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2020 2
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2022 1384
2023 9253
2024 58

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Page 1
Therapeutic strategies for COVID-19: progress and lessons learned.
Li G, Hilgenfeld R, Whitley R, De Clercq E. Li G, et al. Nat Rev Drug Discov. 2023 Jun;22(6):449-475. doi: 10.1038/s41573-023-00672-y. Epub 2023 Apr 19. Nat Rev Drug Discov. 2023. PMID: 37076602 Free PMC article. Review.
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic strategies that target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and/or human proteins to control viral infection, encompassing hundre …
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic strategies that targ …
Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses.
Morens DM, Taubenberger JK, Fauci AS. Morens DM, et al. Cell Host Microbe. 2023 Jan 11;31(1):146-157. doi: 10.1016/j.chom.2022.11.016. Cell Host Microbe. 2023. PMID: 36634620 Free PMC article. Review.
Viruses that replicate in the human respiratory mucosa without infecting systemically, including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other "common cold" viruses, cause significant mortality and morbidity and are important public health concerns. . …
Viruses that replicate in the human respiratory mucosa without infecting systemically, including influenza A, SARS-CoV-2, endemic coronav …
Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic.
Oudit GY, Wang K, Viveiros A, Kellner MJ, Penninger JM. Oudit GY, et al. Cell. 2023 Mar 2;186(5):906-922. doi: 10.1016/j.cell.2023.01.039. Epub 2023 Feb 2. Cell. 2023. PMID: 36787743 Free PMC article. Review.
ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to …
ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifest …
An overview on the treatments and prevention against COVID-19.
Panahi Y, Gorabi AM, Talaei S, Beiraghdar F, Akbarzadeh A, Tarhriz V, Mellatyar H. Panahi Y, et al. Virol J. 2023 Feb 8;20(1):23. doi: 10.1186/s12985-023-01973-9. Virol J. 2023. PMID: 36755327 Free PMC article. Review.
BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. ...
BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS …
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity.
Aguilar-Bretones M, Fouchier RA, Koopmans MP, van Nierop GP. Aguilar-Bretones M, et al. J Clin Invest. 2023 Jan 3;133(1):e162192. doi: 10.1172/JCI162192. J Clin Invest. 2023. PMID: 36594464 Free PMC article. Review.
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19). This immunity may further be shaped by cross-reactivity with c …
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer p …
A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry.
Chen J, Yang X, Si H, Gong Q, Que T, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X, Tong Y, Hu Y, Shi ZL, Zhou P. Chen J, et al. Cell. 2023 Feb 16;186(4):850-863.e16. doi: 10.1016/j.cell.2023.01.019. Cell. 2023. PMID: 36803605 Free PMC article.
It is unknown whether pangolins, the most trafficked mammals, play a role in the zoonotic transmission of bat coronaviruses. We report the circulation of a novel MERS-like coronavirus in Malayan pangolins, named Manis javanica HKU4-related coronavirus …
It is unknown whether pangolins, the most trafficked mammals, play a role in the zoonotic transmission of bat coronaviruses. We repor …
Equine Coronaviruses.
Pusterla N. Pusterla N. Vet Clin North Am Equine Pract. 2023 Apr;39(1):55-71. doi: 10.1016/j.cveq.2022.11.008. Epub 2022 Nov 21. Vet Clin North Am Equine Pract. 2023. PMID: 36737293 Review.
Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In equids, equine coronavirus has been associated with diarrhea in foals and lethargy, fever, anorexia, and occasional gastrointestinal signs in adult horses. ...
Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In equids, equine coronavirus has b …
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors.
Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H. Xiong Q, et al. Nature. 2022 Dec;612(7941):748-757. doi: 10.1038/s41586-022-05513-3. Epub 2022 Dec 7. Nature. 2022. PMID: 36477529 Free PMC article.
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor(1-4). ...Cryo-electron microscopy analysis revealed an RBD-ACE2 binding interface involving protein-glycan interactions, dist …
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an …
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Zhou P, et al. Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16. Immunity. 2023. PMID: 36889306 Free PMC article.
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coronaviruses and to more effectively respond to SARS-CoV-2 variants. ...
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coro …
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein.
Bianchini F, Crivelli V, Abernathy ME, Guerra C, Palus M, Muri J, Marcotte H, Piralla A, Pedotti M, De Gasparo R, Simonelli L, Matkovic M, Toscano C, Biggiogero M, Calvaruso V, Svoboda P, Cervantes Rincón T, Fava T, Podešvová L, Shanbhag AA, Celoria A, Sgrignani J, Stefanik M, Hönig V, Pranclova V, Michalcikova T, Prochazka J, Guerrini G, Mehn D, Ciabattini A, Abolhassani H, Jarrossay D, Uguccioni M, Medaglini D, Pan-Hammarström Q, Calzolai L, Fernandez D, Baldanti F, Franzetti-Pellanda A, Garzoni C, Sedlacek R, Ruzek D, Varani L, Cavalli A, Barnes CO, Robbiani DF. Bianchini F, et al. Sci Immunol. 2023 Mar 17;8(81):eade0958. doi: 10.1126/sciimmunol.ade0958. Epub 2023 Mar 10. Sci Immunol. 2023. PMID: 36701425 Free PMC article.
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. ...Antibody fp.006 binds the fusion peptide and cross-reacts against coronaviruses of the four genera, includi …
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants diminishes the efficacy of vaccines and antiviral …
10,088 results
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