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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 2
1973 1
1974 2
1980 1
1981 3
1987 2
1988 2
1990 2
1992 2
1994 2
1995 2
1996 4
1997 5
1998 9
1999 4
2000 4
2001 6
2002 5
2003 3
2004 7
2005 12
2006 11
2007 17
2008 16
2009 14
2010 15
2011 16
2012 9
2013 12
2014 14
2015 14
2016 19
2017 12
2018 24
2019 17
2020 18
2021 3
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271 results
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Page 1
Sickle-cell disease.
Rees DC, Williams TN, Gladwin MT. Rees DC, et al. Lancet. 2010 Dec 11;376(9757):2018-31. doi: 10.1016/S0140-6736(10)61029-X. Epub 2010 Dec 3. Lancet. 2010. PMID: 21131035 Review.
Sickle cell disease.
Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP. Kato GJ, et al. Nat Rev Dis Primers. 2018 Mar 15;4:18010. doi: 10.1038/nrdp.2018.10. Nat Rev Dis Primers. 2018. PMID: 29542687 Free article. Review.
Early diagnosis is crucial to improve survival, and universal newborn screening programmes have been implemented in some countries but are challenging in low-income, high-burden settings....
Early diagnosis is crucial to improve survival, and universal newborn screening programmes have been implemented in some countries bu …
Sickle cell disease.
Ware RE, de Montalembert M, Tshilolo L, Abboud MR. Ware RE, et al. Lancet. 2017 Jul 15;390(10091):311-323. doi: 10.1016/S0140-6736(17)30193-9. Epub 2017 Feb 1. Lancet. 2017. PMID: 28159390 Review.
Several new therapeutic options are in development, including gene therapy and gene editing. Recent advances include systematic universal screening for stroke risk, improved management of iron overload using oral chelators and non-invasive MRI measurements, and point-of-ca …
Several new therapeutic options are in development, including gene therapy and gene editing. Recent advances include systematic universal …
Sickle cell disease.
Strouse J. Strouse J. Handb Clin Neurol. 2016;138:311-24. doi: 10.1016/B978-0-12-802973-2.00018-5. Handb Clin Neurol. 2016. PMID: 27637966 Review.
It is the most common serious genetic diseases in childhood, affecting approximately 1 in 2500 births and 100 000 individuals in the USA, in addition to 300 000 new cases globally each year. Central nervous system injury is the most debilitating frequent complication of SC …
It is the most common serious genetic diseases in childhood, affecting approximately 1 in 2500 births and 100 000 individuals in the USA
Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.
Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ. Naik RP, et al. Ann Intern Med. 2018 Nov 6;169(9):619-627. doi: 10.7326/M18-1161. Epub 2018 Oct 30. Ann Intern Med. 2018. PMID: 30383109 Free PMC article.
DATA EXTRACTION: A single reviewer extracted study data, which was checked by another; 2 reviewers independently assessed study quality; and strength of evidence was assessed by consensus. DATA SYNTHESIS: Of 7083 screened studies, 41 met inclusion criteria. High-strength e …
DATA EXTRACTION: A single reviewer extracted study data, which was checked by another; 2 reviewers independently assessed study quality; and …
Non-transfusion-dependent thalassemia and thalassemia intermedia: epidemiology, complications, and management.
Vichinsky E. Vichinsky E. Curr Med Res Opin. 2016;32(1):191-204. doi: 10.1185/03007995.2015.1110128. Epub 2015 Nov 25. Curr Med Res Opin. 2016. PMID: 26479125 Review.
CONCLUSIONS: Management of NTDT requires a comprehensive approach, beginning with screening and prenatal diagnosis, monitoring for iron overload and associated complications, and iron chelation therapy. ...
CONCLUSIONS: Management of NTDT requires a comprehensive approach, beginning with screening and prenatal diagnosis, monitoring for ir …
The current state of sickle cell trait: implications for reproductive and genetic counseling.
Pecker LH, Naik RP. Pecker LH, et al. Blood. 2018 Nov 29;132(22):2331-2338. doi: 10.1182/blood-2018-06-848705. Blood. 2018. PMID: 30487130 Free PMC article. Review.
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one …
Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozy …
Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment.
Hariri E, Mansour A, El Alam A, Daaboul Y, Korjian S, Aoun Bahous S. Hariri E, et al. Int Urol Nephrol. 2018 Jun;50(6):1075-1083. doi: 10.1007/s11255-018-1803-3. Epub 2018 Jan 30. Int Urol Nephrol. 2018. PMID: 29383580 Review.
Markers of renal injury, such as proteinuria and tubular dysfunction, have been associated with outcomes among patients with sickle cell nephropathy and provide means for early detection of nephropathy and screening prior to progression to renal failure. In small-sized cli …
Markers of renal injury, such as proteinuria and tubular dysfunction, have been associated with outcomes among patients with sickle cell nep …
Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa.
Tshilolo L, Tomlinson G, Williams TN, Santos B, Olupot-Olupot P, Lane A, Aygun B, Stuber SE, Latham TS, McGann PT, Ware RE; REACH Investigators. Tshilolo L, et al. N Engl J Med. 2019 Jan 10;380(2):121-131. doi: 10.1056/NEJMoa1813598. Epub 2018 Dec 1. N Engl J Med. 2019. PMID: 30501550 Free PMC article. Clinical Trial.
RESULTS: A total of 635 children were fully enrolled; 606 children completed screening and began receiving hydroxyurea at a mean (SD) dose of 17.51.8 mg per kilogram per day. ...
RESULTS: A total of 635 children were fully enrolled; 606 children completed screening and began receiving hydroxyurea at a mean (SD) …
Increasing prevalence of thalassemia in America: Implications for primary care.
Sayani FA, Kwiatkowski JL. Sayani FA, et al. Ann Med. 2015;47(7):592-604. doi: 10.3109/07853890.2015.1091942. Epub 2015 Nov 5. Ann Med. 2015. PMID: 26541064 Review.
Thalassemia, once a rarity in the United States, is increasingly encountered in clinical practice due to shifts in immigration. Early carrier screening in at-risk populations can help clinicians implement genetic counseling and prevent new cases. ...
Thalassemia, once a rarity in the United States, is increasingly encountered in clinical practice due to shifts in immigration …
271 results
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