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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 2
1981 1
1982 1
1986 1
1987 2
1989 1
1991 1
1992 1
1995 1
1997 1
1999 2
2000 2
2001 3
2002 3
2004 4
2005 3
2006 3
2007 4
2008 7
2009 4
2010 4
2011 7
2012 5
2013 5
2014 7
2015 7
2016 6
2017 9
2018 12
2019 14
2020 24
2021 16
2022 17
2023 10
2024 3

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160 results

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Page 1
Pigmented villonodular synovitis/giant cell tumor in the knee.
Chipman DE, Perkins CA, Lijesen E, Green DW. Chipman DE, et al. Curr Opin Pediatr. 2024 Feb 1;36(1):78-82. doi: 10.1097/MOP.0000000000001312. Epub 2023 Nov 23. Curr Opin Pediatr. 2024. PMID: 37994651 Review.
Early diagnosis is important to prevent secondary degeneration into the subchondral bone. This review will analyze the etiology, clinical signs/symptoms, diagnosis, treatment, and recent literature on PVNS in the pediatric population. ...
Early diagnosis is important to prevent secondary degeneration into the subchondral bone. This review will analyze the etiology, clinical
Real-World Patient Experience of Pexidartinib for Tenosynovial Giant-Cell Tumor.
Lin F, Jacqueline Kwong W, Pan I, Ye X, Dai D, Tap W. Lin F, et al. Oncologist. 2024 Apr 4;29(4):e535-e543. doi: 10.1093/oncolo/oyad282. Oncologist. 2024. PMID: 37874926 Free PMC article.
BACKGROUND: Pexidartinib (Turalio) is the only systemic therapy approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant-cell tumor (TGCT) associated with severe morbidity or functional limitations, and not amenable t …
BACKGROUND: Pexidartinib (Turalio) is the only systemic therapy approved by the FDA for the treatment of adult patients with symptomatic …
Supporting patients in the transition to the revised pexidartinib dosing regimen: perspectives from the multidisciplinary clinical and allied health professional team.
McCabe C, Wright H, Polson K, Wagner AJ. McCabe C, et al. Orphanet J Rare Dis. 2023 Oct 7;18(1):313. doi: 10.1186/s13023-023-02926-9. Orphanet J Rare Dis. 2023. PMID: 37805596 Free PMC article.
Pexidartinib is a colony-stimulating factor-1 receptor inhibitor approved in the United States for treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amen …
Pexidartinib is a colony-stimulating factor-1 receptor inhibitor approved in the United States for treatment of adult patients with symptoma …
The MOTION study: a randomized, phase III study of vimseltinib for the treatment of tenosynovial giant cell tumor.
Tap WD, Sharma MG, Vallee M, Smith BD, Sherman ML, Ruiz-Soto R, de Sande MV, Randall RL, Bernthal NM, Gelderblom H. Tap WD, et al. Future Oncol. 2024 Mar;20(10):593-601. doi: 10.2217/fon-2023-0238. Epub 2023 Aug 18. Future Oncol. 2024. PMID: 37593881 Free article.
Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm that occurs in the synovium of joints, bursae, or tendon sheaths and is caused by upregulation of the CSF1 gene. ...Part 2 is a long-term treatment phase in which partic
Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm that occurs in the synovium of joint
Updates on the Treatment of Tenosynovial Giant Cell Tumor.
Chan AS, Katiyar V, Dy P, Singh V. Chan AS, et al. Hematol Oncol Stem Cell Ther. 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. Hematol Oncol Stem Cell Ther. 2023. PMID: 37363972 Review.
Tenosynovial giant cell tumor (TGCT) is a rare inflammatory disorder affecting the joint synovium, bursae, and tendon sheaths that causes non-specific and often insidious joint discomfort. ...
Tenosynovial giant cell tumor (TGCT) is a rare inflammatory disorder affecting the joint synovium, bursae, and
Total Hip Arthroplasty or Arthroscopy for Pigmented Villonodular Synovitis of the Hip: A Retrospective Study with 3-Year Follow-Up at Minimum.
Li T, Mei L, Xu Y, Cao Y, Shi X, Chen G, Li J. Li T, et al. Orthop Surg. 2023 Jun;15(6):1498-1504. doi: 10.1111/os.13707. Epub 2023 Apr 24. Orthop Surg. 2023. PMID: 37092432 Free PMC article.
METHODS: This was a retrospective clinical trial with data from patients with pigment Villonodular synovitis of the hip between 2010 and 2019. ...The clinical efficacy was measured using the Harris hip scores (HHSs) and visual analogue scale (VAS) score. ...
METHODS: This was a retrospective clinical trial with data from patients with pigment Villonodular synovitis of the hip betwee …
Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model-informed Drug Development Strategy.
Zahir H, Yin O, Hsu C, Wagner AJ, Jiang J, Wang X, Greenberg J, Shuster DE, Kakkar T, LaCreta F. Zahir H, et al. Clin Pharmacol Drug Dev. 2023 May;12(5):475-483. doi: 10.1002/cpdd.1240. Epub 2023 Mar 21. Clin Pharmacol Drug Dev. 2023. PMID: 36942508
Pexidartinib, an oral small molecule inhibitor of the colony-stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable t …
Pexidartinib, an oral small molecule inhibitor of the colony-stimulating factor 1 receptor, is approved for treatment of adults with symptom …
Exploration of comorbidity mechanisms and potential therapeutic targets of rheumatoid arthritis and pigmented villonodular synovitis using machine learning and bioinformatics analysis.
Heng H, Li D, Su W, Liu X, Yu D, Bian Z, Li J. Heng H, et al. Front Genet. 2023 Jan 6;13:1095058. doi: 10.3389/fgene.2022.1095058. eCollection 2022. Front Genet. 2023. PMID: 36685864 Free PMC article.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease. Pigmented villonodular synovitis (PVNS) is a tenosynovial giant cell tumor that can involve joints. The mechanisms of co-morbidity between the two diseases have not been thoroughly …
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease. Pigmented villonodular synovitis (PVNS) is a tenosynovial g
CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D. Wen J, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114884. doi: 10.1016/j.ejmech.2022.114884. Epub 2022 Oct 29. Eur J Med Chem. 2023. PMID: 36335744 Review.
Activation of CSF1R by endogenous cytokine ligation to the ectodomain triggers the autophosphorylation of the intracellular tyrosine kinase domain, and thereafter, activation of several downstream pro-survival kinase cascades, including PI3K, ERK1/2, and JNK. The immunological ro …
Activation of CSF1R by endogenous cytokine ligation to the ectodomain triggers the autophosphorylation of the intracellular tyrosine kinase …
Evaluation of Absorption and Metabolism-Based DDI Potential of Pexidartinib in Healthy Subjects.
Zahir H, Greenberg J, Shuster D, Hsu C, Watanabe K, LaCreta F. Zahir H, et al. Clin Pharmacokinet. 2022 Nov;61(11):1623-1639. doi: 10.1007/s40262-022-01172-9. Epub 2022 Oct 20. Clin Pharmacokinet. 2022. PMID: 36264536 Free PMC article. Clinical Trial.
It is approved in the United States for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery. ...These results prov …
It is approved in the United States for the treatment of adult patients with symptomatic tenosynovial giant cell tum
160 results