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Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Chen Q, et al. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31. Science. 2016. PMID: 26721680 Free article.
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression p …
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs …
Sperm RNA code programmes the metabolic health of offspring.
Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Nat Rev Endocrinol. 2019. PMID: 31235802 Free PMC article. Review.
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non-coding RNAs) and associated RNA modifications is expanding and has begun to reveal the functional divers …
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25. Nat Cell Biol. 2018. PMID: 29695786 Free PMC article.
How sperm sncRNAs encode paternal information remains unclear, but the mechanism may involve RNA modifications. Here we show that deletion of a mouse tRNA methyltransferase, DNMT2, abolished sperm sncRNA-mediated transmission of high-fat-diet-induced metabolic disor …
How sperm sncRNAs encode paternal information remains unclear, but the mechanism may involve RNA modifications. Here we show that del …
SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs.
Shi J, Ko EA, Sanders KM, Chen Q, Zhou T. Shi J, et al. Among authors: chen q. Genomics Proteomics Bioinformatics. 2018 Apr;16(2):144-151. doi: 10.1016/j.gpb.2018.04.004. Epub 2018 May 3. Genomics Proteomics Bioinformatics. 2018. PMID: 29730207 Free PMC article.
In addition to the previously well-characterized sRNAs such as microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNA (snoRNAs), recent emerging studies have spotlighted on tRNA-derived sRNAs (tsRNAs) and rRNA-derived sRNAs (rsRNAs …
In addition to the previously well-characterized sRNAs such as microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RN
Small RNA Modifications: Integral to Function and Disease.
Zhang X, Cozen AE, Liu Y, Chen Q, Lowe TM. Zhang X, et al. Among authors: chen q. Trends Mol Med. 2016 Dec;22(12):1025-1034. doi: 10.1016/j.molmed.2016.10.009. Epub 2016 Nov 11. Trends Mol Med. 2016. PMID: 27840066 Free PMC article. Review.
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) harbor a diversity of RNA modifications. These findings highlight the importance of RNA modifications in the m …
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived smal …
tsRNAs: The Swiss Army Knife for Translational Regulation.
Shi J, Zhang Y, Zhou T, Chen Q. Shi J, et al. Among authors: chen q. Trends Biochem Sci. 2019 Mar;44(3):185-189. doi: 10.1016/j.tibs.2018.09.007. Epub 2018 Oct 5. Trends Biochem Sci. 2019. PMID: 30297206 Free PMC article.
tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differ
tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent eme
Theaflavin 3,3'-digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes.
Shen Z, Chen Q, Jin T, Wang M, Ying H, Lu J, Wang M, Zhang W, Qiu F, Jin C, Zhao Y, Fu G. Shen Z, et al. Among authors: chen q. J Cell Physiol. 2019 Aug;234(10):17999-18016. doi: 10.1002/jcp.28432. Epub 2019 Mar 7. J Cell Physiol. 2019. PMID: 30847932
The functioning of gap-junctional intercellular communication (GJIC) was measured by a dye transfer assay. Adenosine monophosphate-activated protein kinase (AMPK) activity was determined by western blot. Moreover, AMPK was activated with aminoimidazole-4-carboxamide-1-β-d- …
The functioning of gap-junctional intercellular communication (GJIC) was measured by a dye transfer assay. Adenosine monophosphate-ac …
tsRNAs: new players in mammalian retrotransposon control.
Zhang Y, Shi J, Chen Q. Zhang Y, et al. Among authors: chen q. Cell Res. 2017 Nov;27(11):1307-1308. doi: 10.1038/cr.2017.109. Epub 2017 Aug 25. Cell Res. 2017. PMID: 28840860 Free PMC article.
A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may d …
A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repe …
Small RNA modifications in Alzheimer's disease.
Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q, Feng Earley Y. Zhang X, et al. Among authors: chen q. Neurobiol Dis. 2020 Nov;145:105058. doi: 10.1016/j.nbd.2020.105058. Epub 2020 Aug 21. Neurobiol Dis. 2020. PMID: 32835860 Free article.
Findings We report altered small RNA modifications in AD samples compared with normal controls. The 15-25-nucleotide (nt) RNA fraction of these samples was enriched for microRNAs, whereas the 30-40-nt RNA fraction was enriched for tRNA-derived s …
Findings We report altered small RNA modifications in AD samples compared with normal controls. The 15-25-nucleotide (nt) RNA
A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm.
Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q, Duan E. Peng H, et al. Among authors: chen q. Cell Res. 2012 Nov;22(11):1609-12. doi: 10.1038/cr.2012.141. Epub 2012 Oct 9. Cell Res. 2012. PMID: 23044802 Free PMC article. No abstract available.
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