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Year Number of Results
1998 2
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2007 1
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2013 4
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72 results

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Page 1
Genetics of glaucoma.
Wiggs JL, Pasquale LR. Wiggs JL, et al. Hum Mol Genet. 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. Hum Mol Genet. 2017. PMID: 28505344 Free PMC article. Review.
Recent studies have suggested possible therapeutic targets for some patients with early-onset glaucoma based on the molecular and cellular events caused by MYOC, OPTN and TBK1 mutations. Diagnostic genetic tests using early-onset glaucoma …
Recent studies have suggested possible therapeutic targets for some patients with early-onset glaucoma based on the mol …
Glaucoma Genes and Mechanisms.
Wiggs JL. Wiggs JL. Prog Mol Biol Transl Sci. 2015;134:315-42. doi: 10.1016/bs.pmbts.2015.04.008. Epub 2015 Jul 15. Prog Mol Biol Transl Sci. 2015. PMID: 26310163 Free PMC article. Review.
While the function of these proteins in health and disease are not completely understood, recent studies are providing insight into underlying disease mechanisms, a critical step toward the development of gene-based therapies. In this review, genes known to cause early- …
While the function of these proteins in health and disease are not completely understood, recent studies are providing insight into underlyi …
Early-onset glaucoma in Axenfeld-Rieger anomaly: long-term surgical results and visual outcome.
Mandal AK, Pehere N. Mandal AK, et al. Eye (Lond). 2016 Jul;30(7):936-42. doi: 10.1038/eye.2016.66. Epub 2016 Apr 8. Eye (Lond). 2016. PMID: 27055677 Free PMC article.
PurposeTo determine the long-term surgical and visual outcomes in Indian children with early-onset glaucoma associated with Axenfeld-Rieger anomaly (ARA).MethodsThis is a retrospective analysis of 44 eyes of 24 consecutive children with early-onset …
PurposeTo determine the long-term surgical and visual outcomes in Indian children with early-onset glaucoma associated …
Childhood and Early Onset Glaucoma Classification and Genetic Profile in a Large Australasian Disease Registry.
Knight LSW, Ruddle JB, Taranath DA, Goldberg I, Smith JEH, Gole G, Chiang MY, Willett F, D'Mellow G, Breen J, Qassim A, Mullany S, Elder JE, Vincent AL, Staffieri SE, Kearns LS, Mackey DA, Luu S, Siggs OM, Souzeau E, Craig JE. Knight LSW, et al. Ophthalmology. 2021 Nov;128(11):1549-1560. doi: 10.1016/j.ophtha.2021.04.016. Epub 2021 Apr 20. Ophthalmology. 2021. PMID: 33892047 Free article.
PURPOSE: To report the relative frequencies of childhood and early onset glaucoma subtypes and their genetic findings in a large single cohort. DESIGN: Retrospective clinical and molecular study. PARTICIPANTS: All individuals with childhood glaucoma (diagnose …
PURPOSE: To report the relative frequencies of childhood and early onset glaucoma subtypes and their genetic findings i …
Rodent genetically modified models of glaucoma.
Loo Y, Chan ASY, Khor CC, Aung T, Wang Z. Loo Y, et al. Mol Aspects Med. 2024 Feb;95:101229. doi: 10.1016/j.mam.2023.101229. Epub 2023 Nov 30. Mol Aspects Med. 2024. PMID: 38039744 Review.
In this review, we will outline genetic models used for studying the major forms of glaucoma, including primary open angle glaucoma, normal tension glaucoma, primary angle closure glaucoma, pigmentary glaucoma, pseudoexfoliation glaucoma, and early onset glaucoma …
In this review, we will outline genetic models used for studying the major forms of glaucoma, including primary open angle glaucoma, normal …
Comparison of delayed-onset glaucoma and early-onset glaucoma after infantile cataract surgery.
Kang KD, Yim HB, Biglan AW. Kang KD, et al. Korean J Ophthalmol. 2006 Mar;20(1):41-6. doi: 10.3341/kjo.2006.20.1.41. Korean J Ophthalmol. 2006. PMID: 16768189 Free PMC article.
RESULTS: There was a bimodal onset of glaucoma after cataract surgery. Early-onset glaucoma occurred at a mean age of 6 months in 15 eyes and delayed-onset glaucoma at a mean age of 12 years in 22 eyes. Early-onset glaucoma was significan …
RESULTS: There was a bimodal onset of glaucoma after cataract surgery. Early-onset glaucoma occurred at a mean age of 6 …
Glaucoma Genetics: Lessons Learned and the New Frontier.
Wiggs JL, Pasquale LR. Wiggs JL, et al. Ophthalmol Glaucoma. 2025 Sep-Oct;8(5S):S27-S32. doi: 10.1016/j.ogla.2025.07.009. Epub 2025 Sep 3. Ophthalmol Glaucoma. 2025. PMID: 40905900 Review.
Genetic analyses have led to the identification of 12 genes primarily responsible for early-onset glaucoma and hundreds of genomic loci influencing adult-onset disease risk. ...Genes responsible for glaucoma and genetic factors influencing disease risk can be …
Genetic analyses have led to the identification of 12 genes primarily responsible for early-onset glaucoma and hundreds …
Outcomes of Primary Combined Trabeculotomy and Trabeculectomy in Early-Onset Glaucoma in Children with Congenital Aniridia.
Senthil S, Uche NJ, Mohamed A, Krishnamurthy R, Badakere S, Mandal AK, Garudadari C. Senthil S, et al. Ophthalmol Glaucoma. 2021 May-Jun;4(3):305-311. doi: 10.1016/j.ogla.2020.09.012. Epub 2020 Sep 20. Ophthalmol Glaucoma. 2021. PMID: 32966898
PARTICIPANTS: Sixty-six eyes of 35 children with congenital aniridia and early-onset glaucoma who underwent CTT between May 1997 and June 2015 were included. METHODS: Success was defined as complete when intraocular pressure (IOP) was more than 5 mmHg and les …
PARTICIPANTS: Sixty-six eyes of 35 children with congenital aniridia and early-onset glaucoma who underwent CTT between …
The inheritance of juvenile onset primary open angle glaucoma.
Gupta V, Somarajan BI, Gupta S, Chaurasia AK, Kumar S, Dutta P, Gupta V, Sharma A, Tayo BO, Nischal K. Gupta V, et al. Clin Genet. 2017 Aug;92(2):134-142. doi: 10.1111/cge.12906. Epub 2017 Feb 16. Clin Genet. 2017. PMID: 27779752 Review.
72 results