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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 2
2003 1
2004 1
2005 2
2006 2
2007 1
2008 1
2009 1
2011 5
2012 1
2013 3
2014 2
2015 5
2017 1
2018 2
2019 4
2020 2
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35 results
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Page 1
Microtubules in cell migration.
Garcin C, Straube A. Garcin C, et al. Essays Biochem. 2019 Oct 31;63(5):509-520. doi: 10.1042/EBC20190016. Essays Biochem. 2019. PMID: 31358621 Free PMC article. Review.
Microtubules act as force generators and compressive elements to support sustained cell protrusions. The assembly and disassembly of microtubules is coupled to Rho GTPase signalling, thereby controlling actin polymerisation, myosin-driven contractility and the turno
Microtubules act as force generators and compressive elements to support sustained cell protrusions. The assembly and disassembly of
Measuring microtubule dynamics.
Zwetsloot AJ, Tut G, Straube A. Zwetsloot AJ, et al. Essays Biochem. 2018 Dec 7;62(6):725-735. doi: 10.1042/EBC20180035. Print 2018 Dec 7. Essays Biochem. 2018. PMID: 30287587 Free PMC article. Review.
To do this, eukaryotic cells employ an arsenal of regulatory proteins to control microtubule dynamics spatially and temporally. ...Here, we summarize the methods used to visualize microtubules and to measure the parameters of dynamic instability to study both mic
To do this, eukaryotic cells employ an arsenal of regulatory proteins to control microtubule dynamics spatially and temporally. ...He …
Intracellular Cargo Transport by Kinesin-3 Motors.
Siddiqui N, Straube A. Siddiqui N, et al. Biochemistry (Mosc). 2017 Jul;82(7):803-815. doi: 10.1134/S0006297917070057. Biochemistry (Mosc). 2017. PMID: 28918744 Free article. Review.
Intracellular transport along microtubules enables cellular cargoes to efficiently reach the extremities of large, eukaryotic cells. ...The human genome encodes 45 kinesins, 8 of those belonging to the family of kinesin-3 organelle transporters that are known to transport …
Intracellular transport along microtubules enables cellular cargoes to efficiently reach the extremities of large, eukaryotic cells. …
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
Siddiqui N, Zwetsloot AJ, Bachmann A, Roth D, Hussain H, Brandt J, Kaverina I, Straube A. Siddiqui N, et al. Nat Commun. 2019 Jun 19;10(1):2693. doi: 10.1038/s41467-019-10644-9. Nat Commun. 2019. PMID: 31217419 Free PMC article.
We show that the microtubule binding surface of KIF1C motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase PTPN21. ...Its landing rate onto microtubules increases in the presence o …
We show that the microtubule binding surface of KIF1C motor domain interacts with its stalk and that these autoinhibitory interaction …
Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM. Adib R, et al. Sci Signal. 2019 Aug 13;12(594):eaaw2939. doi: 10.1126/scisignal.aaw2939. Sci Signal. 2019. PMID: 31409757 Free article.
EML4 is a microtubule-associated protein that promotes microtubule stability. We investigated its regulation across the cell cycle and found that EML4 was distributed as punctate foci along the microtubule lattice in interphase but exhibited reduced associati …
EML4 is a microtubule-associated protein that promotes microtubule stability. We investigated its regulation across the cell c …
Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment.
Rushworth LK, Hewit K, Munnings-Tomes S, Somani S, James D, Shanks E, Dufès C, Straube A, Patel R, Leung HY. Rushworth LK, et al. Br J Cancer. 2020 Feb;122(4):517-527. doi: 10.1038/s41416-019-0681-5. Epub 2019 Dec 17. Br J Cancer. 2020. PMID: 31844184 Free PMC article.
RESULTS: Mebendazole (an anthelmintic drug that inhibits microtubule assembly) was selected as the lead drug and shown to potently synergise docetaxel-mediated cell killing in vitro and in vivo. ...CONCLUSIONS: Docetaxel and mebendazole target distinct aspects of the mi
RESULTS: Mebendazole (an anthelmintic drug that inhibits microtubule assembly) was selected as the lead drug and shown to potently sy …
Kinesins in cell migration.
Bachmann A, Straube A. Bachmann A, et al. Biochem Soc Trans. 2015 Feb;43(1):79-83. doi: 10.1042/BST20140280. Biochem Soc Trans. 2015. PMID: 25619249 Review.
Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtub
Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesi …
Spatial positioning of EB family proteins at microtubule tips involves distinct nucleotide-dependent binding properties.
Roth D, Fitton BP, Chmel NP, Wasiluk N, Straube A. Roth D, et al. J Cell Sci. 2018 Oct 31;132(4):jcs219550. doi: 10.1242/jcs.219550. J Cell Sci. 2018. PMID: 30262468 Free PMC article.
EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly and by acting as the hub of the tip-tracking network. ...However, the three signals differ in their maxima and position from the microtubule tip. Using micro
EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly and by acting as the hub of …
A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation.
Mogessie B, Roth D, Rahil Z, Straube A. Mogessie B, et al. Elife. 2015 Apr 21;4:e05697. doi: 10.7554/eLife.05697. Elife. 2015. PMID: 25898002 Free PMC article.
The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation. ...Purified oMAP4 aligns dynamic microtubules into anti …
The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial mi
Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ. Hood FE, et al. J Cell Biol. 2013 Aug 5;202(3):463-78. doi: 10.1083/jcb.201211127. J Cell Biol. 2013. PMID: 23918938 Free PMC article.
It is unclear how this complex binds microtubules and how the proteins in the complex interact with one another. TACC3 and clathrin have each been proposed to be the spindle recruitment factor. ...The N-terminal domain of clathrin and the TACC domain of TACC3 in tandem mad …
It is unclear how this complex binds microtubules and how the proteins in the complex interact with one another. TACC3 and clathrin h …
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