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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1955 1
1958 1
1964 2
1965 1
1966 3
1967 5
1968 5
1969 4
1970 5
1971 1
1972 6
1973 13
1974 14
1975 13
1976 21
1977 8
1978 11
1979 12
1980 5
1981 7
1982 13
1983 12
1984 12
1985 14
1986 13
1987 11
1988 14
1989 18
1990 32
1991 24
1992 19
1993 22
1994 23
1995 33
1996 33
1997 40
1998 44
1999 39
2000 49
2001 49
2002 68
2003 56
2004 63
2005 74
2006 81
2007 68
2008 80
2009 102
2010 123
2011 121
2012 106
2013 130
2014 124
2015 160
2016 177
2017 176
2018 208
2019 291
2020 349
2021 162
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3,053 results
Results by year
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Page 1
Gene Therapy.
High KA, Roncarolo MG. High KA, et al. N Engl J Med. 2019 Aug 1;381(5):455-464. doi: 10.1056/NEJMra1706910. N Engl J Med. 2019. PMID: 31365802 Review. No abstract available.
Rheumatoid Arthritis.
Sparks JA. Sparks JA. Ann Intern Med. 2019 Jan 1;170(1):ITC1-ITC16. doi: 10.7326/AITC201901010. Ann Intern Med. 2019. PMID: 30596879 Review.
In recent years, early diagnosis, aggressive treatment, and expanded therapeutic options of disease-modifying antirheumatic drugs have markedly improved both the management and long-term prognosis of RA....
In recent years, early diagnosis, aggressive treatment, and expanded therapeutic options of disease-modifying antirheumatic drugs hav …
Entering the Modern Era of Gene Therapy.
Anguela XM, High KA. Anguela XM, et al. Annu Rev Med. 2019 Jan 27;70:273-288. doi: 10.1146/annurev-med-012017-043332. Epub 2018 Nov 26. Annu Rev Med. 2019. PMID: 30477394 Review.
Gene therapy comes of age.
Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M. Dunbar CE, et al. Science. 2018 Jan 12;359(6372):eaan4672. doi: 10.1126/science.aan4672. Science. 2018. PMID: 29326244 Review.
After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic armamentarium for a variety of inherited and acquired human diseases. ...
After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic ar …
The effect of SPARK on social and motor skills of children with autism.
Najafabadi MG, Sheikh M, Hemayattalab R, Memari AH, Aderyani MR, Hafizi S. Najafabadi MG, et al. Pediatr Neonatol. 2018 Oct;59(5):481-487. doi: 10.1016/j.pedneo.2017.12.005. Epub 2018 Jan 6. Pediatr Neonatol. 2018. PMID: 29402579 Free article.
BACKGROUND: This study aimed to evaluate the effectiveness of a selected group exercise known as Sports, Play and Active Recreation for Kids (SPARK) on the motor and behavioral skills of children with autism spectrum disorder (ASD) using a quasi-experimental design with re …
BACKGROUND: This study aimed to evaluate the effectiveness of a selected group exercise known as Sports, Play and Active Recreation for Kids …
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial.
Russell S, Bennett J, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, McCague S, Cross D, Marshall KA, Walshire J, Kehoe TL, Reichert H, Davis M, Raffini L, George LA, Hudson FP, Dingfield L, Zhu X, Haller JA, Sohn EH, Mahajan VB, Pfeifer W, Weckmann M, Johnson C, Gewaily D, Drack A, Stone E, Wachtel K, Simonelli F, Leroy BP, Wright JF, High KA, Maguire AM. Russell S, et al. Lancet. 2017 Aug 26;390(10097):849-860. doi: 10.1016/S0140-6736(17)31868-8. Epub 2017 Jul 14. Lancet. 2017. PMID: 28712537 Free PMC article. Clinical Trial.
INTERPRETATION: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreatable. FUNDING: Spark Therapeutics....
INTERPRETATION: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously m …
Engineered nanoparticles for drug delivery in cancer therapy.
Sun T, Zhang YS, Pang B, Hyun DC, Yang M, Xia Y. Sun T, et al. Angew Chem Int Ed Engl. 2014 Nov 10;53(46):12320-64. doi: 10.1002/anie.201403036. Epub 2014 Oct 7. Angew Chem Int Ed Engl. 2014. PMID: 25294565 Review.
In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack of targeting capability, …
In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a number of issues associated with convent …
Gene Therapy for Pompe Disease: The Time is now.
Colella P, Mingozzi F. Colella P, et al. Hum Gene Ther. 2019 Oct;30(10):1245-1262. doi: 10.1089/hum.2019.109. Epub 2019 Sep 9. Hum Gene Ther. 2019. PMID: 31298581 Review.
Based on emerging safety and efficacy data from clinical trials for other protein deficiencies, in vivo gene therapy with AAV vectors appears to have the potential to provide a therapeutically relevant, stable source of GAA enzyme, which could be highly beneficial in PD... …
Based on emerging safety and efficacy data from clinical trials for other protein deficiencies, in vivo gene therapy with AAV vectors appear …
Human Immune Responses to Adeno-Associated Virus (AAV) Vectors.
Ronzitti G, Gross DA, Mingozzi F. Ronzitti G, et al. Front Immunol. 2020 Apr 17;11:670. doi: 10.3389/fimmu.2020.00670. eCollection 2020. Front Immunol. 2020. PMID: 32362898 Free PMC article. Review.
Data gathered from clinical trials offers key learnings on the immunogenicity of AAV vectors, highlighting challenges as well as the potential strategies that could help unlock the full therapeutic potential of in vivo gene transfer....
Data gathered from clinical trials offers key learnings on the immunogenicity of AAV vectors, highlighting challenges as well as the potenti …
3,053 results
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