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Page 1
Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes.
Shukla S, Richardson ET, Drage MG, Boom WH, Harding CV. Shukla S, et al. Infect Immun. 2018 Sep 21;86(10):e00450-18. doi: 10.1128/IAI.00450-18. Print 2018 Oct. Infect Immun. 2018. PMID: 30037791 Free PMC article.
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. LprG, LAM, and LM were all found to bind to TLR2 in the absence of TLR1, but not to TLR1 in the absence of TLR2. …
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. L …
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.
Pone EJ, Lou Z, Lam T, Greenberg ML, Wang R, Xu Z, Casali P. Pone EJ, et al. Autoimmunity. 2015 Feb;48(1):1-12. doi: 10.3109/08916934.2014.993027. Autoimmunity. 2015. PMID: 25536171 Free PMC article.
In the presence of BCR crosslinking, LPS synergized with a TLR1/2 ligand (Pam3CSK4) in CSR induction, but much less efficiently with a TLR7 (R-848) or TLR9 (CpG) ligand. ...Overall, by addressing the interaction of TLR1/2, TLR4, TLR7 and TLR9 in the induction …
In the presence of BCR crosslinking, LPS synergized with a TLR1/2 ligand (Pam3CSK4) in CSR induction, but much less efficientl …
Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation.
Kim J, Durai P, Jeon D, Jung ID, Lee SJ, Park YM, Kim Y. Kim J, et al. Nutrients. 2018 Jul 5;10(7):868. doi: 10.3390/nu10070868. Nutrients. 2018. PMID: 29976865 Free PMC article.
Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether phloretin acts as an inhibitor of TLR2/1 heterodimerization using the TLR2/1 agonist Pam₃CSK₄. ...Overall, we confirmed that phloretin inh …
Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether phloretin ac …
TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria.
Raieli S, Trichot C, Korniotis S, Pattarini L, Soumelis V. Raieli S, et al. PLoS Biol. 2019 Apr 24;17(4):e3000209. doi: 10.1371/journal.pbio.3000209. eCollection 2019 Apr. PLoS Biol. 2019. PMID: 31017904 Free PMC article.
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipoproteins. ...Mechanistically, we demonstrated that these differences relied on diverse signaling pathways activated by TLR1/2. MAPK and N …
We show here that human primary pDCs express toll-like receptor 1 (TLR1) and 2 (TLR2) and respond to bacterial lipoproteins …
Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs.
Krock E, Rosenzweig DH, Currie JB, Bisson DG, Ouellet JA, Haglund L. Krock E, et al. Sci Rep. 2017 Dec 7;7(1):17184. doi: 10.1038/s41598-017-17472-1. Sci Rep. 2017. PMID: 29215065 Free PMC article.
Nucleus pulposus (NP) cells isolated from non-degenerating discs increase IL-1β and nerve growth factor gene expression following treatment with Pam2CSK4 (TLR2/6 agonist) but not Pam3CSK4 (TLR1/2 agonist). Challenging NP cells with Pam2CSK4 or 30 kDa fibronec …
Nucleus pulposus (NP) cells isolated from non-degenerating discs increase IL-1β and nerve growth factor gene expression following treatment …
Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands.
Törőcsik D, Kovács D, Póliska S, Szentkereszty-Kovács Z, Lovászi M, Hegyi K, Szegedi A, Zouboulis CC, Ståhle M. Törőcsik D, et al. PLoS One. 2018 Jun 21;13(6):e0198323. doi: 10.1371/journal.pone.0198323. eCollection 2018. PLoS One. 2018. PMID: 29927962 Free PMC article.
In this work we performed global gene expression profile analysis with functional clustering of the differentially regulated genes of TLR1/2 (PAM3CSK4)- and TLR4 (lipopolysaccharide [LPS])-activated SZ95 sebocytes. Both TLR1/2- and 4-activation promoted infla …
In this work we performed global gene expression profile analysis with functional clustering of the differentially regulated genes of TLR …
TLR1/TLR2 signaling blocks the suppression of monocytic myeloid-derived suppressor cell by promoting its differentiation into M1-type macrophage.
Deng Y, Yang J, Qian J, Liu R, Huang E, Wang Y, Luo F, Chu Y. Deng Y, et al. Mol Immunol. 2019 Aug;112:266-273. doi: 10.1016/j.molimm.2019.06.006. Epub 2019 Jun 15. Mol Immunol. 2019. PMID: 31212097
In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited t …
In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice t …
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NFκB-dependent manner. ...In the MLL-AF9 AML mouse model, tr …
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis …
A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer.
Rammensee HG, Wiesmüller KH, Chandran PA, Zelba H, Rusch E, Gouttefangeas C, Kowalewski DJ, Di Marco M, Haen SP, Walz JS, Gloria YC, Bödder J, Schertel JM, Tunger A, Müller L, Kießler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber ANR, Pichler BJ, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanović S, Löffler MW. Rammensee HG, et al. J Immunother Cancer. 2019 Nov 15;7(1):307. doi: 10.1186/s40425-019-0796-5. J Immunother Cancer. 2019. PMID: 31730025 Free PMC article.
CASE PRESENTATION: We now designed a new water-soluble synthetic Pam(3)Cys-derivative, named XS15 and characterized it in vitro by a TLR2 NF-κB luciferase reporter assay. ...
CASE PRESENTATION: We now designed a new water-soluble synthetic Pam(3)Cys-derivative, named XS15 and characterized it in vitro by a TLR2 …
Expression of toll-like receptors and their regulatory roles in murine cardiac telocytes.
Li S, Shen X, He S. Li S, et al. J Cell Mol Med. 2019 Aug;23(8):5360-5368. doi: 10.1111/jcmm.14416. Epub 2019 Jun 24. J Cell Mol Med. 2019. PMID: 31232516 Free PMC article.
Our results showed that purified telocytes expressed TLR2, TLR3 and TLR5. In particular, telocytes expressed high levels of TLR2 as observed using flow cytometry. When we stimulated telocytes with TLR2 or TLR3 agonists (Pam3CSK4, PolyI:C), iNOS express …
Our results showed that purified telocytes expressed TLR2, TLR3 and TLR5. In particular, telocytes expressed high levels of TLR2 …
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