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Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells.
van der Mark VA, Adam AAA, Chang JC, Oude Elferink RP, Chamuleau RAFM, Hoekstra R. van der Mark VA, et al. Toxicol Appl Pharmacol. 2020 Jul 15;399:115055. doi: 10.1016/j.taap.2020.115055. Epub 2020 May 16. Toxicol Appl Pharmacol. 2020. PMID: 32428594 Free article.
The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. ...We compared monolayer and BALIAD cultures of HepaRG and HepaRG-CAR cells. CAR overexpression and BALIAD culturing synergistically or additively incre …
The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. ...We compared monolayer a …
Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.
van der Mark VA, Rudi de Waart D, Shevchenko V, Elferink RP, Chamuleau RA, Hoekstra R. van der Mark VA, et al. Drug Metab Dispos. 2017 Jan;45(1):56-67. doi: 10.1124/dmd.116.072603. Epub 2016 Oct 25. Drug Metab Dispos. 2017. PMID: 27780834
Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG; however, DMSO also induces cell death and interferes with cellular activities. ...Transcript levels of CAR target genes were significantl …
Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG …