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Year Number of Results
2013 1
2014 2
2015 3
2016 5
2017 2
2018 6
2019 2
2020 1
2021 3
2022 4
2023 3
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30 results

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Page 1
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.
Knights AJ, Farrell EC, Ellis OM, Lammlin L, Junginger LM, Rzeczycki PM, Bergman RF, Pervez R, Cruz M, Knight E, Farmer D, Samani AA, Wu CL, Hankenson KD, Maerz T. Knights AJ, et al. Ann Rheum Dis. 2023 Feb;82(2):272-282. doi: 10.1136/ard-2022-222773. Epub 2022 Sep 29. Ann Rheum Dis. 2023. PMID: 36175067 Free PMC article.
We performed single-cell RNA-sequencing to assess synovial cell populations, subjected Wnt-GFP reporter mice to joint injury to study Wnt-active cells, and performed intra-articular injections of the Wnt agonist R-spondin 2 (Rspo2) to assess whether ga …
We performed single-cell RNA-sequencing to assess synovial cell populations, subjected Wnt-GFP reporter mice to joint injury to study Wnt-ac …
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2.
Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D, Bai X. Zhang H, et al. Ann Rheum Dis. 2018 Oct;77(10):1524-1534. doi: 10.1136/annrheumdis-2018-213450. Epub 2018 Jul 10. Ann Rheum Dis. 2018. PMID: 29991473
Cartilage damage and osteophyte size were measured by Osteoarthritis Research Society International score and micro-CT, respectively. mRNA sequencing was performed in M1 and control macrophages. Mice and ATDC5 cells were treated with R-spondin-2 (Rspo2 …
Cartilage damage and osteophyte size were measured by Osteoarthritis Research Society International score and micro-CT, respectively. mRNA s …
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z, Li Z, Yang Z, Li R, Xue X, Gao Y, Yue F, Zhang XH, Hu G, Wang Y, Li Y, Chen G, Siwko S, Gartland A, Wang N, Xiao J, Liu M, Luo J. Yue Z, et al. J Clin Invest. 2022 Jan 18;132(2):e144579. doi: 10.1172/JCI144579. J Clin Invest. 2022. PMID: 34847079 Free PMC article.
At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested that R-spondin 2 (RSPO2) and RANKL, through interaction with their receptor LGR4, promoted osteoclastic premetastatic niche formation and enhanced BCa bone metastasis …
At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested that R-spondin 2 (RSPO2) a …
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Singla B, Lin HP, Chen A, Ahn W, Ghoshal P, Cherian-Shaw M, White J, Stansfield BK, Csányi G. Singla B, et al. Cardiovasc Res. 2021 May 25;117(6):1489-1509. doi: 10.1093/cvr/cvaa244. Cardiovasc Res. 2021. PMID: 32750106 Free PMC article.
Our studies identified elevated levels of matrix protein R-spondin 2 (RSPO2) in atherosclerotic arteries. In this study, we investigated the role of RSPO2 in lymphangiogenesis, arterial cholesterol efflux into lesion-draining lymph nodes (LNs) a …
Our studies identified elevated levels of matrix protein R-spondin 2 (RSPO2) in atherosclerotic arteries. In thi …
R-Spondin-2 Is Upregulated in Idiopathic Pulmonary Fibrosis and Affects Fibroblast Behavior.
Munguía-Reyes A, Balderas-Martínez YI, Becerril C, Checa M, Ramírez R, Ortiz B, Meléndez-Zajgla J, Pardo A, Selman M. Munguía-Reyes A, et al. Am J Respir Cell Mol Biol. 2018 Jul;59(1):65-76. doi: 10.1165/rcmb.2017-0115OC. Am J Respir Cell Mol Biol. 2018. PMID: 29345973
Interestingly, RSPO2 participates in the canonical Wingless/int1 pathway, a critical route in the pathogenesis of IPF. ...Silencing RSPO2 with shRNA induced the opposite effects. Our findings demonstrate, for the first time to our knowledge, that RSPO2 is upr …
Interestingly, RSPO2 participates in the canonical Wingless/int1 pathway, a critical route in the pathogenesis of IPF. ...Silencing …
CD206(+) M2-like macrophages protect against intervertebral disc degeneration partially by targeting R-spondin-2.
Li XC, Wang W, Jiang C, Chen YL, Chen JH, Zhang ZW, Luo SJ, Chen RC, Mo PF, Zhong ML, Shi JY, Huang CM, Chen Q, Wu YH. Li XC, et al. Osteoarthritis Cartilage. 2024 Jan;32(1):66-81. doi: 10.1016/j.joca.2023.09.010. Epub 2023 Oct 4. Osteoarthritis Cartilage. 2024. PMID: 37802465
Finally, mice and NPCs were treated with R-spondin-2 (Rspo2) or anti-Rspo2 to investigate the role of Rspo2 in IDD. RESULTS: Accumulation of CD206 in human and mouse IDD tissues was detected. ...Hence, M2-polarized macrophages and Rspo …
Finally, mice and NPCs were treated with R-spondin-2 (Rspo2) or anti-Rspo2 to investigate the role of …
RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. Sun R, et al. Cell Rep. 2021 Aug 17;36(7):109559. doi: 10.1016/j.celrep.2021.109559. Cell Rep. 2021. PMID: 34407399 Free article.
Here, we show that AML cells secrete the stem cell growth factor R-spondin 2 (RSPO2) to promote their self-renewal and prevent cell differentiation. ...Comprehensive datamining reveals that RSPO2 expression is elevated in patients with AML of po …
Here, we show that AML cells secrete the stem cell growth factor R-spondin 2 (RSPO2) to promote their self-renew …
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/beta-catenin pathway.
Guo D, Pan H, Lu X, Chen Z, Zhou L, Chen S, Huang J, Liang X, Xiao Z, Zeng H, Shao Y, Qi W, Xie D, Lin C. Guo D, et al. Arthritis Res Ther. 2023 Nov 9;25(1):217. doi: 10.1186/s13075-023-03198-1. Arthritis Res Ther. 2023. PMID: 37946278 Free PMC article.
Recent research has shed light on the crucial regulatory role of R-spondin-2 (Rspo2) in cellular proliferation, cartilage degradation, and tumorigenesis. ...Recombinant mouse Rspo2 (rmRspo2), Rspo2 neutralizing antibody (Rspo2-NAb) …
Recent research has shed light on the crucial regulatory role of R-spondin-2 (Rspo2) in cellular proliferation, …
R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.
Nakashima H, Ohkawara B, Ishigaki S, Fukudome T, Ito K, Tsushima M, Konishi H, Okuno T, Yoshimura T, Ito M, Masuda A, Sobue G, Kiyama H, Ishiguro N, Ohno K. Nakashima H, et al. Sci Rep. 2016 Jun 22;6:28512. doi: 10.1038/srep28512. Sci Rep. 2016. PMID: 27328992 Free PMC article.
Laser capture microdissection of SMNs revealed that a secreted activator of Wnt signaling, R-spondin 2 (Rspo2), is highly expressed in SMNs. We found that Rspo2 is enriched at the NMJ, and that Rspo2 induces MuSK phosphorylation and AChR …
Laser capture microdissection of SMNs revealed that a secreted activator of Wnt signaling, R-spondin 2 (Rspo2), …
R-spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/beta-catenin signaling pathway.
Arima M, Hasegawa D, Yoshida S, Mitarai H, Tomokiyo A, Hamano S, Sugii H, Wada N, Maeda H. Arima M, et al. J Periodontal Res. 2019 Apr;54(2):143-153. doi: 10.1111/jre.12611. Epub 2018 Oct 4. J Periodontal Res. 2019. PMID: 30284717 Free article.
OBJECTIVE: In this study, we measured the expression of R-spondin 2 (RSPO2) in periodontal ligament (PDL) tissue and cells. Further, we examined the effects of RSPO2 on osteoblastic differentiation of immature human PDL cells (HPDLCs). ...RESULT …
OBJECTIVE: In this study, we measured the expression of R-spondin 2 (RSPO2) in periodontal ligament (PDL) tissue …
30 results