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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1952 1
1958 1
1959 1
1963 1
1964 1
1965 3
1967 1
1973 1
1975 3
1977 1
1978 1
1979 8
1980 3
1981 2
1982 3
1983 5
1984 5
1985 2
1986 3
1987 7
1988 3
1989 2
1990 3
1991 7
1992 8
1993 11
1994 7
1995 6
1996 11
1997 17
1998 19
1999 15
2000 29
2001 32
2002 34
2003 27
2004 40
2005 43
2006 63
2007 49
2008 58
2009 60
2010 95
2011 71
2012 78
2013 90
2014 98
2015 92
2016 100
2017 83
2018 83
2019 95
2020 94
2021 38
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1,444 results
Results by year
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Page 1
Epigenetic Mechanisms of Longevity and Aging.
Sen P, Shah PP, Nativio R, Berger SL. Sen P, et al. Cell. 2016 Aug 11;166(4):822-839. doi: 10.1016/j.cell.2016.07.050. Cell. 2016. PMID: 27518561 Free PMC article. Review.
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these p …
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. A …
Biology of Healthy Aging and Longevity.
Carmona JJ, Michan S. Carmona JJ, et al. Rev Invest Clin. 2016 Jan-Feb;68(1):7-16. Rev Invest Clin. 2016. PMID: 27028172 Free article. Review.
Collectively, these data offer powerful insights into healthy aging and longevity. For example, molecular integrity of the genome, telomere length, epigenetic landscape stability, and protein homeostasis are all features linked to "youthful" states. ...
Collectively, these data offer powerful insights into healthy aging and longevity. For example, molecular integrity of the genome, te …
Promoting health and longevity through diet: from model organisms to humans.
Fontana L, Partridge L. Fontana L, et al. Cell. 2015 Mar 26;161(1):106-118. doi: 10.1016/j.cell.2015.02.020. Cell. 2015. PMID: 25815989 Free PMC article. Review.
The metabolic, molecular, and cellular mechanisms that mediate both improvement in health during aging to diet and genetic variation in the response to diet are being identified. These new findings are opening the way to specific dietary and pharmacological interventions t …
The metabolic, molecular, and cellular mechanisms that mediate both improvement in health during aging to diet and genetic variation …
Growth Hormone Deficiency: Health and Longevity.
Aguiar-Oliveira MH, Bartke A. Aguiar-Oliveira MH, et al. Endocr Rev. 2019 Apr 1;40(2):575-601. doi: 10.1210/er.2018-00216. Endocr Rev. 2019. PMID: 30576428 Free PMC article. Review.
The important role of GH in the control of mammalian longevity was first deduced from extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with isolated GHD (IGHD) due to GHRH or GHRH receptor mutations, combined deficiency of GH, prolactin, a …
The important role of GH in the control of mammalian longevity was first deduced from extended longevity of mice with genetic GH defi …
Genetics of healthy aging and longevity.
Brooks-Wilson AR. Brooks-Wilson AR. Hum Genet. 2013 Dec;132(12):1323-38. doi: 10.1007/s00439-013-1342-z. Epub 2013 Aug 8. Hum Genet. 2013. PMID: 23925498 Free PMC article. Review.
The impact of these SNPs, which may exert joint effects, may be obscured by gene-environment interactions or inter-ethnic differences. GWAS and whole genome sequencing data both show that the risk alleles defined by GWAS of common complex diseases are, perhaps surprisingly …
The impact of these SNPs, which may exert joint effects, may be obscured by gene-environment interactions or inter-ethnic differences. GWAS …
Nutrition and longevity - From mechanisms to uncertainties.
Ekmekcioglu C. Ekmekcioglu C. Crit Rev Food Sci Nutr. 2020;60(18):3063-3082. doi: 10.1080/10408398.2019.1676698. Epub 2019 Oct 21. Crit Rev Food Sci Nutr. 2020. PMID: 31631676 Review.
Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans. ...
Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans. ...
Genetic and epigenetic regulation of human aging and longevity.
Morris BJ, Willcox BJ, Donlon TA. Morris BJ, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1718-1744. doi: 10.1016/j.bbadis.2018.08.039. Epub 2018 Sep 1. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31109447 Free PMC article. Review.
Here we summarize the latest data on genetic and epigenetic contributions to human aging and longevity. Whereas environmental and lifestyle factors are important at younger ages, the contribution of genetics appears more important in reaching extreme old age. Gen
Here we summarize the latest data on genetic and epigenetic contributions to human aging and longevity. Whereas environmental and lif …
Longevity and aging. Mechanisms and perspectives.
Labat-Robert J, Robert L. Labat-Robert J, et al. Pathol Biol (Paris). 2015 Dec;63(6):272-6. doi: 10.1016/j.patbio.2015.08.001. Epub 2015 Sep 26. Pathol Biol (Paris). 2015. PMID: 26416405 Review.
Every measurable physiological function declines with specific speeds over a wide range. The mechanisms involved are also different, genetic factors are of importance for longevity determinations. The best-known genes involved are the Sirtuins, active at the genetic
Every measurable physiological function declines with specific speeds over a wide range. The mechanisms involved are also different, gene
Autophagy and Longevity.
Nakamura S, Yoshimori T. Nakamura S, et al. Mol Cells. 2018 Jan 31;41(1):65-72. doi: 10.14348/molcells.2018.2333. Epub 2018 Jan 23. Mol Cells. 2018. PMID: 29370695 Free PMC article. Review.
Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis. Recent genetic evidence indicates that autophagy has a crucial role in the regulation of animal lifespan. ...
Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis. Recent genetic evidence indicates th …
Metabolic Control of Longevity.
López-Otín C, Galluzzi L, Freije JMP, Madeo F, Kroemer G. López-Otín C, et al. Cell. 2016 Aug 11;166(4):802-821. doi: 10.1016/j.cell.2016.07.031. Cell. 2016. PMID: 27518560 Free article. Review.
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. ...
Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence met …
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