May 23;24(1):170. doi: 10.1186/s12883-024-03679-z. BMC Neurol. 2024. PMID: 38783204
Whether corrected QT interval (QTc) prolongation is associated with perioperative cardiac events and dismal neurological outcome in mid to long-term follow-up in patients after aSAH is insufficiently studied and remains controversial. ...After PSM, there was …
Whether corrected QT interval (QTc) prolongation is associated with perioperative cardiac events and dismal neurologica …
Diagnostic Indicators of ECG for Coronary Slow Flow Phenomenon; a Systematic Review and Meta-Analysis.
MozafaryBazargany M, Samimisedeh P, Gholami N, Jafari Afshar E, Memari A, Yazdani S, Rastad H. MozafaryBazargany M, et al. Arch Acad Emerg Med. 2024 Mar 3;12(1):e34. doi: 10.22037/aaem.v12i1.2202. eCollection 2024. Arch Acad Emerg Med. 2024. PMID: 38721444 Free PMC article. Review.
CSFP patients had higher P-wave maximum (Pmax) (SMD: 1.02 (95% confidence interval (CI): 0.29 - 1.76); p=0.006) and P-dispersion (Pd) (SMD: 1.63 (95% CI: 0.99 - 2.27); p<0.001) compared to the control group. ...CONCLUSION: Our findings suggest several ECG parameters, su …
CSFP patients had higher P-wave maximum (Pmax) (SMD: 1.02 (95% confidence interval (CI): 0.29 - 1.76); p=0.006) and P-dispersion (Pd) …
Concentration-QTc modeling of sitravatinib in patients with advanced solid malignancies.
Dickinson A, Liu Y, Uvarov A, Peyret T, Marier JF, Chin C, Tran JQ. Dickinson A, et al. Clin Transl Sci. 2024 May;17(5):e13808. doi: 10.1111/cts.13808. Clin Transl Sci. 2024. PMID: 38700272 Free PMC article.
Sitravatinib (MGCD516) is an orally available, small molecule, tyrosine kinase inhibitor that has been evaluated in patients with advanced solid tumors. Concentration-corrected QT interval (QTc; C-QTc) modeling was undertaken, using 767 matched concentration- …
Sitravatinib (MGCD516) is an orally available, small molecule, tyrosine kinase inhibitor that has been evaluated in patients with advanced s …
Clearing the Fog: A Review of Antipsychotics for Parkinson's-Related Hallucinations: A Focus on Pimavanserin, Quetiapine and Clozapine.
Abdul-Rahman T, Herrera-Calderón RE, Aderinto N, Kundu M, Wireko AA, Adebusoye FT, Ekerin O, Lawal L, Mykolaivna NI, Alexiou A, Almashjary MN, Perveen A, Ashraf GM. Abdul-Rahman T, et al. J Integr Neurosci. 2024 Apr 12;23(4):80. doi: 10.31083/j.jin2304080. J Integr Neurosci. 2024. PMID: 38682215 Free article. Review.
Pimavanserin, a selective serotonin inverse agonist, avoids receptor-related side effects but has been linked to corrected QT (QTc) interval prolongation, while quetiapine has been reported to be associated with an increased risk of mortality. ...
Pimavanserin, a selective serotonin inverse agonist, avoids receptor-related side effects but has been linked to corrected QT (QTc) …
Semaglutide attenuates pathological electrophysiological remodeling in diabetic cardiomyopathy via restoring Cx43 expression.
Yan M, Lin K, Huang D, Li J, Qu X, Chen K. Yan M, et al. Endocrine. 2024 Apr 22. doi: 10.1007/s12020-024-03823-2. Online ahead of print. Endocrine. 2024. PMID: 38647981
This study aimed to evaluate the effects of semaglutide on myocardium injury and cardiac function in DCM mice and its potential mechanisms, with emphasis on its effects on Cx43 and electrophysiological remodeling. METHODS: C57BL/6 mice were randomly divided into four group …
This study aimed to evaluate the effects of semaglutide on myocardium injury and cardiac function in DCM mice and its potential mechanisms, …
Randomized, placebo-controlled, double-blind phase I trial of co-administered pyronaridine and piperaquine in healthy adults of sub-Saharan origin.
Kuemmerle A, Gossen D, Janin A, Stokes A, Abla N, Szramowska M, Lorch U, El Gaaloul M, Borghini-Fuhrer I, Chalon S. Kuemmerle A, et al. Clin Transl Sci. 2024 Apr;17(4):e13738. doi: 10.1111/cts.13738. Clin Transl Sci. 2024. PMID: 38594824 Free PMC article. Clinical Trial.
Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria. This randomized, double-blind, placebo-controlled (double-dummy), parallel-group, single site ph …
Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnera …
The pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients.
Knuijver T, Ter Heine R, Schellekens AFA, Heydari P, Lucas L, Westra S, Belgers M, van Oosteren T, Verkes RJ, Kramers C. Knuijver T, et al. J Psychopharmacol. 2024 May;38(5):481-488. doi: 10.1177/02698811241237873. Epub 2024 Mar 22. J Psychopharmacol. 2024. PMID: 38519421 Free PMC article.
The relationships between pharmacokinetics (PKs) of ibogaine and its metabolites and their clinical effects on side effects and opioid withdrawal severity are unknown. ...The PKs were analyzed by means of nonlinear mixed effects modeling and related with corrected QT in
The relationships between pharmacokinetics (PKs) of ibogaine and its metabolites and their clinical effects on side effects and opioi …
Bioelectrical Impedance Phase Angle Value and Prolongations of PR and Corrected QT Intervals in Patients Undergoing Dialysis.
Shibata M, Asai K, Nagai K, Taniguchi S. Shibata M, et al. Cardiorenal Med. 2024;14(1):215-226. doi: 10.1159/000538305. Epub 2024 Mar 20. Cardiorenal Med. 2024. PMID: 38508154 Free article.
The ECG was recorded simultaneously, and the upper limits of the PR interval, QRS width, and corrected QT interval (QTc) were set at 0.20, 0.12, and 0.44 s, respectively. ...The prevalence of QTc prolongation was higher in females and diabetic p …
The ECG was recorded simultaneously, and the upper limits of the PR interval, QRS width, and corrected QT interval (QTc
Virtual clinical QT exposure-response studies - A translational computational approach.
Aguado-Sierra J, Dominguez-Gomez P, Amar A, Butakoff C, Leitner M, Schaper S, Kriegl JM, Darpo B, Vazquez M, Rast G. Aguado-Sierra J, et al. J Pharmacol Toxicol Methods. 2024 Mar-Apr;126:107498. doi: 10.1016/j.vascn.2024.107498. Epub 2024 Mar 1. J Pharmacol Toxicol Methods. 2024. PMID: 38432528 Free article.
The concentration-response relationship of the QT-interval prolongation obtained from the computational cardiac population was compared against the relationship from clinical trial data for a set of well-characterized compounds: moxifloxacin, dofetilid …
The concentration-response relationship of the QT-interval prolongation obtained from the computational cardiac population was …
Characterization of cardiovascular profile of anti-influenza drug peramivir: A reverse-translational study using the isoflurane-anesthetized dog.
Kambayashi R, Goto A, Izumi-Nakaseko H, Takei Y, Sugiyama A. Kambayashi R, et al. J Pharmacol Sci. 2024 Mar;154(3):218-224. doi: 10.1016/j.jphs.2024.02.002. Epub 2024 Feb 2. J Pharmacol Sci. 2024. PMID: 38395523 Free article.
An injectable anti-influenza drug peramivir has been reported to induce QT-interval prolongation in some phase III studies, although its thorough QT/QTc study was negative. ...Peramivir prolonged T(peak)-T(end) and tended to prolong terminal rep …
An injectable anti-influenza drug peramivir has been reported to induce QT-interval prolongation in some phase III studies, al …
2,654 results