Lessons from a Single Amino Acid Substitution: Anticancer and Antibacterial Properties of Two Phospholipase A2-Derived Peptides.
Almeida JR, Mendes B, Lancellotti M, Franchi GC Jr, Passos Ó, Ramos MJ, Fernandes PA, Alves C, Vale N, Gomes P, da Silva SL.
Almeida JR, et al.
Curr Issues Mol Biol. 2021 Dec 22;44(1):46-62. doi: 10.3390/cimb44010004.
Curr Issues Mol Biol. 2021.
PMID: 35723383
Free PMC article.
Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA(2) toxins (p-AppK and p-Acl), differing by a leucine/phenylalanine substitution, were synthesized and their bioactivity was evaluated. ...In other words, dissecting and fine-tuning biomembrane remodelin …
Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA(2) toxins (p-AppK and p-Acl), differing by a leucine/phenylala …