Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model.
Millecam J, van Bergen T, Schauvliege S, Antonissen G, Martens A, Chiers K, Gehring R, Gasthuys E, Vande Walle J, Croubels S, Devreese M.
Millecam J, et al. Among authors: van bergen t.
Front Pharmacol. 2019 May 9;10:505. doi: 10.3389/fphar.2019.00505. eCollection 2019.
Front Pharmacol. 2019.
PMID: 31143123
Free PMC article.
After the trial, necropsy and histology was performed to evaluate macroscopic and microscopic gastro-intestinal as well as renal lesions. Both enantiomers, R-ibuprofen and S-ibuprofen, were determined in plasma using an in-house developed and validated UHPLC-MS/MS method. …
After the trial, necropsy and histology was performed to evaluate macroscopic and microscopic gastro-intestinal as well as renal lesions. Bo …