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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1969 1
1974 1
1976 1
1977 1
1979 2
1980 4
1983 2
1984 1
1985 3
1986 4
1987 2
1988 3
1989 2
1990 5
1991 7
1992 6
1993 3
1994 2
1995 6
1996 9
1997 9
1998 12
1999 12
2000 14
2001 15
2002 31
2003 42
2004 65
2005 82
2006 150
2007 175
2008 259
2009 373
2010 424
2011 606
2012 835
2013 1170
2014 1693
2015 2148
2016 2703
2017 3339
2018 4215
2019 5246
2020 3010
2021 8
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23,544 results
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Page 1
The Microbiome.
Silbergeld EK. Silbergeld EK. Toxicol Pathol. 2017 Jan;45(1):190-194. doi: 10.1177/0192623316672073. Epub 2016 Oct 23. Toxicol Pathol. 2017. PMID: 27770110 Review.
The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicology and pharmacology involves challenges to current concepts related to absorption, metabolism, gene:environment, and pathways of response. …
The microbiome is increasingly recognized as a critical component in human development, health, and disease. Its relevance to toxicol …
Mechanisms and consequences of intestinal dysbiosis.
Weiss GA, Hennet T. Weiss GA, et al. Cell Mol Life Sci. 2017 Aug;74(16):2959-2977. doi: 10.1007/s00018-017-2509-x. Epub 2017 Mar 28. Cell Mol Life Sci. 2017. PMID: 28352996 Free article. Review.
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota itself. Natural variations in the gut microbiota can deteriorate to …
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the …
Mapping human microbiome drug metabolism by gut bacteria and their genes.
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL. Zimmermann M, et al. Nature. 2019 Jun;570(7762):462-467. doi: 10.1038/s41586-019-1291-3. Epub 2019 Jun 3. Nature. 2019. PMID: 31158845 Free PMC article.
These microbiome-encoded enzymes can directly and substantially affect intestinal and systemic drug metabolism in mice, and can explain the drug-metabolizing activities of human gut bacteria and communities on the basis of their genomic contents. These …
These microbiome-encoded enzymes can directly and substantially affect intestinal and systemic drug metabolism in mice, and ca …
The gut microbiome and epilepsy.
Dahlin M, Prast-Nielsen S. Dahlin M, et al. EBioMedicine. 2019 Jun;44:741-746. doi: 10.1016/j.ebiom.2019.05.024. Epub 2019 May 31. EBioMedicine. 2019. PMID: 31160269 Free PMC article. Review.
The ketogenic diet is an alternative treatment of drug-resistant epilepsy, although its precise mechanism of action has been unclear. ...Below, we will discuss the scientific evidence of the role of the microbiome in seizure disorders, the impact of the ketogenic di …
The ketogenic diet is an alternative treatment of drug-resistant epilepsy, although its precise mechanism of action has been unclear. …
The role of the microbiome for human health: from basic science to clinical applications.
Mohajeri MH, Brummer RJM, Rastall RA, Weersma RK, Harmsen HJM, Faas M, Eggersdorfer M. Mohajeri MH, et al. Eur J Nutr. 2018 May;57(Suppl 1):1-14. doi: 10.1007/s00394-018-1703-4. Eur J Nutr. 2018. PMID: 29748817 Free PMC article.
The gut microbiota changes dramatically during pregnancy and intrinsic factors (such as stress), in addition to extrinsic factors (such as diet, and drugs) influence the composition and activity of the gut microbiome throughout life. ...This calls for further …
The gut microbiota changes dramatically during pregnancy and intrinsic factors (such as stress), in addition to extrinsic factors (su …
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism.
Huang F, Zheng X, Ma X, Jiang R, Zhou W, Zhou S, Zhang Y, Lei S, Wang S, Kuang J, Han X, Wei M, You Y, Li M, Li Y, Liang D, Liu J, Chen T, Yan C, Wei R, Rajani C, Shen C, Xie G, Bian Z, Li H, Zhao A, Jia W. Huang F, et al. Nat Commun. 2019 Oct 31;10(1):4971. doi: 10.1038/s41467-019-12896-x. Nat Commun. 2019. PMID: 31672964 Free PMC article.
Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. ...Our results shed light into the mechanisms behind the cholesterol- and lipid-lowering effects of Pu …
Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated wit …
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Costea PI, Kultima JR, Li J, Jørgensen T, Levenez F, Dore J; MetaHIT consortium, Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O. Forslund K, et al. Nature. 2015 Dec 10;528(7581):262-266. doi: 10.1038/nature15766. Epub 2015 Dec 2. Nature. 2015. PMID: 26633628 Free PMC article.
In most of these reports, treatment regimens were not controlled for and conclusions could thus be confounded by the effects of various drugs on the microbiota, which may obscure microbial causes, protective factors or diagnostically relevant signals. ...These in tu …
In most of these reports, treatment regimens were not controlled for and conclusions could thus be confounded by the effects of various d
Microbiota and diabetes: an evolving relationship.
Tilg H, Moschen AR. Tilg H, et al. Gut. 2014 Sep;63(9):1513-21. doi: 10.1136/gutjnl-2014-306928. Epub 2014 May 15. Gut. 2014. PMID: 24833634 Review.
Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. ...Interestingly, certain antidiabetic drugs such as metformin also interfere with the intestinal microbiota. Specific me …
Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular dise …
Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions.
Clarke G, Sandhu KV, Griffin BT, Dinan TG, Cryan JF, Hyland NP. Clarke G, et al. Pharmacol Rev. 2019 Apr;71(2):198-224. doi: 10.1124/pr.118.015768. Pharmacol Rev. 2019. PMID: 30890566 Review.
The microbiome plays a key role in health and disease, and there has been considerable interest in therapeutic targeting of the microbiome as well as mining this rich resource in drug discovery efforts. ...Traditionally, clinical studies evaluating the pharma …
The microbiome plays a key role in health and disease, and there has been considerable interest in therapeutic targeting of the mi
Microbiota and Breast Cancer.
Mani S. Mani S. Prog Mol Biol Transl Sci. 2017;151:217-229. doi: 10.1016/bs.pmbts.2017.07.004. Epub 2017 Aug 31. Prog Mol Biol Transl Sci. 2017. PMID: 29096895 Review.
Breast carcinogenesis and/or cancer growth and/or drug sensitivity has a multifactorial etiology-perhaps the least well-characterized aspect being that of the distant environmental influences, namely, the microbiota that inhabit humans. For the purposes of this chap …
Breast carcinogenesis and/or cancer growth and/or drug sensitivity has a multifactorial etiology-perhaps the least well-characterized …
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