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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 2
2002 5
2003 4
2004 3
2005 8
2006 15
2007 16
2008 26
2009 26
2010 23
2011 22
2012 21
2013 16
2014 16
2015 16
2016 10
2017 16
2018 16
2019 11
2020 7
2021 12
2022 9
2023 9
2024 6

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279 results

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Page 1
Macrophage inflammarafts in atherosclerosis.
Li S, Navia-Pelaez JM, Choi SH, Miller YI. Li S, et al. Curr Opin Lipidol. 2023 Oct 1;34(5):189-195. doi: 10.1097/MOL.0000000000000888. Epub 2023 Aug 9. Curr Opin Lipidol. 2023. PMID: 37527160 Review.
RECENT FINDINGS: The term inflammarafts refers to enlarged lipid rafts with increased cholesterol content, hosting components of inflammatory receptor complexes assembled in close proximity, including TLR4-TLR4, TLR2-TLR1 and TLR2-CD36 dimers. Macrophages dec …
RECENT FINDINGS: The term inflammarafts refers to enlarged lipid rafts with increased cholesterol content, hosting components of inflammator …
TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects.
Kaur A, Kaushik D, Piplani S, Mehta SK, Petrovsky N, Salunke DB. Kaur A, et al. J Med Chem. 2021 Jan 14;64(1):233-278. doi: 10.1021/acs.jmedchem.0c01627. Epub 2020 Dec 21. J Med Chem. 2021. PMID: 33346636 Review.
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and small heterocyclic molecules. We described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chemistry for th …
Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and s …
TLR2-mediated leukocyte trafficking to the developing brain.
Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C. Mottahedin A, et al. J Leukoc Biol. 2017 Jan;101(1):297-305. doi: 10.1189/jlb.3A1215-568R. Epub 2016 Aug 4. J Leukoc Biol. 2017. PMID: 27493242
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking. Postnatal day 8 mice were injected intraperitoneally with a TLR1/2 (Pam3CSK4, P3C), TLR2/6 (FSL-1) or TLR4 (LP …
In this study, we tested the hypothesis that activation of peripheral TLR induces inflammation in the brain, including leukocyte trafficking …
Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer.
Liang S, Hosur KB, Lu S, Nawar HF, Weber BR, Tapping RI, Connell TD, Hajishengallis G. Liang S, et al. J Immunol. 2009 Mar 1;182(5):2978-85. doi: 10.4049/jimmunol.0803737. J Immunol. 2009. PMID: 19234193 Free PMC article.
Corresponding point mutants (M69E, A70D, L73E, S74D) were defective in binding TLR2 or TLR1 and could not activate APCs, despite retaining full ganglioside-binding capacity. ...Although the TLR1/LT-IIb-B(5) interface is relatively smaller, the leucine-rich re …
Corresponding point mutants (M69E, A70D, L73E, S74D) were defective in binding TLR2 or TLR1 and could not activate APCs, despi …
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.
van Bergenhenegouwen J, Plantinga TS, Joosten LA, Netea MG, Folkerts G, Kraneveld AD, Garssen J, Vos AP. van Bergenhenegouwen J, et al. J Leukoc Biol. 2013 Nov;94(5):885-902. doi: 10.1189/jlb.0113003. Epub 2013 Aug 29. J Leukoc Biol. 2013. PMID: 23990624 Review.
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand speci …
TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is uniqu …
C4b binding protein negatively regulates TLR1/2 response.
Morita N, Yamai I, Takahashi K, Kusumoto Y, Shibata T, Kobayashi T, Nonaka MI, Ichimonji I, Takagi H, Miyake K, Takamura SA. Morita N, et al. Innate Immun. 2017 Jan;23(1):11-19. doi: 10.1177/1753425916672312. Epub 2016 Oct 28. Innate Immun. 2017. PMID: 27794068 Free article.
TLR2 associates with TLR1 and recognizes microbial lipoproteins. Pam3CSK4, a triacylated lipoprotein, is anchored to the extracellular domain of TLR1 and TLR2 and induces pro-inflammatory signals. ...
TLR2 associates with TLR1 and recognizes microbial lipoproteins. Pam3CSK4, a triacylated lipoprotein, is
Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus.
Pietrocola G, Arciola CR, Rindi S, Di Poto A, Missineo A, Montanaro L, Speziale P. Pietrocola G, et al. Int J Artif Organs. 2011 Sep;34(9):799-810. doi: 10.5301/ijao.5000030. Int J Artif Organs. 2011. PMID: 22094559 Review.
Most mammalian species have 10 to 15 types of TLRs. TLRs are believed to function as homo- or hetero-dimers. TLR2, which plays a crucial role in recognizing PAMPs from Staphylococcus aureus, forms heterodimers with TLR1 or TLR6 and each dimer has a different ligand …
Most mammalian species have 10 to 15 types of TLRs. TLRs are believed to function as homo- or hetero-dimers. TLR2, which plays a cruc …
Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells.
Bérubé J, Bourdon C, Yao Y, Rousseau S. Bérubé J, et al. Cell Signal. 2009 Mar;21(3):448-56. doi: 10.1016/j.cellsig.2008.12.001. Epub 2008 Dec 10. Cell Signal. 2009. PMID: 19121387
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capacity to up-regulate Interleukin-8 (IL-8) and Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) in airway epithelial cel …
In this study, 19 Toll-Like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NOD)1/NOD2 ligands were screened for their capac …
Toll-like receptor cascade and gene polymorphism in host-pathogen interaction in Lyme disease.
Rahman S, Shering M, Ogden NH, Lindsay R, Badawi A. Rahman S, et al. J Inflamm Res. 2016 May 31;9:91-102. doi: 10.2147/JIR.S104790. eCollection 2016. J Inflamm Res. 2016. PMID: 27330321 Free PMC article. Review.
A number of Borrelia outer-surface proteins (eg, OspA and OspB) are recognized by TLRs. Specifically, TLR1 and TLR2 were identified as the receptors most relevant to LD. ...
A number of Borrelia outer-surface proteins (eg, OspA and OspB) are recognized by TLRs. Specifically, TLR1 and TLR2 were ident …
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFkappaB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis by p38 MAPK-dependent activation of Caspase 3 and myeloid differentiation in a NFkappaB-dependent manner. ...Our results demonstrate that …
Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 in MLL-AF9-driven human AML resulted in induction of apoptosis …
279 results