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Covid-19 and the Digestive System.
Wong SH, Lui RN, Sung JJ. Wong SH, et al. J Gastroenterol Hepatol. 2020 Mar 25. doi: 10.1111/jgh.15047. Online ahead of print. J Gastroenterol Hepatol. 2020. PMID: 32215956 Review.
The novel coronavirus disease (Covid-19) is currently causing a major pandemic. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Betacoronavirus genus that also includes the SARS-CoV and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). ...These suggest that SARS-CoV-2 can actively infect and replicate in the gastrointestinal tract. This has important implications to the disease management, transmission, and infection control. ...
The novel coronavirus disease (Covid-19) is currently causing a major pandemic. It is caused by the severe ac
Coronavirus Disease 2019 in Geriatrics and Long-term Care: The ABCDs of COVID-19.
D'Adamo H, Yoshikawa T, Ouslander JG. D'Adamo H, et al. J Am Geriatr Soc. 2020 Mar 25. doi: 10.1111/jgs.16445. Online ahead of print. J Am Geriatr Soc. 2020. PMID: 32212386
The pandemic of coronavirus disease of 2019 (COVID-19) has global impact unseen since the 1918 worldwide influenza epidemic. ...The group most susceptible to COVID-19 are older adults and those with chronic underlying chronic medical disorders. The population residing in long-term care facilities generally are those who are both old and suffering from multiple comorbidities. ...
The pandemic of coronavirus disease of 2019 (COVID-19) has global impact unseen since the 1918 worldwide influenza epid …
Epidemiological and Clinical Predictors of COVID-19.
Sun Y, Koh V, Marimuthu K, Ng OT, Young B, Vasoo S, Chan M, Lee VJM, De PP, Barkham T, Lin RTP, Cook AR, Leo YS. Sun Y, et al. Clin Infect Dis. 2020 Mar 25:ciaa322. doi: 10.1093/cid/ciaa322. Online ahead of print. Clin Infect Dis. 2020. PMID: 32211755
METHODS: This retrospective case-control study involves subjects (7 to 98 years) presenting at the designated national outbreak screening centre and tertiary care hospital in Singapore for SARS-CoV-2 testing from January 26 to February 16, 2020. ...RESULTS: The study population included 788 subjects, of whom 54 (6.9%) were SARS-CoV-2 positive and 734 (93.1%) were SARS-CoV-2 negative. ...
METHODS: This retrospective case-control study involves subjects (7 to 98 years) presenting at the designated national outbreak screening ce …
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China.
Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, Zeng X, Zhang S. Zhang W, et al. Clin Immunol. 2020 Mar 25;214:108393. doi: 10.1016/j.clim.2020.108393. Online ahead of print. Clin Immunol. 2020. PMID: 32222466 Free PMC article. Review.
The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Reports from China showed that about 20% of patients developed severe disease, resulting in a fatality of 4%. In the past two months, we clinical immunologists participated in multi-rounds of MDT (multidiscipline team) discussion on the anti-inflammation management of critical COVID-19 patients, with our colleagues dispatched from Chinese leading PUMC Hospital to Wuhan to admit and treat the most severe patients. ...
The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Rep …
CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19).
Li K, Fang Y, Li W, Pan C, Qin P, Zhong Y, Liu X, Huang M, Liao Y, Li S. Li K, et al. Eur Radiol. 2020 Mar 25. doi: 10.1007/s00330-020-06817-6. Online ahead of print. Eur Radiol. 2020. PMID: 32215691
OBJECTIVES: To explore the relationship between the imaging manifestations and clinical classification of COVID-19. METHODS: We conducted a retrospective single-center study on patients with COVID-19 from Jan. 18, 2020 to Feb. 7, 2020 in Zhuhai, China. ...CONCLUSIONS: The proportion of clinical mild-type patients with COVID-19 was relatively high; CT was not suitable for independent screening tool. ...
OBJECTIVES: To explore the relationship between the imaging manifestations and clinical classification of COVID-19. METHODS: W …
Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan.
Lian J, Jin X, Hao S, Cai H, Zhang S, Zheng L, Jia H, Hu J, Gao J, Zhang Y, Zhang X, Yu G, Wang X, Gu J, Ye C, Jin C, Lu Y, Yu X, Yu X, Ren Y, Qiu Y, Li L, Sheng J, Yang Y. Lian J, et al. Clin Infect Dis. 2020 Mar 25:ciaa242. doi: 10.1093/cid/ciaa242. Online ahead of print. Clin Infect Dis. 2020. PMID: 32211844
BACKGROUND: The outbreak of COVID-19 has become a big threat to China, with high contagious capacity and varied mortality. This study aimed to investigate the epidemiological and clinical characteristics of older patients with COVID-19 out of Wuhan. ...RESULTS: Total 788 patients with confirmed COVID-19 were selected, where 136 were older patients with corresponding age of 68.28y±7.314y. ...
BACKGROUND: The outbreak of COVID-19 has become a big threat to China, with high contagious capacity and varied mortality. Thi …
Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.
Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Qiu H, et al. Lancet Infect Dis. 2020 Mar 25:S1473-3099(20)30198-5. doi: 10.1016/S1473-3099(20)30198-5. Online ahead of print. Lancet Infect Dis. 2020. PMID: 32220650
BACKGROUND: Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. ...FINDINGS: From Jan 17 to March 1, 2020, 36 children (mean age 8·3 [SD 3·5] years) were identified to be infected with severe acute respiratory syndrome coronavirus 2. ...
BACKGROUND: Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. …
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study.
Elfiky AA. Elfiky AA. Life Sci. 2020 Mar 25:117592. doi: 10.1016/j.lfs.2020.117592. Online ahead of print. Life Sci. 2020. PMID: 32222463 Free PMC article.
AIMS: A new human coronavirus (HCoV), which has been designated SARS-CoV-2, began spreading in December 2019 in Wuhan City, China causing pneumonia called COVID-19. The spread of SARS-CoV-2 has been faster than any other coronaviruses that have succeeded in crossing the animal-human barrier. ...
AIMS: A new human coronavirus (HCoV), which has been designated SARS-CoV-2, began spreading in December 2019 in …
Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers.
Danser AHJ, Epstein M, Batlle D. Danser AHJ, et al. Hypertension. 2020 Mar 25:HYPERTENSIONAHA12015082. doi: 10.1161/HYPERTENSIONAHA.120.15082. Online ahead of print. Hypertension. 2020. PMID: 32208987
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19. ...Because the ACE2 (angiotensin-converting enzyme 2) protein is the receptor that facilitates coronavirus entry into cells, the notion has been popularized that treatment with renin-angiotensin system blockers might increase the risk of developing a severe and fatal severe acute respiratory syndrome coronavirus-2 infection. ...
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data sti …
Why is COVID-19 so mild in children?
Brodin P. Brodin P. Acta Paediatr. 2020 Mar 25. doi: 10.1111/apa.15271. Online ahead of print. Acta Paediatr. 2020. PMID: 32212348
There is an urgent need to understand why the course of the coronavirus that started in late 2019 (COVID-19) is affecting different groups of individuals with varying severity during the ongoing global pandemic. Greater knowledge of the disease, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), will help us to prioritise our limited health resources. ...
There is an urgent need to understand why the course of the coronavirus that started in late 2019 (COVID-19) is affecti …
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