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Page 1
Regulators of hepcidin expression.
Roth MP, Meynard D, Coppin H. Roth MP, et al. Among authors: coppin h. Vitam Horm. 2019;110:101-129. doi: 10.1016/bs.vh.2019.01.005. Epub 2019 Feb 2. Vitam Horm. 2019. PMID: 30798807 Review.
This regulation is mediated by the hepatic hormone hepcidin. Hepcidin also controls iron release from macrophages that recycle iron and from hepatocytes that store iron. ...Dysregulation of hepcidin production contributes to the pathogenesis of many iron …
This regulation is mediated by the hepatic hormone hepcidin. Hepcidin also controls iron release from macrophages that recycle iro …
Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice.
Cavey T, Latour C, Island ML, Leroyer P, Guggenbuhl P, Coppin H, Roth MP, Bendavid C, Brissot P, Ropert M, Loréal O. Cavey T, et al. Among authors: coppin h. FASEB J. 2019 Oct;33(10):11072-11081. doi: 10.1096/fj.201801381RR. Epub 2019 Jul 23. FASEB J. 2019. PMID: 31298936 Free article.
Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron sequestration in the spleen. Genetic iron overload related to hepcidin insufficiency decreases the spleen iron concentration and in …
Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism regulator that favors iron seque …
Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.
Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H. Latour C, et al. Among authors: coppin h. Hepatology. 2016 Jan;63(1):126-37. doi: 10.1002/hep.28254. Epub 2015 Nov 12. Hepatology. 2016. PMID: 26406355
Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) ge …
Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, a …
Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers.
Coppin H, Darnaud V, Kautz L, Meynard D, Aubry M, Mosser J, Martinez M, Roth MP. Coppin H, et al. Genome Biol. 2007;8(10):R221. doi: 10.1186/gb-2007-8-10-r221. Genome Biol. 2007. PMID: 17945001 Free PMC article.
In liver, Hfe disruption upregulated genes involved in antioxidant defense, reflecting mechanisms of hepatoprotection activated by iron overload. Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and …
In liver, Hfe disruption upregulated genes involved in antioxidant defense, reflecting mechanisms of hepatoprotection activated by iron …
A human anti-matriptase-2 antibody limits iron overload, alpha-globin aggregates, and splenomegaly in beta-thalassemic mice.
Wake M, Palin A, Belot A, Berger M, Lorgouilloux M, Bichon M, Papworth J, Bayliss L, Grimshaw B, Rynkiewicz N, Paterson J, Poindron A, Spearing E, Carter E, Hudson R, Campbell M, Petzer V, Besson-Fournier C, Latour C, Largounez A, Gourbeyre O, Fay A, Coppin H, Roth MP, Theurl I, Germaschewski V, Meynard D. Wake M, et al. Among authors: coppin h. Blood Adv. 2024 Apr 23;8(8):1898-1907. doi: 10.1182/bloodadvances.2023012010. Blood Adv. 2024. PMID: 38241484 Free PMC article.
Iron plays a major role in the deterioration of beta-thalassemia. Indeed, the high levels of transferrin saturation and iron delivered to erythroid progenitors are associated with production of alpha-globin precipitates that negatively affect erythropoiesis. ...When …
Iron plays a major role in the deterioration of beta-thalassemia. Indeed, the high levels of transferrin saturation and iron d …
Targeting iron-mediated retinal degeneration by local delivery of transferrin.
Picard E, Le Rouzic Q, Oudar A, Berdugo M, El Sanharawi M, Andrieu-Soler C, Naud MC, Jonet L, Latour C, Klein C, Galiacy S, Malecaze F, Coppin H, Roth MP, Jeanny JC, Courtois Y, Behar-Cohen F. Picard E, et al. Among authors: coppin h. Free Radic Biol Med. 2015 Dec;89:1105-21. doi: 10.1016/j.freeradbiomed.2015.08.018. Epub 2015 Oct 8. Free Radic Biol Med. 2015. PMID: 26454080 Free article.
Iron retinal homeostasis is highly regulated and transferrin (Tf), a potent iron chelator, is endogenously secreted by retinal cells. ...We found an association between Tf treatment and the modulation of iron homeostasis resulting in a decrease of iron …
Iron retinal homeostasis is highly regulated and transferrin (Tf), a potent iron chelator, is endogenously secreted by retinal …
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice.
Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, Leroyer P, Coppin H, Brissot P, Roth MP, Loréal O. Courselaud B, et al. Among authors: coppin h. Blood Cells Mol Dis. 2004 Mar-Apr;32(2):283-9. doi: 10.1016/j.bcmd.2003.11.003. Blood Cells Mol Dis. 2004. PMID: 15003819
Hepcidin (HEPC) plays a key role in iron homeostasis and an abnormally low level of hepcidin mRNA has been reported in HFE-1 genetic hemochromatosis. Considering the well-known phenotypic variability of this disease, especially between men and women, it is important …
Hepcidin (HEPC) plays a key role in iron homeostasis and an abnormally low level of hepcidin mRNA has been reported in HFE-1 genetic …
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.
Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP. Kautz L, et al. Among authors: coppin h. Blood. 2008 Aug 15;112(4):1503-9. doi: 10.1182/blood-2008-03-143354. Epub 2008 Jun 6. Blood. 2008. PMID: 18539898 Free article.
Gene expression variations induced by secondary iron deficiency or iron overload were compared with those consecutive to Smad4 and Hamp1 deficiency. Iron overload developed by Smad4- and Hamp1-deficient mice also increased Bmp6 transcription. ...
Gene expression variations induced by secondary iron deficiency or iron overload were compared with those consecutive to Smad4 …
Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains.
Dupic F, Fruchon S, Bensaid M, Borot N, Radosavljevic M, Loreal O, Brissot P, Gilfillan S, Bahram S, Coppin H, Roth MP. Dupic F, et al. Among authors: coppin h. Gastroenterology. 2002 Mar;122(3):745-51. doi: 10.1053/gast.2002.31877. Gastroenterology. 2002. PMID: 11875007
BACKGROUND & AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorption and increased iron deposition in hepatic parenchymal cells. The goals of the present study were to gain further insight into the c …
BACKGROUND & AIMS: Hfe knockout mice, like patients with hereditary hemochromatosis, have augmented duodenal iron absorpti …
Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice.
Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N, Roth MP, Coppin H. Dupic F, et al. Among authors: coppin h. Gut. 2002 Nov;51(5):648-53. doi: 10.1136/gut.51.5.648. Gut. 2002. PMID: 12377801 Free PMC article.
This is of particular interest however as genetic factors are likely to determine differences in iron status among mouse strains and probably also contribute to the phenotypic variability seen with disruption of the haemochromatosis gene. ...RESULTS: There was a sig …
This is of particular interest however as genetic factors are likely to determine differences in iron status among mouse strains and …
36 results