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Table representation of search results timeline featuring number of search results per year.

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1999 1
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268 results
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Page 1
A triacylated lipoprotein from Mycoplasma genitalium activates NF-kappaB through Toll-like receptor 1 (TLR1) and TLR2.
Shimizu T, Kida Y, Kuwano K. Shimizu T, et al. Infect Immun. 2008 Aug;76(8):3672-8. doi: 10.1128/IAI.00257-08. Epub 2008 May 12. Infect Immun. 2008. PMID: 18474641 Free PMC article.
The activation of NF-kappaB by MG149 was inhibited by a dominant negative (DN) construct of TLR1 but not by a DN construct of TLR6. These results indicate that the activation of NF-kappaB by MG149 is dependent on TLR1 and TLR2. A synthetic lipopeptide derived …
The activation of NF-kappaB by MG149 was inhibited by a dominant negative (DN) construct of TLR1 but not by a DN construct of TLR6. T …
TLR2-mediated leukocyte trafficking to the developing brain.
Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C. Mottahedin A, et al. J Leukoc Biol. 2017 Jan;101(1):297-305. doi: 10.1189/jlb.3A1215-568R. Epub 2016 Aug 4. J Leukoc Biol. 2017. PMID: 27493242
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking. Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or T …
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking …
Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells.
Bérubé J, Bourdon C, Yao Y, Rousseau S. Bérubé J, et al. Cell Signal. 2009 Mar;21(3):448-56. doi: 10.1016/j.cellsig.2008.12.001. Epub 2008 Dec 10. Cell Signal. 2009. PMID: 19121387
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capacity to up-regulate Interleukin-8 (IL-8) and Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) in airway epithelial cel …
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capac …
A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.
Shimizu T, Kida Y, Kuwano K. Shimizu T, et al. J Immunol. 2005 Oct 1;175(7):4641-6. doi: 10.4049/jimmunol.175.7.4641. J Immunol. 2005. PMID: 16177110
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicate that the activation of NF-kappaB by F0F1-ATPase is dependent on TLR1, TLR2, and TLR6. ...Thus, a dipalmitoylated lipoprot
The activation of NF-kappaB by the F0F1-ATPase was inhibited by a dominant negative construct of TLR1 and TLR6. These results indicat …
TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects.
Kaur A, Kaushik D, Piplani S, Mehta SK, Petrovsky N, Salunke DB. Kaur A, et al. J Med Chem. 2021 Jan 14;64(1):233-278. doi: 10.1021/acs.jmedchem.0c01627. Epub 2020 Dec 21. J Med Chem. 2021. PMID: 33346636 Review.
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and small heterocyclic molecules. We described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chemistry for th …
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and s …
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.
van Bergenhenegouwen J, Plantinga TS, Joosten LA, Netea MG, Folkerts G, Kraneveld AD, Garssen J, Vos AP. van Bergenhenegouwen J, et al. J Leukoc Biol. 2013 Nov;94(5):885-902. doi: 10.1189/jlb.0113003. Epub 2013 Aug 29. J Leukoc Biol. 2013. PMID: 23990624 Review.
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand speci …
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is uniqu …
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NFkappaB-dependent manner. ...Our results demonstrate …
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis …
Bupivacaine inhibits the TLR4- and TLR2-Myd88/NF-κB pathways in human leukocytes.
Binczak M, Purenne E, Beloeil H, Benhamou D, Mazoit JX. Binczak M, et al. Fundam Clin Pharmacol. 2022 Oct 3. doi: 10.1111/fcp.12836. Online ahead of print. Fundam Clin Pharmacol. 2022. PMID: 36191347
Finally, molecular docking simulations of R(+)- and S(-)-bupivacaine binding to the TLR4-myeloid differentiation protein 2 (MD-2) complex and to the TLR2/TLR1 heterodimer were performed. ...Molecular docking showed that bupivacaine binds to the …
Finally, molecular docking simulations of R(+)- and S(-)-bupivacaine binding to the TLR4-myeloid differentiation protein 2 (MD …
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.
Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH, Ulmer AJ. Farhat K, et al. J Leukoc Biol. 2008 Mar;83(3):692-701. doi: 10.1189/jlb.0807586. Epub 2007 Dec 3. J Leukoc Biol. 2008. PMID: 18056480
This receptor is unique in its ability to form heteromers with TLR1 or TLR6 to mediate intracellular signaling. According to the fatty acid pattern as well as the assembling of the polypeptide tail, LP can signal through TLR2 in a TLR1- or TLR6-dependent mann …
This receptor is unique in its ability to form heteromers with TLR1 or TLR6 to mediate intracellular signaling. According to the fatt …
The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14.
Bas S, Neff L, Vuillet M, Spenato U, Seya T, Matsumoto M, Gabay C. Bas S, et al. J Immunol. 2008 Jan 15;180(2):1158-68. doi: 10.4049/jimmunol.180.2.1158. J Immunol. 2008. PMID: 18178856
Chlamydiae components and signaling pathway(s) responsible for the production of proinflammatory cytokines by human monocytes/macrophages are not clearly identified. ...Proinflammatory activity of rMip was unaffected by heat or proteinase K treatments but was greatly reduc …
Chlamydiae components and signaling pathway(s) responsible for the production of proinflammatory cytokines by human monocytes/macroph …
268 results