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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1952 3
1953 4
1954 6
1955 1
1956 4
1957 5
1958 4
1959 2
1963 1
1964 2
1965 8
1966 12
1967 34
1968 33
1969 46
1970 41
1971 49
1972 60
1973 67
1974 73
1975 80
1976 91
1977 103
1978 114
1979 113
1980 129
1981 146
1982 175
1983 169
1984 189
1985 196
1986 224
1987 193
1988 205
1989 238
1990 308
1991 309
1992 331
1993 353
1994 416
1995 459
1996 447
1997 478
1998 518
1999 556
2000 604
2001 620
2002 634
2003 752
2004 811
2005 947
2006 993
2007 1054
2008 1120
2009 1115
2010 1198
2011 1221
2012 1316
2013 1389
2014 1461
2015 1412
2016 1351
2017 1403
2018 1407
2019 947
2020 118
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Search Results

26,585 results
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Page 1
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, et al. J Altern Complement Med 2017 - Review. PMID 28112552 Free PMC article.
OBJECTIVES: Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupuncture use and research, little remains known about its effects on nerve function. ...CONCLUSIONS: Acupuncture is beneficial in some peripheral neuropathies, but more rigorously designed studies using sham-acupuncture control are needed to characterize its effect and optimal use better....
OBJECTIVES: Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupu …
A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice.
Aiyer R, et al. Clin J Pain 2018. PMID 28877137
Dextromethorphan and valproic acid both had 4 randomized controlled trials that showed some NeuP treatment benefit while carbamazepine had over 8 trials showing efficacy. Finally, phenytoin only had 1 trial that showed clinical response in treatment. CONCLUSIONS: There are a variety of NMDAR antagonist agents that should be considered for treatment of NeuP. ...
Dextromethorphan and valproic acid both had 4 randomized controlled trials that showed some NeuP treatment benefit while carba …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala , et al. Neurosci Biobehav Rev 2015 - Review. PMID 25957927 Free article.
In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. ...Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable....
In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particular …
Design and Rationale of the Phase 3 ATTR-ACT Clinical Trial (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial).
Maurer MS, et al. Circ Heart Fail 2017 - Review. PMID 28611125
The design and rationale behind the ongoing phase 3 ATTR-ACT study (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial), an international, multicenter, double-blind, placebo-controlled, randomized clinical trial, is also outlined. ...CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01994889....
The design and rationale behind the ongoing phase 3 ATTR-ACT study (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial), …
Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations.
Gewandter JS, et al. Neurology 2018 - Review. PMID 30054438 Free PMC article.
The small number of positive randomized clinical trials (RCTs) evaluating preventive therapies for CIPN provide little guidance to inform the design of future trials. ...An Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities and Networks (ACTTION)-Consortium on Clinical Endpoints and Procedures for Peripheral Neuropathy Trials (CONCEPPT) meeting attended by neurologists, oncologists, pharmacists, clinical trialists, statisticians, and regulatory experts was convened to discuss design considerations and provide recommendations for CIPN prevention trials. ...
The small number of positive randomized clinical trials (RCTs) evaluating preventive therapies for CIPN provide little …
An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics
Wang Z, et al. Biosci Trends 2018 - Review. PMID 30012913 Free article.
Second, some clinical trials using Chinese herbal medicines as adjuvant improving cancer treatment related side effects and complications are reviewed. ...However, rigorously designed trials on potential Chinese herbal medicine must be further examined involving cancer treatment especially molecular targeted-therapy in the future....
Second, some clinical trials using Chinese herbal medicines as adjuvant improving cancer treatment related side effects and co …
New Practical Approaches to Chemotherapy-Induced Neuropathic Pain: Prevention, Assessment, and Treatment
Majithia N, et al. Oncology (Williston Park) 2016 - Review. PMID 27854104 Free article.
There is good randomized trial evidence that most of the anticonvulsants and tricyclic antidepressants typically prescribed for neuropathic pain have little or no effect on CIPN, but there is some evidence of efficacy for duloxetine-however, clinical practice with regard to pharmacologic treatment of CIPN often does not reflect these data. We review here the recommendations of the American Society of Clinical Oncology, as well as some new and promising approaches to neuropathy, including new neuromodulation techniques....
There is good randomized trial evidence that most of the anticonvulsants and tricyclic antidepressants typically prescribed fo …
Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review
Jiménez Del Barrio S, et al. Neurologia 2018. PMID 27461181 Free article.
BACKGROUND: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy. It is characterised by the compression of the median nerve in the carpal tunnel. ...We used the Medline, PEDro, and Cochrane databases to find and select randomised controlled clinical trials evaluating the effects of conservative treatment on the symptoms and functional ability of patients with mild to moderate CTS; 32 clinical trials were included. ...
BACKGROUND: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy. It is characterised by the compression of the medi …
Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.
Onakpoya IJ, et al. BMJ Open 2019 - Review. PMID 30670513 Free PMC article.
DESIGN: Rapid review and meta-analysis of phase III, randomised, placebo-controlled trials. PARTICIPANTS: Adults aged 18 years and above with neuropathic pain defined according to the International Association for the Study of Pain criteria. ...RESULTS: We included 28 trials comprising 6087 participants. The neuropathic pain conditions studied were diabetic peripheral neuropathy, postherpetic neuralgia, herpes zoster, sciatica (radicular pain), poststroke pain and spinal cord injury-related pain. ...
DESIGN: Rapid review and meta-analysis of phase III, randomised, placebo-controlled trials. PARTICIPANTS: Adults aged 18 years …
Bortezomib for the treatment of multiple myeloma
Scott K, et al. Cochrane Database Syst Rev 2016 - Review. PMID 27096326
SEARCH METHODS: We searched MEDLINE, the Cochrane Central Register of Controlled Trials and EMBASE (till 27 January 2016) as well as conference proceedings and clinical trial registries for randomised controlled trials (RCTs). ...We contacted trial authors to provide summary statistics if missing. We estimated Logrank statistics which were not available. ...
SEARCH METHODS: We searched MEDLINE, the Cochrane Central Register of Controlled Trials and EMBASE (till 27 January 2016) as well as …
26,585 results
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