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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1992 1
1993 1
1994 1
1995 1
1996 5
1997 4
1998 2
1999 3
2000 3
2001 2
2002 2
2003 1
2004 1
2005 4
2006 1
2007 3
2008 5
2009 4
2010 3
2011 3
2012 3
2013 3
2014 1
2015 2
2016 2
2017 14
2018 10
2019 9
2020 5
2021 5
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98 results
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Page 1
Modern management of perianal fistulas in Crohn's disease: future directions.
Kotze PG, Shen B, Lightner A, Yamamoto T, Spinelli A, Ghosh S, Panaccione R. Kotze PG, et al. Gut. 2018 Jun;67(6):1181-1194. doi: 10.1136/gutjnl-2017-314918. Epub 2018 Jan 13. Gut. 2018. PMID: 29331943 Review.
Despite the introduction of new medical therapies such as antitumour necrosis factor and novel models of care delivery, the best fistula healing rates reported with combined medical and surgical approaches are approximately 50%. ...
Despite the introduction of new medical therapies such as antitumour necrosis factor and novel models of care delivery, the best fistula
Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease.
Dietz AB, Dozois EJ, Fletcher JG, Butler GW, Radel D, Lightner AL, Dave M, Friton J, Nair A, Camilleri ET, Dudakovic A, van Wijnen AJ, Faubion WA. Dietz AB, et al. Gastroenterology. 2017 Jul;153(1):59-62.e2. doi: 10.1053/j.gastro.2017.04.001. Epub 2017 Apr 9. Gastroenterology. 2017. PMID: 28400193 Free PMC article. Clinical Trial.
We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or …
We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, …
Interdisciplinary Management of Perianal Crohn's Disease.
Lightner AL, Faubion WA, Fletcher JG. Lightner AL, et al. Gastroenterol Clin North Am. 2017 Sep;46(3):547-562. doi: 10.1016/j.gtc.2017.05.008. Gastroenterol Clin North Am. 2017. PMID: 28838414 Review.
Cell-based Therapy for Perianal Fistulising Crohn's Disease.
Kotze PG, Spinelli A, Lightner AL. Kotze PG, et al. Curr Pharm Des. 2019;25(1):41-46. doi: 10.2174/1381612825666190308095651. Curr Pharm Des. 2019. PMID: 31092172 Review.
A multidisciplinary approach with optimized medical therapy, usually anti-TNF agents, associated with setons and additional surgical techniques is currently the best strategy to aim fistula healing. METHODS: A comprehensive review of the literature was conducted on the use …
A multidisciplinary approach with optimized medical therapy, usually anti-TNF agents, associated with setons and additional surgical techniq …
MR Imaging of Perianal Crohn Disease.
Sheedy SP, Bruining DH, Dozois EJ, Faubion WA, Fletcher JG. Sheedy SP, et al. Radiology. 2017 Mar;282(3):628-645. doi: 10.1148/radiol.2016151491. Radiology. 2017. PMID: 28218881 Review.
Perianal fistulas are a leading cause of patient morbidity because closure often requires multimodality treatments over a prolonged period of time. This review summarizes clinically relevant anal sphincter anatomy, imaging methods, classification systems, and treatment obj …
Perianal fistulas are a leading cause of patient morbidity because closure often requires multimodality treatments over a prolonged period o …
Imaging and Surgical Management of Anorectal Vaginal Fistulas.
VanBuren WM, Lightner AL, Kim ST, Sheedy SP, Woolever MC, Menias CO, Fletcher JG. VanBuren WM, et al. Radiographics. 2018 Sep-Oct;38(5):1385-1401. doi: 10.1148/rg.2018170167. Radiographics. 2018. PMID: 30207932 Review.
Surgical management is heavily dependent on the cause and complexity of the fistulizing disease, which are related to the location of the fistula in the vagina, the type and extent of fistula branching, the number of fistulas, sphincter tears, inflammation, and absc …
Surgical management is heavily dependent on the cause and complexity of the fistulizing disease, which are related to the location of the …
Matrix-Delivered Autologous Mesenchymal Stem Cell Therapy for Refractory Rectovaginal Crohn's Fistulas.
Lightner AL, Dozois EJ, Dietz AB, Fletcher JG, Friton J, Butler G, Faubion WA. Lightner AL, et al. Inflamm Bowel Dis. 2020 Apr 11;26(5):670-677. doi: 10.1093/ibd/izz215. Inflamm Bowel Dis. 2020. PMID: 31605115 Clinical Trial.
At 6 months, 3 patients had complete cessation of drainage, and 2 had >50% reduction in drainage; all had a persistent fistula tract identified on magnetic resonance imaging and EUA at 6 months. CONCLUSIONS: Surgical placement of an autologous adipose-derived MSC-coated …
At 6 months, 3 patients had complete cessation of drainage, and 2 had >50% reduction in drainage; all had a persistent fistula tra …
Outcomes of Rectovaginal Fistula Repair.
Byrnes JN, Schmitt JJ, Faustich BM, Mara KC, Weaver AL, Chua HK, Occhino JA. Byrnes JN, et al. Female Pelvic Med Reconstr Surg. 2017 Mar/Apr;23(2):124-130. doi: 10.1097/SPV.0000000000000373. Female Pelvic Med Reconstr Surg. 2017. PMID: 28106653
The most common fistula etiology was RVF-I (54.2%), followed by RVF-O (23.4%), and RVF-C (22.4%). ...CONCLUSIONS: Recurrence rates after RVF repair are high and did not differ by fistula etiology. Abdominal repair of RVF had significantly fewer recurrences....
The most common fistula etiology was RVF-I (54.2%), followed by RVF-O (23.4%), and RVF-C (22.4%). ...CONCLUSIONS: Recurrence rates af …
Update on the Natural Course of Fistulizing Perianal Crohn's Disease in a Population-Based Cohort.
Park SH, Aniwan S, Scott Harmsen W, Tremaine WJ, Lightner AL, Faubion WA, Loftus EV. Park SH, et al. Inflamm Bowel Dis. 2019 May 4;25(6):1054-1060. doi: 10.1093/ibd/izy329. Inflamm Bowel Dis. 2019. PMID: 30346531 Free PMC article.
The cumulative incidence of perianal or rectovaginal fistulas from time of CD diagnosis and the cumulative rate of proctectomy from date of first perianal or rectovaginal fistula diagnosis were estimated using the Kaplan-Meier method. RESULTS: Eighty-five patients (20.5%) …
The cumulative incidence of perianal or rectovaginal fistulas from time of CD diagnosis and the cumulative rate of proctectomy from date of …
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