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255 results
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Page 1
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.
Mitsui Y, Hou L, Huang X, Odegard KC, Pereira LM, Yuki K. Mitsui Y, et al. Anesth Analg. 2020 Aug;131(2):631-639. doi: 10.1213/ANE.0000000000004741. Anesth Analg. 2020. PMID: 32149756 Free PMC article.
An anesthetic that affected the activation was subjected to in silico rigid docking simulation on TLR2. To test our prediction that sevoflurane and a TLR1/TLR2 ligand Pam3CSK4 would compete for the same pocket of TLR2, we performed Pam3CSK4
An anesthetic that affected the activation was subjected to in silico rigid docking simulation on TLR2. To test our prediction that s …
TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects.
Kaur A, Kaushik D, Piplani S, Mehta SK, Petrovsky N, Salunke DB. Kaur A, et al. J Med Chem. 2021 Jan 14;64(1):233-278. doi: 10.1021/acs.jmedchem.0c01627. Epub 2020 Dec 21. J Med Chem. 2021. PMID: 33346636 Review.
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and small heterocyclic molecules. We described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chemistry for th …
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and s …
A triacylated lipoprotein from Mycoplasma genitalium activates NF-kappaB through Toll-like receptor 1 (TLR1) and TLR2.
Shimizu T, Kida Y, Kuwano K. Shimizu T, et al. Infect Immun. 2008 Aug;76(8):3672-8. doi: 10.1128/IAI.00257-08. Epub 2008 May 12. Infect Immun. 2008. PMID: 18474641 Free PMC article.
The activation of NF-kappaB by MG149 was inhibited by a dominant negative (DN) construct of TLR1 but not by a DN construct of TLR6. These results indicate that the activation of NF-kappaB by MG149 is dependent on TLR1 and TLR2. A synthetic lipopeptide derived …
The activation of NF-kappaB by MG149 was inhibited by a dominant negative (DN) construct of TLR1 but not by a DN construct of TLR6. T …
Activation of Different Heterodimers of TLR2 Distinctly Mediates Pain and Itch.
Wang TT, Xu XY, Lin W, Hu DD, Shi W, Jia X, Wang H, Song NJ, Zhang YQ, Zhang L. Wang TT, et al. Neuroscience. 2020 Mar 1;429:245-255. doi: 10.1016/j.neuroscience.2020.01.010. Epub 2020 Jan 16. Neuroscience. 2020. PMID: 31954829
The TLR2 agonist Pam3CSK4, which targets TLR2/1 heterodimers, evoked pain and itch behavior, whereas lipoteichoic acid (LTA) and zymosan, which recognize TLR2/6 heterodimers, produced only pain response. ...However, the enhancement of [Ca2(+)](i) was l …
The TLR2 agonist Pam3CSK4, which targets TLR2/1 heterodimers, evoked pain and itch behavior, whereas lipoteichoic acid …
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.
van Bergenhenegouwen J, Plantinga TS, Joosten LA, Netea MG, Folkerts G, Kraneveld AD, Garssen J, Vos AP. van Bergenhenegouwen J, et al. J Leukoc Biol. 2013 Nov;94(5):885-902. doi: 10.1189/jlb.0113003. Epub 2013 Aug 29. J Leukoc Biol. 2013. PMID: 23990624 Review.
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand speci …
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is uniqu …
TLR2-mediated leukocyte trafficking to the developing brain.
Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C. Mottahedin A, et al. J Leukoc Biol. 2017 Jan;101(1):297-305. doi: 10.1189/jlb.3A1215-568R. Epub 2016 Aug 4. J Leukoc Biol. 2017. PMID: 27493242
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking. Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or T …
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking …
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFkappaB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NFkappaB-dependent manner. ...Our results demonstrate …
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis …
Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells.
Bérubé J, Bourdon C, Yao Y, Rousseau S. Bérubé J, et al. Cell Signal. 2009 Mar;21(3):448-56. doi: 10.1016/j.cellsig.2008.12.001. Epub 2008 Dec 10. Cell Signal. 2009. PMID: 19121387
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capacity to up-regulate Interleukin-8 (IL-8) and Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) in airway epithelial cel …
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capac …
TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria.
Raieli S, Trichot C, Korniotis S, Pattarini L, Soumelis V. Raieli S, et al. PLoS Biol. 2019 Apr 24;17(4):e3000209. doi: 10.1371/journal.pbio.3000209. eCollection 2019 Apr. PLoS Biol. 2019. PMID: 31017904 Free PMC article.
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipoproteins. We demonstrated that pDCs differentially respond to gram+ bacteria through the TLR1/2 pathway. ...Mechanistically …
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipop
A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.
Shimizu T, Kida Y, Kuwano K. Shimizu T, et al. J Immunol. 2005 Oct 1;175(7):4641-6. doi: 10.4049/jimmunol.175.7.4641. J Immunol. 2005. PMID: 16177110 Free article.
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicate that the activation of NF-kappaB by F0F1-ATPase is dependent on TLR1, TLR2, and TLR6. ...Thus, a dipalmitoylated lipoprot
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicat …
255 results
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