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Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Chen Q, et al. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977. Epub 2015 Dec 31. Science. 2016. PMID: 26721680 Free article.
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA
In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mai …
Sperm RNA code programmes the metabolic health of offspring.
Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Rev Endocrinol. 2019 Aug;15(8):489-498. doi: 10.1038/s41574-019-0226-2. Epub 2019 Jun 24. Nat Rev Endocrinol. 2019. PMID: 31235802 Free PMC article. Review.
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non-coding RNAs) and associated RNA modifications is expanding and has begun to reveal the functional diversity and inform …
Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and l …
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications.
Chen Q, Yan W, Duan E. Chen Q, et al. Nat Rev Genet. 2016 Dec;17(12):733-743. doi: 10.1038/nrg.2016.106. Epub 2016 Oct 3. Nat Rev Genet. 2016. PMID: 27694809 Free PMC article. Review.
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, an …
The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, R
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Zhang Y, et al. Among authors: chen q. Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25. Nat Cell Biol. 2018. PMID: 29695786 Free PMC article.
Dnmt2 deletion prevented the elevation of RNA modifications (m(5)C, m(2)G) in sperm 30-40 nt RNA fractions that are induced by a high-fat diet. ...Finally, we show that Dnmt2-mediated m(5)C contributes to the secondary structure and biological properties of s …
Dnmt2 deletion prevented the elevation of RNA modifications (m(5)C, m(2)G) in sperm 30-40 nt RNA fractions that are ind …
SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs.
Shi J, Ko EA, Sanders KM, Chen Q, Zhou T. Shi J, et al. Among authors: chen q. Genomics Proteomics Bioinformatics. 2018 Apr;16(2):144-151. doi: 10.1016/j.gpb.2018.04.004. Epub 2018 May 3. Genomics Proteomics Bioinformatics. 2018. PMID: 29730207 Free PMC article.
High-throughput RNA-seq has revolutionized the process of small RNA (sRNA) discovery, leading to a rapid expansion of sRNA categories. ...Moreover, SPORTS1.0 can predict potential RNA modification sites based on nucleotide mismatches within sRNAs. SPOR …
High-throughput RNA-seq has revolutionized the process of small RNA (sRNA) discovery, leading to a rapid expansion of sRNA cat …
Small RNA Modifications: Integral to Function and Disease.
Zhang X, Cozen AE, Liu Y, Chen Q, Lowe TM. Zhang X, et al. Among authors: chen q. Trends Mol Med. 2016 Dec;22(12):1025-1034. doi: 10.1016/j.molmed.2016.10.009. Epub 2016 Nov 11. Trends Mol Med. 2016. PMID: 27840066 Free PMC article. Review.
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) harbor a diversity of RNA modifications. These findings highlight the importance of RNA modifications in the m …
Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs …
Small RNA modifications in Alzheimer's disease.
Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q, Feng Earley Y. Zhang X, et al. Among authors: chen q. Neurobiol Dis. 2020 Nov;145:105058. doi: 10.1016/j.nbd.2020.105058. Epub 2020 Aug 21. Neurobiol Dis. 2020. PMID: 32835860 Free article.
Findings We report altered small RNA modifications in AD samples compared with normal controls. The 15-25-nucleotide (nt) RNA fraction of these samples was enriched for microRNAs, whereas the 30-40-nt RNA fraction was enriched for tRNA-derived small RN …
Findings We report altered small RNA modifications in AD samples compared with normal controls. The 15-25-nucleotide (nt) R
tsRNAs: The Swiss Army Knife for Translational Regulation.
Shi J, Zhang Y, Zhou T, Chen Q. Shi J, et al. Among authors: chen q. Trends Biochem Sci. 2019 Mar;44(3):185-189. doi: 10.1016/j.tibs.2018.09.007. Epub 2018 Oct 5. Trends Biochem Sci. 2019. PMID: 30297206 Free PMC article.
Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis....
Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and struc …
The expanding repertoire of hereditary information carriers.
Zhang Y, Chen Q. Zhang Y, et al. Among authors: chen q. Development. 2019 Mar 15;146(6):dev170902. doi: 10.1242/dev.170902. Development. 2019. PMID: 30877124 Free PMC article.
Epigenetic information in gametes: Gaming from before fertilization: Comment on "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al.
Shi J, Zhang X, Liu Y, Chen Q. Shi J, et al. Among authors: chen q. Phys Life Rev. 2017 Mar;20:146-149. doi: 10.1016/j.plrev.2017.01.001. Epub 2017 Jan 6. Phys Life Rev. 2017. PMID: 28089374 No abstract available.
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