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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 3
1975 1
1976 1
1978 1
1979 1
1980 5
1981 5
1982 3
1983 5
1984 4
1985 4
1986 4
1987 4
1988 4
1989 5
1990 2
1991 5
1992 5
1993 3
1994 1
1995 2
1996 2
1997 2
1998 7
1999 3
2000 4
2001 2
2002 2
2003 6
2004 3
2005 4
2006 5
2007 4
2008 3
2009 13
2010 6
2011 14
2012 11
2013 10
2014 9
2015 7
2016 8
2017 9
2018 13
2019 9
2020 7
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Search Results

211 results
Results by year
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Page 1
Sickle cell trait diagnosis: clinical and social implications.
Naik RP, Haywood C Jr. Naik RP, et al. Hematology Am Soc Hematol Educ Program. 2015;2015(1):160-7. doi: 10.1182/asheducation-2015.1.160. Hematology Am Soc Hematol Educ Program. 2015. PMID: 26637716 Free PMC article. Review.
In 1949, homozygous Hb S or sickle cell disease (SCD) became the first inherited condition identified at the molecular level; however, since then, both SCD and heterozygous Hb S, sickle cell trait (SCT), have endured a long and complicated history. Has …
In 1949, homozygous Hb S or sickle cell disease (SCD) became the first inherited condition identified at the molecular level; …
Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies.
Shang X, Peng Z, Ye Y, Asan, Zhang X, Chen Y, Zhu B, Cai W, Chen S, Cai R, Guo X, Zhang C, Zhou Y, Huang S, Liu Y, Chen B, Yan S, Chen Y, Ding H, Yin X, Wu L, He J, Huang D, He S, Yan T, Fan X, Zhou Y, Wei X, Zhao S, Cai D, Guo F, Zhang Q, Li Y, Zhang X, Lu H, Huang H, Guo J, Zhu F, Yuan Y, Zhang L, Liu N, Li Z, Jiang H, Zhang Q, Zhang Y, Juhari WKW, Hanafi S, Zhou W, Xiong F, Yang H, Wang J, Zilfalil BA, Qi M, Yang Y, Yin Y, Mao M, Xu X. Shang X, et al. EBioMedicine. 2017 Sep;23:150-159. doi: 10.1016/j.ebiom.2017.08.015. Epub 2017 Aug 17. EBioMedicine. 2017. PMID: 28865746 Free PMC article. Clinical Trial.
We validated the assay by using 2522 subjects affected with hemoglobinopathies and applied it to carrier testing in a cohort of 10,111 couples who were also screened through traditional methods. ...We describe a comprehensive NGS-based test that offers advant …
We validated the assay by using 2522 subjects affected with hemoglobinopathies and applied it to carrier testing in a cohort o …
Increasing prevalence of thalassemia in America: Implications for primary care.
Sayani FA, Kwiatkowski JL. Sayani FA, et al. Ann Med. 2015;47(7):592-604. doi: 10.3109/07853890.2015.1091942. Epub 2015 Nov 5. Ann Med. 2015. PMID: 26541064 Review.
Thalassemia, once a rarity in the United States, is increasingly encountered in clinical practice due to shifts in immigration. Early carrier screening in at-risk populations can help clinicians implement genetic counseling and prevent new cases …
Thalassemia, once a rarity in the United States, is increasingly encountered in clinical practice due to shifts in immigration …
Sickle Cell Anemia and Its Phenotypes.
Williams TN, Thein SL. Williams TN, et al. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:113-147. doi: 10.1146/annurev-genom-083117-021320. Epub 2018 Apr 11. Annu Rev Genomics Hum Genet. 2018. PMID: 29641911 Review.
In the 100 years since sickle cell anemia (SCA) was first described in the medical literature, studies of its molecular and pathophysiological basis have been at the vanguard of scientific discovery. ...Meanwhile, an unprecedented number of new drugs aimed at both t …
In the 100 years since sickle cell anemia (SCA) was first described in the medical literature, studies of its molecular and pa …
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.
Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA. Grevet JD, et al. Science. 2018 Jul 20;361(6399):285-290. doi: 10.1126/science.aao0932. Science. 2018. PMID: 30026227 Free PMC article.
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. ...Taken together, these results suggest HRI as a potential therapeutic target for hemoglobinopathies
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disea …
Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA.
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM. Zhang J, et al. Nat Med. 2019 Mar;25(3):439-447. doi: 10.1038/s41591-018-0334-x. Epub 2019 Jan 28. Nat Med. 2019. PMID: 30692697
Current non-invasive prenatal screening is targeted toward the detection of chromosomal abnormalities in the fetus(1,2). However, screening for many dominant monogenic disorders associated with de novo mutations is not available, despite their relatively high …
Current non-invasive prenatal screening is targeted toward the detection of chromosomal abnormalities in the fetus(1,2). Howev …
Unprepared and Misinformed Parents of Children with Sickle Cell Disease: Time to Rethink Awareness Campaigns.
Aderotoye-Oni S, Diaku-Akinwumi IN, Adeniran A, Falase B. Aderotoye-Oni S, et al. Cureus. 2018 Dec 31;10(12):e3806. doi: 10.7759/cureus.3806. Cureus. 2018. PMID: 30868020 Free PMC article.
Of 133 respondents, 53% of the parents were unaware of being sickle cell carriers and did not expect to have children with SCD. ...Standardization and improved quality control of laboratory testing involving screening of the sickle cell t …
Of 133 respondents, 53% of the parents were unaware of being sickle cell carriers and did not expect to have children w …
Sickle Cell Trait and Renal Function in Hispanics in the United States: The Northern Manhattan Study.
Dueker ND, Della-Morte D, Rundek T, Sacco RL, Blanton SH. Dueker ND, et al. Ethn Dis. 2017 Jan 19;27(1):11-14. doi: 10.18865/ed.27.1.11. Ethn Dis. 2017. PMID: 28115816 Free PMC article.
Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United States; the disorder results in the production of abnormal hemoglobin. ...While the presence of a single mutation (sickle cell
Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United State
The current state of sickle cell trait: implications for reproductive and genetic counseling.
Pecker LH, Naik RP. Pecker LH, et al. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):474-481. doi: 10.1182/asheducation-2018.1.474. Hematology Am Soc Hematol Educ Program. 2018. PMID: 30504348 Free PMC article. Review.
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening.
Point-of-care screening for sickle cell disease in low-resource settings: A multi-center evaluation of HemoTypeSC, a novel rapid test.
Steele C, Sinski A, Asibey J, Hardy-Dessources MD, Elana G, Brennan C, Odame I, Hoppe C, Geisberg M, Serrao E, Quinn CT. Steele C, et al. Am J Hematol. 2019 Jan;94(1):39-45. doi: 10.1002/ajh.25305. Epub 2018 Oct 31. Am J Hematol. 2019. PMID: 30290004 Free PMC article. Clinical Trial.
Sickle cell disease (SCD) is a common, life-threatening genetic disorder that is best managed when diagnosed early by newborn screening. ...The test had 100% sensitivity and specificity for sickle cell anemia. Sensitivity and specificity
Sickle cell disease (SCD) is a common, life-threatening genetic disorder that is best managed when diagnosed early by n
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