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247 results
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Page 1
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.
Pone EJ, Lou Z, Lam T, Greenberg ML, Wang R, Xu Z, Casali P. Pone EJ, et al. Autoimmunity. 2015 Feb;48(1):1-12. doi: 10.3109/08916934.2014.993027. Autoimmunity. 2015. PMID: 25536171 Free PMC article.
In the presence of BCR crosslinking, LPS synergized with a TLR1/2 ligand (Pam3CSK4) in CSR induction, but much less efficiently with a TLR7 (R-848) or TLR9 (CpG) ligand. ...The CSR inhibition by TLR9 was associated with the reduction in AID expression and/or …
In the presence of BCR crosslinking, LPS synergized with a TLR1/2 ligand (Pam3CSK4) in CSR induction, but much less eff …
Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes.
Shukla S, Richardson ET, Drage MG, Boom WH, Harding CV. Shukla S, et al. Infect Immun. 2018 Sep 21;86(10):e00450-18. doi: 10.1128/IAI.00450-18. Print 2018 Oct. Infect Immun. 2018. PMID: 30037791 Free PMC article.
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. LprG, LAM, and LM were all found to bind to TLR2 in the absence of TLR1, but not to TLR1 in the absence of TLR2. …
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. L …
A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.
Shimizu T, Kida Y, Kuwano K. Shimizu T, et al. J Immunol. 2005 Oct 1;175(7):4641-6. doi: 10.4049/jimmunol.175.7.4641. J Immunol. 2005. PMID: 16177110 Free article.
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicate that the activation of NF-kappaB by F0F1-ATPase is dependent on TLR1, TLR2, and TLR6. ...Thus, a dipalmitoylated lipoprot
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicat …
TLR2-mediated leukocyte trafficking to the developing brain.
Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C. Mottahedin A, et al. J Leukoc Biol. 2017 Jan;101(1):297-305. doi: 10.1189/jlb.3A1215-568R. Epub 2016 Aug 4. J Leukoc Biol. 2017. PMID: 27493242
Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or TLR4 (LPS) agonist, and the peripheral and central cytokine and chemokine response was determined. ...Although P3C and LPS induced a sim …
Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or TLR …
Molecular and functional characterization of Toll-like receptor (Tlr)1 and Tlr2 in common carp (Cyprinus carpio).
Fink IR, Pietretti D, Voogdt CGP, Westphal AH, Savelkoul HFJ, Forlenza M, Wiegertjes GF. Fink IR, et al. Fish Shellfish Immunol. 2016 Sep;56:70-83. doi: 10.1016/j.fsi.2016.06.049. Epub 2016 Jun 29. Fish Shellfish Immunol. 2016. PMID: 27368535 Free article.
Furthermore, the carp sequences exhibited a good three-dimensional fit with the heterodimer structure of human TLR1-TLR2, including the potential to bind to the ligand Pam3CSK4. This supports the possible formation of carp Tlr1-Tlr2 heterodimers …
Furthermore, the carp sequences exhibited a good three-dimensional fit with the heterodimer structure of human TLR1-TLR2, incl …
Effects of Toll-like receptor ligands on RAW 264.7 macrophage morphology and zymosan phagocytosis.
Sigola LB, Fuentes AL, Millis LM, Vapenik J, Murira A. Sigola LB, et al. Tissue Cell. 2016 Aug;48(4):389-96. doi: 10.1016/j.tice.2016.04.002. Epub 2016 Apr 22. Tissue Cell. 2016. PMID: 27157550
In this study we compared the effects of the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS), flagellin, the synthetic bacterial triacylated lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), Polyinosinic:polycytidylic acid (Poly I:C), and macrophage-activating lip …
In this study we compared the effects of the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS), flagellin, the synthetic bacterial t …
SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent Macrophage Activation and Proinflammation through NF-κB and MAP Kinase Signaling.
Tapader R, Bose D, Dutta P, Das S, Pal A. Tapader R, et al. Infect Immun. 2018 Aug 22;86(9):e00399-18. doi: 10.1128/IAI.00399-18. Print 2018 Sep. Infect Immun. 2018. PMID: 29891541 Free PMC article.
SslE (YghJ), a cell surface-associated and secreted lipoprotein, was identified as a potential vaccine candidate for extraintestinal pathogenic Escherichia coli, providing nearly complete protection from sepsis in a mouse model. ...In this study, we showed that SslE specif …
SslE (YghJ), a cell surface-associated and secreted lipoprotein, was identified as a potential vaccine candidate for extraintestinal …
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NFκB-dependent manner. ...In the MLL-AF9 AML mouse mo …
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis …
Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts.
Della Mina E, Borghesi A, Zhou H, Bougarn S, Boughorbel S, Israel L, Meloni I, Chrabieh M, Ling Y, Itan Y, Renieri A, Mazzucchelli I, Basso S, Pavone P, Falsaperla R, Ciccone R, Cerbo RM, Stronati M, Picard C, Zuffardi O, Abel L, Chaussabel D, Marr N, Li X, Casanova JL, Puel A. Della Mina E, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E514-E523. doi: 10.1073/pnas.1620139114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069966 Free PMC article.
The IRAK-1 protein was completely absent from the patient's fibroblasts, which responded very poorly to all TLR2/6 (PAM(2)CSK(4), LTA, FSL-1), TLR1/2 (PAM(3)CSK(4)), and TLR4 (LPS, MPLA) agonists tested but had almost unimpaired responses …
The IRAK-1 protein was completely absent from the patient's fibroblasts, which responded very poorly to all TLR2/6 (PAM(2
Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.
Grabowski M, Murgueitio MS, Bermudez M, Rademann J, Wolber G, Weindl G. Grabowski M, et al. Biochem Pharmacol. 2018 Aug;154:148-160. doi: 10.1016/j.bcp.2018.04.018. Epub 2018 Apr 22. Biochem Pharmacol. 2018. PMID: 29684378
Toll-like receptor 2 (TLR2) induces early inflammatory responses to pathogen and damage-associated molecular patterns trough heterodimerization with either TLR1 or TLR6. ...Concentration ratio analysis identified both compounds as competitive antagonists of P …
Toll-like receptor 2 (TLR2) induces early inflammatory responses to pathogen and damage-associated molecular patterns trough h …
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